Detalhe da pesquisa
1.
Investigating CNS distribution of PF-05212377, a P-glycoprotein substrate, by translation of 5-HT6 receptor occupancy from non-human primates to humans.
Biopharm Drug Dispos
; 44(1): 48-59, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36825693
2.
Inhaled PYY(3-36) dry-powder formulation for appetite suppression.
Drug Dev Ind Pharm
; 42(1): 150-156, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26006332
3.
Metabolism distribution and excretion of a matrix metalloproteinase-13 inhibitor, 4-[4-(4-fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic acid hydroxyamide (CP-544439), in rats and dogs: assessment of the metabolic profile of CP-544439 in plasma and urine of humans.
Drug Metab Dispos
; 36(9): 1869-83, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566038
4.
Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.
J Med Chem
; 61(3): 1001-1018, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293004
5.
Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 60(13): 5673-5698, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574706
6.
Preclinical Evaluation of 18F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme.
J Nucl Med
; 57(9): 1448-53, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27199356
7.
Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.
J Med Chem
; 61(8): 3753, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29624389
8.
Nasal-to-CNS drug delivery: where are we now and where are we heading? An industrial perspective.
Ther Deliv
; 3(2): 195-208, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22834197
9.
Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened.
ACS Med Chem Lett
; 3(2): 106-11, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900436
10.
Current advances in delivery of biotherapeutics across the blood-brain barrier.
Curr Drug Discov Technol
; 8(2): 87-101, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21513485