Assuntos
Epiderme/fisiopatologia , Interleucinas/farmacologia , Fenômenos Fisiológicos da Pele/efeitos dos fármacos , beta-Ciclodextrinas/farmacologia , Anidrase Carbônica II/genética , Anidrase Carbônica II/metabolismo , Citocinas/metabolismo , Dermatite Atópica/induzido quimicamente , Epiderme/patologia , Proteínas Filagrinas , Expressão Gênica/efeitos dos fármacos , Humanos , Hialuronan Sintases/metabolismo , Ácido Hialurônico/metabolismo , Interleucina-13/farmacologia , Interleucina-17/farmacologia , Interleucina-4/farmacologia , Proteínas de Filamentos Intermediários/genética , Proteínas de Membrana/genética , Proteínas de Membrana/metabolismo , Proteínas do Tecido Nervoso/genética , Linfopoietina do Estroma do TimoRESUMO
Atopic dermatitis is a multifactorial pathology that includes perturbations of gene expression and increased adhesion of Staphylococcus aureus. Fucoidans are seaweed-derived sulfated fucose-rich polysaccharides that are known to be anti-inflammatory and may inhibit adhesion of pathogens. Fucoidan was assessed for effects on gene expression of an in vitro 3D model of atopic dermatitis. It was also assessed for inhibitory effects on the adhesion of bacteria onto 3D reconstructed skin. Fucoidan significantly altered gene expression in the atopic dermatitis model, and there was a trend to reduce periostin levels. Fucoidan significantly inhibited the adhesion of Staphylococcus aureus and Cutibacterium acnes but did not affect the adhesion of Staphylococcus epidermidis. Fucoidan may be a useful topical agent to assist in the management of atopic dermatitis.