Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering.

Galvagnion, Céline; Barclay, Abigail; Makasewicz, Katarzyna; Marlet, Frederik Ravnkilde; Moulin, Martine; Devos, Juliette M; Linse, Sara; Martel, Anne; Porcar, Lionel; Sparr, Emma; Pedersen, Martin Cramer; Roosen-Runge, Felix; Arleth, Lise; Buell, Alexander K.

Phys Chem Chem Phys ; 26(14): 10998-11013, 2024 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-38526443

2.

Emerging experimental methods to study the thermodynamics of biomolecular condensate formation.

Ray, Soumik; Buell, Alexander K.

J Chem Phys ; 160(9)2024 Mar 07.

Artigo em Inglês | MEDLINE | ID: mdl-38445729

3.

Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.

Sternke-Hoffmann, Rebecca; Pauly, Thomas; Norrild, Rasmus K; Hansen, Jan; Tucholski, Florian; Høie, Magnus Haraldson; Marcatili, Paolo; Dupré, Mathieu; Duchateau, Magalie; Rey, Martial; Malosse, Christian; Metzger, Sabine; Boquoi, Amelie; Platten, Florian; Egelhaaf, Stefan U; Chamot-Rooke, Julia; Fenk, Roland; Nagel-Steger, Luitgard; Haas, Rainer; Buell, Alexander K.

BMC Biol ; 21(1): 21, 2023 02 03.

Artigo em Inglês | MEDLINE | ID: mdl-36737754

4.

Taylor Dispersion-Induced Phase Separation for the Efficient Characterisation of Protein Condensate Formation.

Norrild, Rasmus K; Mason, Thomas O; Boyens-Thiele, Lars; Ray, Soumik; Mortensen, Joachim B; Fritsch, Anatol W; Iglesias-Artola, Juan M; Klausen, Louise K; Stender, Emil G P; Jensen, Henrik; Buell, Alexander K.

Angew Chem Int Ed Engl ; : e202404018, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38593269

5.

Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.

Farzadfard, Azad; König, Annekatrin; Petersen, Steen Vang; Nielsen, Janni; Vasili, Eftychia; Dominguez-Meijide, Antonio; Buell, Alexander K; Outeiro, Tiago Fleming; Otzen, Daniel E.

J Biol Chem ; 298(5): 101848, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35314196

6.

Pyroglutamate-modified amyloid ß(3-42) monomer has more ß-sheet content than the amyloid ß(1-42) monomer.

Nath, Soumav; Buell, Alexander K; Barz, Bogdan.

Phys Chem Chem Phys ; 25(24): 16483-16491, 2023 Jun 21.

Artigo em Inglês | MEDLINE | ID: mdl-37306611

7.

De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma.

Dupré, Mathieu; Duchateau, Magalie; Sternke-Hoffmann, Rebecca; Boquoi, Amelie; Malosse, Christian; Fenk, Roland; Haas, Rainer; Buell, Alexander K; Rey, Martial; Chamot-Rooke, Julia.

Anal Chem ; 93(30): 10627-10634, 2021 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-34292722

8.

The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth.

van Gils, Juami Hermine Mariama; van Dijk, Erik; Peduzzo, Alessia; Hofmann, Alexander; Vettore, Nicola; Schützmann, Marie P; Groth, Georg; Mouhib, Halima; Otzen, Daniel E; Buell, Alexander K; Abeln, Sanne.

PLoS Comput Biol ; 16(5): e1007767, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32365068

9.

Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.

López-Méndez, Blanca; Baron, Bruno; Brautigam, Chad A; Jowitt, Thomas A; Knauer, Stefan H; Uebel, Stephan; Williams, Mark A; Sedivy, Arthur; Abian, Olga; Abreu, Celeste; Adamczyk, Malgorzata; Bal, Wojciech; Berger, Sylvie; Buell, Alexander K; Carolis, Carlo; Daviter, Tina; Fish, Alexander; Garcia-Alai, Maria; Guenther, Christian; Hamacek, Josef; Holková, Jitka; Houser, Josef; Johnson, Chris; Kelly, Sharon; Leech, Andrew; Mas, Caroline; Matulis, Daumantas; McLaughlin, Stephen H; Montserret, Roland; Nasreddine, Rouba; Nehmé, Reine; Nguyen, Quyen; Ortega-Alarcón, David; Perez, Kathryn; Pirc, Katja; Piszczek, Grzegorz; Podobnik, Marjetka; Rodrigo, Natalia; Rokov-Plavec, Jasmina; Schaefer, Susanne; Sharpe, Tim; Southall, June; Staunton, David; Tavares, Pedro; Vanek, Ondrej; Weyand, Michael; Wu, Di.

