Melanoma - investigation and primary treatment. / Melanom ­ utredning og primærbehandling.

Melanoma is a relatively common diagnosis, both in the primary and specialist health service. Ongoing research and new evidence base means that the recommendations for investigation and treatment are continually changing. This can lead to uncertainty among doctors who do not treat this patient group regularly. In this clinical review we give a summary of the latest recommendations, primarily aimed at general practitioners, dermatologists and doctors in local hospitals.

Merkel cell carcinoma. / Merkelcellekarsinom.

Merkel cell carcinoma is an uncommon but aggressive tumour with a high metastatic potential. A rapidly growing, non-tender cutaneous tumour on sun-exposed areas of the body in older patients should raise suspicion of the condition. It may be necessary to combine the patient history with clinical, radiological and pathological findings in order to make the correct diagnosis. Excision with a 1-2 cm margin, direct closure and simultaneous sentinel-node biopsy should be performed without delay. Adjuvant radiation therapy of the tumour site may be relevant. After the diagnosis is made, assessment and treatment should take place in hospitals with special experience of the condition.

Hemophagocytic lymphohistiocytosis in leprosy.

A patient from Southeast Asia was diagnosed with systemic lupus erythematosus. One year later, she experienced exacerbation of skin lesions and was diagnosed with erythema nodosum leprosum. Upon treatment, the patient developed hemophagocytic lymphohistiocytosis with multi-organ failure and died from invasive fungal infection. Hemophagocytic lymphohistiocytosis has to our knowledge, not previously been reported in leprosy.

[Mohs surgery in basal cell carcinoma on the face]. / Mohs' kirurgi ved basalcellekarsinom i ansiktet.

BACKGROUND: Basal cell carcinoma may have a locally aggressive growth pattern. This type of cancer is often located on the face and is difficult to limit clinically. Normal excision and tumour destructive treatment often lead to recurrence of the tumour. Mohs surgery is a radical technique for removing this type of lesion. MATERIAL AND METHOD: This review article is based on articles identified by searching in PubMed with the search words "Mohs surgery" and "basal cell carcinoma", as well as personal experience. RESULTS: 10-15 % of all basal cell carcinomas have an aggressive growth pattern with sub clinical ramifications. Mohs surgery involves use of peroperative histological assessment of horizontal frozen sections, meaning that 100 % of the resection surface can be assessed. The objective is to reduce the risk of recurrence. Since the method saves tissue, simpler reconstruction can often be chosen. Mohs surgery is resource-demanding, but with the lower risk of recurrence, the method can be cost-effective when used for the correct indications. INTERPRETATION: Mohs surgery should be considered in basal cell carcinoma with an aggressive growth pattern on the face.

[Of what significance are diseases, intoxication and suicide in fatal traffic accidents?]. / Hvilken betydning har sykdom, ruspåvirkning og selvmord ved dødsfall blant bilførere?

BACKGROUND: A large proportion of fatal car accidents cannot be explained by traffic environment, technical defects or risk-taking behaviour. Driver impairment from disease, alcohol, drugs or suicidal impulses may be involved. MATERIAL AND METHOD: Autopsy protocols from 167 car drivers involved in traffic accidents in Southeast Norway 1994-99 were reviewed retrospectively. RESULTS: In 89 of 135 deaths caused by trauma, there were no apparent explanations for the accident prior to autopsy. No differences were found with regard to signs of disease between drivers involved in unexplained and explained accidents. Drivers dead from trauma compared to drivers dead from natural causes had less often ischemic heart disease (p < 0.01). Blood alcohol level was above the statutory limit in 20% of drivers in both unexplained and explained accidents, and drugs were found in the blood in 27% of such cases. Only 13% of drivers in explained accidents collided with large motor vehicles, compared to 44% of the unexplained accidents. INTERPRETATION: Drivers with fatal injuries sustained in unexplained accidents seldom show signs of cardiac disease that could have contributed to the accident. It seems that such unexplained accidents are more often due to driving under the influence of alcohol or drugs, or to possible suicidal impulses.

Genital ulcers as initial manifestation of Epstein-Barr virus infection: two new cases and a review of the literature.

Genital ulceration is an uncommon manifestation of primary Epstein-Barr virus (EBV) infection. We present here two cases of genital ulcers probably caused by EBV. The first case is a 12-year-old girl with a genital ulcer appearing before specific EBV serology could identify a primary infection. However, serology was positive 13 days after the ulcer appeared. Polymerase chain reaction for EBV was positive in the biopsy from the ulcer as well. The second case is an 18-year-old female in whom the specific EBV serology was positive 8 days after appearance of the ulcer. The ulcers in both cases healed after 21 days. We reviewed the literature and a total of 26 cases of EBV-associated genital ulcers in females are now published. Median age of the 26 cases is 14.5 years of whom only 6 reports previous sexual contact. Mean healing time for the ulcers is 18 days. Our two cases correspond well with clinical reports of 24 EBV-associated genital ulcers in the literature.