Detalhe da pesquisa
1.
Design and Biological Evaluation of Piperazine-Bearing Nitrobenzamide Hypoxia/GDEPT Prodrugs: The Discovery of CP-506.
ACS Med Chem Lett
; 14(11): 1517-1523, 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37974941
2.
Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling.
Front Pharmacol
; 13: 803602, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35211015
3.
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications.
Pharmaceuticals (Basel)
; 15(2)2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35215297
4.
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors.
ACS Pharmacol Transl Sci
; 5(6): 429-439, 2022 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35711815
5.
Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes.
Clin Cancer Res
; 27(5): 1463-1475, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355298
6.
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3.
Pharmaceuticals (Basel)
; 14(12)2021 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34959631
7.
Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506.
Mol Cancer Ther
; 20(12): 2372-2383, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34625504
8.
Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.
J Med Chem
; 63(5): 2229-2239, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525966
9.
Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy.
Biochem Pharmacol
; 116: 176-87, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27453434