Formulation of Suppositories of Alum Produced from Bauxite Waste in Ghana for the Treatment of Hemorrhoid.

The study sought to formulate and evaluate suppositories using a locally produced brand of alum (Aw) obtained from bauxite waste generated at Awaso bauxite mine in the Western-North region of Ghana, for use in the treatment of hemorrhoids. The suppositories were formulated using shea butter modified, respectively, with amounts of beeswax and theobroma oil. In another development, theobroma oil was modified with different concentrations of beeswax. Drug-base interactions were investigated using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy. The suppositories were prepared using the hot melt and trituration methods. Quality control checks were carried out on the formulations. The evaluated parameters included physical characteristics (texture, presence or absence of entrapped air, and contraction holes), weight uniformity, disintegration time, drug content, and in vitro release profile of the alum from the formulated suppositories. An in vivo analysis was carried out on the most suitable formulation to ascertain its efficacy on inflamed tissues using croton oil-induced rectal inflammation in a rat model. A critical examination of the ATR-FTIR spectra revealed no drug-base interactions. The suppository formulations passed all Pharmacopoeia stated tests. The in vivo study revealed the use of suppositories ameliorated the croton oil-induced hemorrhoid in the rectoanal region of the rats.

Assessment of Typha capensis for the remediation of soil contaminated with As, Hg, Cd and Pb.

The use of macrophytes has been identified as one of the eco-friendly means of remediating soils contaminated with heavy metal(loid)s. This study sought to ascertain the synergistic influences of Hg, As, Cd and Pb on the uptake capacity of Typha capensis in remediating soils contaminated with these pollutants. Uptake of Hg, As, Cd and Pb by this aquatic plant species in metal(loid)-contaminated water and soil was studied in batch culture experiment. The plants were irrigated with standard heavy metal(loid)-simulated solutions. After 20, 40 and 60 days, plant samples were subjected to heavy metal(loid) analysis by a Unicam 969 atomic absorption spectrometer (AAS). The macrophytes were able to remediate all the four selected heavy metal(loid)s when they either existed as individual or when all the four were in the solution; however, the level of uptake by the plant was inhibited when either two of the heavy metals existed in the solution. Typha capensis performs better in the absorption of mercury, arsenic, cadmium and lead in large quantities from polluted water and soil.

Defluoridation of groundwater using aluminum-coated bauxite: Optimization of synthesis process conditions and equilibrium study.

There is no known effective treatment for fluoride-related health disorders, hence prevention through water defluoridation is necessary. This study explored the possibility of modifying the physico-chemical properties of bauxite, a locally available material in many countries including Ghana, by thermal treatment and an aluminum coating, for water defluoridation. The study mainly focused on investigating the effects of varying synthesis process conditions on the defluoridation efficiency of Granular Aluminum Coated Bauxite (GACB). GACB performed better than raw bauxite (RB) and was able to reduce fluoride concentration in groundwater from 5 ± 0.2 mg/L to ≤ 1.5 mg/L, World Health Organization (WHO) guideline. Based on nonlinear Chi-square (χ(2)) analysis, the best-fitting isotherm model for the fluoride-GACB system was in the order: Freundlich > Redlich-Perterson ≈ Langmuir > Temkin. The fluoride adsorption capacity of GACB (qmax = 12.29 mg/g) based on the Langmuir model was found to be either comparable or higher than the capacities of some reported fluoride adsorbents. Aluminum (Al) coating procedures optimized in this study could therefore be a useful approach for synthesizing an effective fluoride adsorbent using bauxite, a locally available material. Kinetic and isotherm analysis, thermodynamic calculations, as well as FTIR and Raman analysis suggested the mechanism of fluoride adsorption onto GACB was complex and involved both physical adsorption and chemisorption processes.

Quantitative assessment of exposure to fecal contamination in urban environment across nine cities in low-income and lower-middle-income countries and a city in the United States.

