Detalhe da pesquisa
1.
The shieldin complex mediates 53BP1-dependent DNA repair.
Nature
; 560(7716): 117-121, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30022168
2.
Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.
PLoS Genet
; 16(1): e1008550, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31945059
3.
HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair.
Nucleic Acids Res
; 48(5): 2442-2456, 2020 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31960047
4.
A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2 b: Reactive cobalt substances induce oxidative stress in ToxTracker and activate hypoxia target genes.
Regul Toxicol Pharmacol
; 129: 105120, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35038485
5.
The in vitro ToxTracker and Aneugen Clastogen Evaluation extension assay as a tool in the assessment of relative genotoxic potential of e-liquids and their aerosols.
Mutagenesis
; 36(2): 129-142, 2021 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33769537
6.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition.
Nature
; 521(7553): 541-544, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25799992
7.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Br J Cancer
; 117(1): 113-123, 2017 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28535155
8.
Quantitative interpretation of ToxTracker dose-response data for potency comparisons and mode-of-action determination.
Environ Mol Mutagen
; 64(2): 132-143, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36645179
9.
Utility of ToxTracker in animal alternative testing strategy for fragrance materials.
Environ Mol Mutagen
; 64(4): 234-243, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36762970
10.
TubulinTracker, a Novel In Vitro Reporter Assay to Study Intracellular Microtubule Dynamics, Cell Cycle Progression, and Aneugenicity.
Toxicol Sci
; 186(2): 288-297, 2022 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35094094
11.
Genotoxicity assessment of potentially mutagenic nucleoside analogues using ToxTracker®.
Toxicol Lett
; 362: 50-58, 2022 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35569722
12.
The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay.
Food Chem Toxicol
; 168: 113380, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028061
13.
A novel human stem cell-based biomarker assay for in vitro assessment of developmental toxicity.
Birth Defects Res
; 114(19): 1210-1228, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35289129
14.
Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats.
Toxicol Sci
; 186(1): 83-101, 2022 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34850229
15.
Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response.
Food Chem Toxicol
; 157: 112601, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34626751
16.
Aneugen Versus Clastogen Evaluation and Oxidative Stress-Related Mode-of-Action Assessment of Genotoxic Compounds Using the ToxTracker Reporter Assay.
Toxicol Sci
; 177(1): 202-213, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32617558
17.
On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation.
Cancers (Basel)
; 11(1)2019 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30650591
18.
HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis.
Cell Rep
; 27(13): 3790-3798.e7, 2019 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31242413
19.
Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.
Nat Commun
; 9(1): 1849, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29748565
20.
Directing the use of DDR kinase inhibitors in cancer treatment.
Expert Opin Investig Drugs
; 26(12): 1341-1355, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28984489