Detalhe da pesquisa
1.
Phase 3 randomized trial of mavorixafor, CXCR4 antagonist, in WHIM syndrome.
Blood
; 2024 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38643510
2.
Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.
J Am Chem Soc
; 133(41): 16477-85, 2011 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21942640
3.
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.
Biochem Pharmacol
; 70(5): 752-61, 2005 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16011832
4.
The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.
AIDS Res Hum Retroviruses
; 19(12): 1135-9, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14709250
5.
The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.
Biochem Pharmacol
; 83(4): 472-9, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22146583
6.
HIV-1 entry inhibition by small-molecule CCR5 antagonists: a combined molecular modeling and mutant study using a high-throughput assay.
Virology
; 413(2): 231-43, 2011 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21388649
7.
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replication.
J Med Chem
; 53(3): 1250-60, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043638
8.
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
J Med Chem
; 53(8): 3376-88, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20297846
9.
Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4.
Biochem Pharmacol
; 78(8): 993-1000, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19540208
10.
Spontaneous enzymatically mediated dynamic kinetic resolution of 8-amino-5,6,7,8-tetrahydroquinoline.
J Org Chem
; 72(2): 669-71, 2007 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17221995
11.
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor.
J Virol
; 81(7): 3632-9, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17251291
12.
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor.
J Biol Chem
; 282(37): 27354-27365, 2007 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17599916
13.
Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro.
Br J Haematol
; 134(3): 326-9, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16787495
14.
AMD3465, a novel CXCR4 receptor antagonist, abrogates schistosomal antigen-elicited (type-2) pulmonary granuloma formation.
Am J Pathol
; 169(2): 424-32, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16877345
15.
Palladium(0)-catalyzed coupling of organozinc iodide reagents with bromopyridines: synthesis of selectively protected pyridine-containing azamacrocycles.
J Org Chem
; 67(4): 1407-10, 2002 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11846698
16.
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.
Am J Pathol
; 160(4): 1353-60, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11943720
17.
Concise preparation of amino-5,6,7,8-tetrahydroquinolines and amino-5,6,7,8-tetrahydroisoquinolines via catalytic hydrogenation of acetamidoquinolines and acetamidoisoquinolines.
J Org Chem
; 67(22): 7890-3, 2002 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12398523
18.
Enzymatic resolution of bicyclic 1-heteroarylamines using Candida antarctica lipase B.
J Org Chem
; 68(9): 3546-51, 2003 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-12713358
19.
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor.
J Biol Chem
; 279(4): 3033-41, 2004 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-14585837
20.
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor.
Biochemistry
; 42(3): 710-7, 2003 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12534283