Detalhe da pesquisa
1.
Targeting G-CSF to treat autoinflammation.
Nat Immunol
; 24(5): 736-737, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36997672
2.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
3.
Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations.
J Clin Immunol
; 40(7): 987-1000, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32671674
4.
Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.
Int J Mol Sci
; 21(9)2020 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32370101
5.
Dysfunction of phospholipase Cγ in immune disorders and cancer.
Trends Biochem Sci
; 39(12): 603-11, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25456276
6.
Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.
Biophys J
; 115(1): 31-45, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29972810
7.
Global Profiling of Huntingtin-associated protein E (HYPE)-Mediated AMPylation through a Chemical Proteomic Approach.
Mol Cell Proteomics
; 15(2): 715-25, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26604261
8.
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
Mol Cell
; 34(2): 223-33, 2009 Apr 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19394299
9.
PLC regulation: emerging pictures for molecular mechanisms.
Trends Biochem Sci
; 36(2): 88-96, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20870410
10.
A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
Am J Hum Genet
; 91(4): 713-20, 2012 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23000145
11.
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
N Engl J Med
; 366(4): 330-8, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22236196
12.
Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.
Nat Genet
; 38(12): 1397-405, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17086182
13.
A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.
Biochim Biophys Acta Mol Basis Dis
; 1869(2): 166601, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36442790
14.
Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.
Sci Adv
; 8(25): eabp9688, 2022 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35749497
15.
TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation.
Mol Neurodegener
; 16(1): 22, 2021 04 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823896
16.
Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
J Biol Chem
; 284(34): 23083-93, 2009 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19531496
17.
Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
EBioMedicine
; 51: 102607, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31918402
18.
In vitro reconstitution of activation of PLCepsilon by Ras and Rho GTPases.
Methods Mol Biol
; 462: 379-89, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19160682
19.
Multiplexed FRET to image multiple signaling events in live cells.
Biophys J
; 95(10): L69-71, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757561
20.
NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.
Biomol NMR Assign
; 12(2): 231-235, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29582384