BACKGROUND: During 2014 to 2019, the SaniPath Exposure Assessment Tool, a standardized set of methods to evaluate risk of exposure to fecal contamination in the urban environment through multiple exposure pathways, was deployed in 45 neighborhoods in ten cities, including Accra and Kumasi, Ghana; Vellore, India; Maputo, Mozambique; Siem Reap, Cambodia; Atlanta, United States; Dhaka, Bangladesh; Lusaka, Zambia; Kampala, Uganda; Dakar, Senegal. OBJECTIVE: Assess and compare risk of exposure to fecal contamination via multiple pathways in ten cities. METHODS: In total, 4053 environmental samples, 4586 household surveys, 128 community surveys, and 124 school surveys were collected. E. coli concentrations were measured in environmental samples as an indicator of fecal contamination magnitude. Bayesian methods were used to estimate the distributions of fecal contamination concentration and contact frequency. Exposure to fecal contamination was estimated by the Monte Carlo method. The contamination levels of ten environmental compartments, frequency of contact with those compartments for adults and children, and estimated exposure to fecal contamination through any of the surveyed environmental pathways were compared across cities and neighborhoods. RESULTS: Distribution of fecal contamination in the environment and human contact behavior varied by city. Universally, food pathways were the most common dominant route of exposure to fecal contamination across cities in low-income and lower-middle-income countries. Risks of fecal exposure via water pathways, such as open drains, flood water, and municipal drinking water, were site-specific and often limited to smaller geographic areas (i.e., neighborhoods) instead of larger areas (i.e., cities). CONCLUSIONS: Knowledge of the relative contribution to fecal exposure from multiple pathways, and the environmental contamination level and frequency of contact for those "dominant pathways" could provide guidance for Water, Sanitation, and Hygiene (WASH) programming and investments and enable local governments and municipalities to improve intervention strategies to reduce the risk of exposure to fecal contamination.

Clean vehicles, polluted waters: empirical estimates of water consumption and pollution loads of the carwash industry.

Carwash stations use large volumes of water and release harmful chemicals into the environment through their operations. While a significant body of literature has focused on exploring water use in the carwash industry, none has provided comprehensive information on both the pollution loads of the wastewater emanating from this industry and water consumption. Understanding how much water is used and the pollution loads of wastewater from this industry is useful to ensure adoption of water conservation measures and design wastewater recycling systems given the dwindling freshwater resources globally. This study estimated the freshwater quantities used to wash different vehicle types and the pollution loads of the resulting wastewater in the Kumasi Metropolis. Seven proxy carwash stations were purposively selected and monitored to estimate the water used to wash six different categories of vehicles. Composite wastewater samples from three carwash stations were analysed for concentrations of different contaminants which were used to compute pollution loads. Using R software, one-way ANOVA with Tukey's (HSD) post-hoc testing and 2-sample t-test at 95% confidence interval were employed to test statistical differences. After an 8-week monitoring campaign involving 3,667 vehicles, the study showed that average water used for each vehicle type were in the order: Motorbike - 97L (95% CI: 90-103L); Salon car - 158L (95% CI: 154-161L); SUV - 197L (95% CI:191-203L); Buses/Coaches - 370L (95%CI:351-381L); Articulated truck 1,139L (95% CI:916-1,363L); Graders/Loaders - 1405L (95% CI:327-2,483L). Overall, the carwash industry in the Metropolis uses about 1000m3 of freshwater daily and discharges the resulting wastewater into waterways untreated. The wastewater has a low Biodegradability Index (0.3-0.4) and is characterized by a mildly alkali pH (7.6-8.6) with high levels of Sulphates (40.8-69.8 mg/L), COD (990-1413 mg/L), TSS (1260-3417 mg/L) and E. coli (2.3-4.7 × 103 CFU/100mL). Pollution loads of BOD and COD were up to 2tons/year and 6tons/year respectively. Stipulated effluent discharge guideline values were mostly exceeded - in some cases by up to 68 times. To avert the unbridled wastage of freshwater, the study recommends enforcement of wastewater recycling for all carwash stations and promulgation of a tax system that rewards stations that recycle wastewater and surchages those wasting freshwater.

Treating waste with waste: the potential of synthesized alum from bauxite waste for treating car wash wastewater for reuse.

This study assessed the contaminant removal potential of a low-cost alum synthesized from bauxite slime waste compared to industrial grade alum [Al2(SO4)3.18H2O] in treating car wash wastewater using standard jar tests. The synthesized alum was subsequently applied as a coagulant to test the short-term performance of a bench scale flocculation-flotation system for treating car wash wastewater. Coagulant dosages and mixing intensities were optimized for both coagulants and differences were analyzed with R using two-way ANOVA with Tukey's (HSD) post hoc testing. Per the jar tests, percentage removal of up to 99%, 34%, and 75% of turbidity, anionic surfactants (AS), and COD, respectively, was achieved with 90 mg/L of the synthesized alum compared to 100%, 37%, and 74% for industrial grade alum. Contaminant removal efficiencies of both coagulants were comparable (p > 0.05). However, coagulant dosage strongly influenced the removal of turbidity, AS, and COD (p < 0.05) while mixing intensity influenced all but COD. The bench-scale flocculation-flotation system completely removed turbidity (100%) and reduced AS and COD by up to 92% and 99% respectively. The results of this study demonstrate the potential of alum synthesized from bauxite slime waste as a cheaper alternative for industrial grade alum in wastewater recycling for the car wash industry.