Detalhe da pesquisa
1.
Combination Therapy with Gallium Protoporphyrin and Gallium Nitrate Exhibits Enhanced Antimicrobial Activity In Vitro and In Vivo against Methicillin-Resistant Staphylococcus aureus.
Mol Pharm
; 20(8): 4058-4070, 2023 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37471668
2.
Synthesis and in vitro analysis of novel gallium tetrakis(4-methoxyphenyl)porphyrin and its long-acting nanoparticle as a potent antimycobacterial agent.
Bioorg Med Chem Lett
; 62: 128645, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219822
3.
Iron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumannii.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30782994
4.
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice.
Mol Pharm
; 15(3): 1215-1225, 2018 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29421865
5.
Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells.
Infect Immun
; 85(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28630072
6.
Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167548
7.
Passive transfer of interferon-γ over-expressing macrophages enhances resistance of SCID mice to Mycobacterium tuberculosis infection.
Cytokine
; 95: 70-79, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28237876
8.
Gallium Compounds Exhibit Potential as New Therapeutic Agents against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 59(8): 4826-34, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26033732
9.
Gallium nitrate is efficacious in murine models of tuberculosis and inhibits key bacterial Fe-dependent enzymes.
Antimicrob Agents Chemother
; 57(12): 6074-80, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24060870
10.
Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells.
Microb Pathog
; 65: 21-8, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24067451
11.
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens.
ACS Infect Dis
; 9(4): 716-738, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995299
12.
Inactivation of the potent Pseudomonas aeruginosa cytotoxin pyocyanin by airway peroxidases and nitrite.
Am J Physiol Lung Cell Mol Physiol
; 302(10): L1044-56, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22345574
13.
Combining Gallium Protoporphyrin and Gallium Nitrate Enhances In Vitro and In Vivo Efficacy against Pseudomonas aeruginosa: Role of Inhibition of Bacterial Antioxidant Enzymes and Resultant Increase in Cytotoxic Reactive Oxygen Species.
ACS Infect Dis
; 8(10): 2096-2105, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049087
14.
Airway peroxidases catalyze nitration of the {beta}2-agonist salbutamol and decrease its pharmacological activity.
J Pharmacol Exp Ther
; 336(2): 440-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20974700
15.
Airway delivery of silica increases susceptibility to mycobacterial infection in mice: potential role of repopulating macrophages.
J Immunol
; 182(11): 7102-9, 2009 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19454707
16.
Oxidation of thiols and modification of redox-sensitive signaling in human lung epithelial cells exposed to Pseudomonas pyocyanin.
J Toxicol Environ Health A
; 74(1): 43-51, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21120747
17.
Nanoparticulate ß-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium.
ACS Infect Dis
; 7(8): 2299-2309, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314150
18.
Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma.
Cancers (Basel)
; 13(9)2021 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34066839
19.
Gallium disrupts iron uptake by intracellular and extracellular Francisella strains and exhibits therapeutic efficacy in a murine pulmonary infection model.
Antimicrob Agents Chemother
; 54(1): 244-53, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19917753
20.
The transition metal gallium disrupts Pseudomonas aeruginosa iron metabolism and has antimicrobial and antibiofilm activity.
J Clin Invest
; 117(4): 877-88, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17364024