Detalhe da pesquisa
1.
Systematic screening identifies ABCG2 as critical factor underlying synergy of kinase inhibitors with transcriptional CDK inhibitors.
Breast Cancer Res
; 25(1): 51, 2023 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37147730
2.
Combined inhibition of EZH2 and ATM is synthetic lethal in BRCA1-deficient breast cancer.
Breast Cancer Res
; 24(1): 41, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35715861
3.
Towards an advanced testing strategy for genotoxicity using image-based 2D and 3D HepG2 DNA damage response fluorescent protein reporters.
Mutagenesis
; 37(2): 130-142, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34448005
4.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Nature
; 521(7553): 541-544, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799992
5.
Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages.
Arch Toxicol
; 95(10): 3285-3302, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34480604
6.
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.
Genes Dev
; 27(1): 39-51, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23271346
7.
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
EMBO J
; 34(3): 410-24, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582120
8.
BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.
J Pathol
; 246(1): 41-53, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29877575
9.
Prophylactic window therapy with the clinical poly(ADP-ribose) polymerase inhibitor olaparib delays BRCA1-deficient mammary tumour formation in mice.
J Pathol
; 241(4): 511-521, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27943283
10.
Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation.
J Med Genet
; 57(8): 509-518, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32152249
11.
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Proc Natl Acad Sci U S A
; 110(21): 8632-7, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23657012
12.
BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres.
EMBO J
; 34(6): 828, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25766694
13.
Mapping Interindividual Variability of Toxicodynamics Using High-Throughput Transcriptomics and Primary Human Hepatocytes from Fifty Donors.
Environ Health Perspect
; 132(3): 37005, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38498338
14.
New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project.
Front Toxicol
; 5: 1220998, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37492623
15.
Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression.
J Pathol
; 224(1): 10-21, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21404276
16.
Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals.
Toxicol In Vitro
; 81: 105348, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35307500
17.
Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds.
Toxicol Sci
; 181(2): 187-198, 2021 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33769548
18.
Integration of temporal single cell cellular stress response activity with logic-ODE modeling reveals activation of ATF4-CHOP axis as a critical predictor of drug-induced liver injury.
Biochem Pharmacol
; 190: 114591, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33957093
19.
A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.
Cancer Res
; 81(24): 6171-6182, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548335
20.
Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays.
Clin Cancer Res
; 26(17): 4559-4568, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32546644