Detalhe da pesquisa
1.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
PLoS Biol
; 22(4): e3002259, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683873
2.
Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli.
PLoS Pathog
; 19(7): e1011437, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37450466
3.
The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence.
Proc Natl Acad Sci U S A
; 119(11): e2122161119, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35271388
4.
Mucosal delivery of ESX-1-expressing BCG strains provides superior immunity against tuberculosis in murine type 2 diabetes.
Proc Natl Acad Sci U S A
; 117(34): 20848-20859, 2020 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32778586
5.
Breaching the phagosome, the case of the tuberculosis agent.
Cell Microbiol
; 23(7): e13344, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33860624
6.
Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages.
PLoS Pathog
; 15(11): e1008069, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31703112
7.
Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.
Proc Natl Acad Sci U S A
; 115(5): E1002-E1011, 2018 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343644
8.
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
PLoS Pathog
; 14(6): e1007139, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29912964
9.
Mycobacterial ESX-1 secretion system mediates host cell lysis through bacterium contact-dependent gross membrane disruptions.
Proc Natl Acad Sci U S A
; 114(6): 1371-1376, 2017 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28119503
10.
Horizontal acquisition of a hypoxia-responsive molybdenum cofactor biosynthesis pathway contributed to Mycobacterium tuberculosis pathoadaptation.
PLoS Pathog
; 13(11): e1006752, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-29176894
11.
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
PLoS Pathog
; 13(5): e1006399, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-28545104
12.
Key experimental evidence of chromosomal DNA transfer among selected tuberculosis-causing mycobacteria.
Proc Natl Acad Sci U S A
; 113(35): 9876-81, 2016 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27528665
13.
Release of mycobacterial antigens.
Immunol Rev
; 264(1): 25-45, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25703550
14.
Discovery of the type VII ESX-1 secretion needle?
Mol Microbiol
; 103(1): 7-12, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27859892
15.
CD4+ T Cells Recognizing PE/PPE Antigens Directly or via Cross Reactivity Are Protective against Pulmonary Mycobacterium tuberculosis Infection.
PLoS Pathog
; 12(7): e1005770, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27467705
16.
Type VII Secretion Systems in Gram-Positive Bacteria.
Curr Top Microbiol Immunol
; 404: 235-265, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-26847354
17.
ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.
Cell Microbiol
; 19(7)2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28095608
18.
Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members.
Mol Microbiol
; 99(5): 866-83, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26585558
19.
The changes in mycolic acid structures caused by hadC mutation have a dramatic effect on the virulence of Mycobacterium tuberculosis.
Mol Microbiol
; 99(4): 794-807, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26538472
20.
A new piperidinol derivative targeting mycolic acid transport in Mycobacterium abscessus.
Mol Microbiol
; 101(3): 515-29, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27121350