Eur Biophys J ; 50(3-4): 411-427, 2021 May.

Artigo em Inglês | MEDLINE | ID: mdl-33881594

10.

The growth of amyloid fibrils: rates and mechanisms.

Buell, Alexander K.

Biochem J ; 476(19): 2677-2703, 2019 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-31654060

11.

The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation.

Sternke-Hoffmann, Rebecca; Peduzzo, Alessia; Bolakhrif, Najoua; Haas, Rainer; Buell, Alexander K.

Int J Mol Sci ; 21(6)2020 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-32183378

12.

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar, Ricardo; Meisl, Georg; Buell, Alexander K; Young, Laurence; Kaminski, Clemens F; Knowles, Tuomas P J; Sparr, Emma; Linse, Sara.

Q Rev Biophys ; 50: e6, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-29233218

13.

Thermodynamics of amyloid fibril formation from chemical depolymerization.

Vettore, Nicola; Buell, Alexander K.

Phys Chem Chem Phys ; 21(47): 26184-26194, 2019 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-31755512

14.

The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly.

Mason, Thomas O; Buell, Alexander K.

Adv Exp Med Biol ; 1174: 61-112, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31713197

15.

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.

Flagmeier, Patrick; Meisl, Georg; Vendruscolo, Michele; Knowles, Tuomas P J; Dobson, Christopher M; Buell, Alexander K; Galvagnion, Céline.

Proc Natl Acad Sci U S A ; 113(37): 10328-33, 2016 09 13.

Artigo em Inglês | MEDLINE | ID: mdl-27573854

16.

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.

Galvagnion, Céline; Brown, James W P; Ouberai, Myriam M; Flagmeier, Patrick; Vendruscolo, Michele; Buell, Alexander K; Sparr, Emma; Dobson, Christopher M.

Proc Natl Acad Sci U S A ; 113(26): 7065-70, 2016 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-27298346

17.

Nanoscopic insights into seeding mechanisms and toxicity of α-synuclein species in neurons.

Pinotsi, Dorothea; Michel, Claire H; Buell, Alexander K; Laine, Romain F; Mahou, Pierre; Dobson, Christopher M; Kaminski, Clemens F; Kaminski Schierle, Gabriele S.

Proc Natl Acad Sci U S A ; 113(14): 3815-9, 2016 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-26993805

18.

Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Gang, Hongze; Galvagnion, Céline; Meisl, Georg; Müller, Thomas; Pfammatter, Manuela; Buell, Alexander K; Levin, Aviad; Dobson, Christopher M; Mu, Bozhong; Knowles, Tuomas P J.

Anal Chem ; 90(5): 3284-3290, 2018 03 06.

Artigo em Inglês | MEDLINE | ID: mdl-29313342

19.

Nanobodies raised against monomeric É-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina, Marija; Hong, Liu; Horrocks, Mathew H; Ludtmann, Marthe H; Choi, Minee L; Hughes, Craig D; Ruggeri, Francesco S; Guilliams, Tim; Buell, Alexander K; Lee, Ji-Eun; Gandhi, Sonia; Lee, Steven F; Bryant, Clare E; Vendruscolo, Michele; Knowles, Tuomas P J; Dobson, Christopher M; De Genst, Erwin; Klenerman, David.

BMC Biol ; 15(1): 57, 2017 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-28673288

20.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

Mason, Thomas O; Michaels, Thomas C T; Levin, Aviad; Dobson, Christopher M; Gazit, Ehud; Knowles, Tuomas P J; Buell, Alexander K.

J Am Chem Soc ; 139(45): 16134-16142, 2017 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-28994295

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