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1.
An Acad Bras Cienc ; 94(2): e20200561, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35703689

RESUMO

Regular exercise is beneficial to health. This study evaluated the effects of moderate and intense physical exercise modalities on intradermal infection by Staphylococcus aureus in a murine model. Mice that practiced moderate exercise had lower bacterial load on lymph nodes and less inflammatory infiltrate in dermis. They presented greater weight, however, less amount of epididymal fat: the weight was increased while they had fat diminished. A positive correlation was observed between lipid content and bacterial load in mice trained at moderate intensity. Animals that were under high intensity exercises presented superior bacterial load on the lymph nodes, increased neutrophil count and circulating lymphocytes, and had leukocyte recruitment to the dermis augmented, when compared to the ones in moderate exercise. These findings suggest that moderate physical activity modulates the immune response in dermal infection caused by S. aureus in a murine model.


Assuntos
Infecções Estafilocócicas , Staphylococcus aureus , Animais , Carga Bacteriana , Modelos Animais de Doenças , Camundongos , Projetos Piloto
2.
Exp Gerontol ; 127: 110734, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31518664

RESUMO

In women, aging is evidenced by physiological hormonal alterations that trigger changes in body composition, emergence of chronic low-grade inflammation, which is an important pre-disposition to the development of chronic diseases such as Systemic Arterial Hypertension (SAH) and Type 2 Diabetes Mellitus (T2DM). Although it is a strong pro-inflammatory nature disorder, little is known about how body composition interferes with inflammatory markers in diabetic and hypertensive elderly women. Therefore, this study's objective was to evaluate the inflammation in diabetic and hypertensive elderly women, and their association with fat mass. It comprised the evaluation of 144 women aged between 60 and 80 years old, diagnosed with SAH and T2DM, assisted by Family Health Units in Vitória da Conquista, Bahia, Brazil. According to body mass index (BMI), these women were classified as either eutrophic or overweight. In the eutrophic females, the IL-10 / IL-17A ratio was increased when compared to those overweight. In addition, IL-17 correlated negatively with HDL and positively with total cholesterol, LDL, triglycerides, VLDL, and glucose in the eutrophic ones, but not in the overweight individuals. IL-10 also showed differences in the correlation pattern observed between the groups, since for this eutrophic cytokine, it presented positive correlation with the waist circumference, waist/height ratio, and negative association with IL-17, while in overweight elderly women, it was not observed such pattern. Hence, this work demonstrates how the amount of fat mass interferes with the balance of cytokines, especially IL-10 and IL-17, and how it may exert an effect on biochemical parameters and risk factors associated with T2DM and SAH.


Assuntos
Composição Corporal/fisiologia , Diabetes Mellitus Tipo 2/etiologia , Hipertensão/etiologia , Interleucina-10/metabolismo , Interleucina-17/metabolismo , Tecido Adiposo/fisiologia , Idoso , Idoso de 80 Anos ou mais , Pressão Arterial/fisiologia , Biomarcadores/metabolismo , Índice de Massa Corporal , Diabetes Mellitus Tipo 2/fisiopatologia , Feminino , Humanos , Hipertensão/fisiopatologia , Inflamação/fisiopatologia , Pessoa de Meia-Idade , Sobrepeso/fisiopatologia , Fatores de Risco , Circunferência da Cintura/fisiologia
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