Detalhe da pesquisa
1.
Discovery and development of ASK1 inhibitors.
Prog Med Chem
; 59: 101-179, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32362327
2.
Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
J Immunol
; 191(7): 3568-77, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24006460
3.
Discovery of GLPG3667, a Selective ATP Competitive Tyrosine Kinase 2 Inhibitor for the Treatment of Autoimmune Diseases.
J Med Chem
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38805213
4.
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
J Med Chem
; 67(7): 5233-5258, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38552030
5.
Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312.
J Med Chem
; 67(1): 380-401, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38147525
6.
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Sci Transl Med
; 15(683): eabj3289, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36791209
7.
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
Bioorg Med Chem Lett
; 22(6): 2266-70, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22342143
8.
Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 64(9): 6037-6058, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33939425
9.
Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.
J Med Chem
; 64(19): 14557-14586, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34581584
10.
The Medium-Chain Fatty Acid Receptor GPR84 Mediates Myeloid Cell Infiltration Promoting Steatohepatitis and Fibrosis.
J Clin Med
; 9(4)2020 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32316235
11.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902984
12.
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
J Invest Dermatol
; 138(7): 1555-1563, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474945
13.
Arrayed adenoviral expression libraries for functional screening.
Nat Biotechnol
; 20(11): 1154-7, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12355097
14.
Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 60(9): 3580-3590, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28414242
15.
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
J Med Chem
; 60(17): 7371-7392, 2017 09 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28731719
16.
Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
J Med Chem
; 57(22): 9323-42, 2014 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25369270
17.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380412
18.
Correction to Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2- a]pyridine Series of Autotaxin Inhibitors.
J Med Chem
; 61(9): 4270, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29672037
19.
A multiparameter approach to monitor disease activity in collagen-induced arthritis.
Arthritis Res Ther
; 12(4): R160, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20731827
20.
The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation.
Arthritis Rheum
; 60(5): 1272-81, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19404936