Detalhe da pesquisa
1.
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Bioorg Med Chem Lett
; 29(19): 126610, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31471167
2.
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Bioorg Med Chem Lett
; 29(3): 509-514, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30553738
3.
Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG1-4, IgM and IgE using standard and customized reference pools for sero-epidemiological and vaccine studies.
Malar J
; 17(1): 219, 2018 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29859096
4.
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Bioorg Med Chem Lett
; 28(19): 3168-3173, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30174152
5.
The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum.
Malar J
; 16(1): 314, 2017 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28779755
6.
Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity.
Infect Immun
; 83(6): 2575-82, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870227
7.
Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
Antimicrob Agents Chemother
; 60(3): 1464-75, 2015 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-26711771
8.
Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion.
Nat Chem Biol
; 9(10): 651-6, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23934245
9.
Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.
Eukaryot Cell
; 12(3): 399-410, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23291621
10.
Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.
Proc Natl Acad Sci U S A
; 108(26): 10568-73, 2011 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21670272
11.
Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte.
Mol Cell Proteomics
; 10(5): M110.001636, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20943600
12.
Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection.
Cell Rep
; 42(7): 112681, 2023 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37389992
13.
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate.
Nat Commun
; 13(1): 933, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35177602
14.
Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies.
Front Cell Infect Microbiol
; 12: 901253, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35782147
15.
Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry.
Chem Commun (Camb)
; (4): 480-2, 2008 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18188474
16.
Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.
Biochem J
; 408(2): 173-80, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17714074
17.
Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major.
Biochem J
; 396(2): 277-85, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480339
18.
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
Nat Commun
; 8(1): 430, 2017 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28874661
19.
Workshop report: Malaria vaccine development in Europe--preparing for the future.
Vaccine
; 33(46): 6137-44, 2015 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26431986
20.
The role of cGMP signalling in regulating life cycle progression of Plasmodium.
Microbes Infect
; 14(10): 831-7, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22613210