Detalhe da pesquisa
1.
Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model.
J Inherit Metab Dis
; 45(3): 470-480, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34988999
2.
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis.
Metabolism
; 154: 155830, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38428673
3.
Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver.
iScience
; 24(11): 103233, 2021 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34755088
4.
Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy.
Breast Cancer Res Treat
; 124(1): 1-11, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20803067
5.
Biomarkers in the pharmaceutical industry.
Clin Chem
; 61(4): 579-83, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25376580
6.
Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities.
Nat Rev Neurol
; 16(7): 381-400, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32541893
7.
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
J Pharmacol Exp Ther
; 331(2): 598-608, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19671883
8.
Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.
Mol Cell Endocrinol
; 302(1): 26-32, 2009 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356623
9.
Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers.
J Clin Psychopharmacol
; 29(1): 39-43, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19142106
10.
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.
J Clin Pharmacol
; 49(6): 643-9, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19398602
11.
Use of ex vivo systems for biomarker discovery.
Curr Opin Pharmacol
; 8(5): 647-53, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771752
12.
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells.
J Transl Med
; 6: 59, 2008 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18925943
13.
An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects.
Drug Metab Dispos
; 36(12): 2484-91, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809731
14.
Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.
Mol Neurodegener
; 13(1): 25, 2018 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29783994
15.
Molecular classification of Crohn's disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells.
J Mol Diagn
; 8(1): 51-61, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16436634
16.
Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies.
Pharmacogenomics
; 7(2): 187-202, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16515398
17.
Transcriptional profiles in peripheral blood mononuclear cells prognostic of clinical outcomes in patients with advanced renal cell carcinoma.
Clin Cancer Res
; 11(3): 1181-9, 2005 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15709187
18.
Clinical pharmacogenomics and transcriptional profiling in early phase oncology clinical trials.
Curr Mol Med
; 5(1): 83-102, 2005 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-15720272
19.
Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma.
Cancer Res
; 63(18): 6069-75, 2003 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14522937
20.
Population pharmacokinetics of CCI-779: correlations to safety and pharmacogenomic responses in patients with advanced renal cancer.
Clin Pharmacol Ther
; 77(1): 76-89, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15637533