Detalhe da pesquisa
1.
Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity.
J Immunol
; 206(5): 1067-1076, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483346
2.
Epigenetically quantified immune cells in salivary glands of Sjögren's syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology.
Rheumatology (Oxford)
; 59(2): 335-343, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31325310
3.
Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.
Blood
; 126(13): 1527-35, 2015 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224645
4.
CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister.
Br J Clin Pharmacol
; 83(9): 1976-1990, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28295451
5.
Exacerbated experimental arthritis in Wiskott-Aldrich syndrome protein deficiency: modulatory role of regulatory B cells.
Eur J Immunol
; 44(9): 2692-702, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24945741
6.
Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.
Blood
; 121(1): 72-84, 2013 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23160469
7.
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.
Blood
; 119(12): 2819-28, 2012 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22302739
8.
Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.
J Allergy Clin Immunol
; 131(3): 815-24, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23141740
9.
Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.
Blood
; 118(9): 2492-501, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21690559
10.
Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
J Immunol
; 187(6): 3121-32, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21844382
11.
A randomised, double-blind, placebo-controlled study of the LAG-3-depleting monoclonal antibody GSK2831781 in patients with active ulcerative colitis.
Aliment Pharmacol Ther
; 58(3): 283-296, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37323059
12.
Phosphorylation of WASp is a key regulator of activity and stability in vivo.
Proc Natl Acad Sci U S A
; 106(37): 15738-43, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19805221
13.
Randomized Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2831781 in Healthy Japanese and White Participants.
Clin Pharmacol Drug Dev
; 11(11): 1284-1293, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088650
14.
ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases.
Front Immunol
; 13: 1002629, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36439150
15.
Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures.
Cell Immunol
; 272(1): 1-10, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-22030471
16.
Recent advances in the understanding of genetic defects of neutrophil number and function.
Br J Haematol
; 151(4): 312-26, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20813010
17.
Nonintegrating lentivector vaccines stimulate prolonged T-cell and antibody responses and are effective in tumor therapy.
J Virol
; 83(7): 3094-103, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19176629
18.
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis.
Blood
; 112(10): 4158-69, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18687984
19.
Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates.
PLoS One
; 15(4): e0231655, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32325480
20.
Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.
Mol Ther
; 16(5): 836-44, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18388921