Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Plasma membrane preassociation drives ß-arrestin coupling to receptors and activation.

Grimes, Jak; Koszegi, Zsombor; Lanoiselée, Yann; Miljus, Tamara; O'Brien, Shannon L; Stepniewski, Tomasz M; Medel-Lacruz, Brian; Baidya, Mithu; Makarova, Maria; Mistry, Ravi; Goulding, Joëlle; Drube, Julia; Hoffmann, Carsten; Owen, Dylan M; Shukla, Arun K; Selent, Jana; Hill, Stephen J; Calebiro, Davide.

Cell ; 186(10): 2238-2255.e20, 2023 05 11.

Artigo em Inglês | MEDLINE | ID: mdl-37146613

2.

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.

Sveidahl Johansen, Olivia; Ma, Tao; Hansen, Jakob Bondo; Markussen, Lasse Kruse; Schreiber, Renate; Reverte-Salisa, Laia; Dong, Hua; Christensen, Dan Ploug; Sun, Wenfei; Gnad, Thorsten; Karavaeva, Iuliia; Nielsen, Thomas Svava; Kooijman, Sander; Cero, Cheryl; Dmytriyeva, Oksana; Shen, Yachen; Razzoli, Maria; O'Brien, Shannon L; Kuipers, Eline N; Nielsen, Carsten Haagen; Orchard, William; Willemsen, Nienke; Jespersen, Naja Zenius; Lundh, Morten; Sustarsic, Elahu Gosney; Hallgren, Cecilie Mørch; Frost, Mikkel; McGonigle, Seth; Isidor, Marie Sophie; Broholm, Christa; Pedersen, Oluf; Hansen, Jacob Bo; Grarup, Niels; Hansen, Torben; Kjær, Andreas; Granneman, James G; Babu, M Madan; Calebiro, Davide; Nielsen, Søren; Rydén, Mikael; Soccio, Raymond; Rensen, Patrick C N; Treebak, Jonas Thue; Schwartz, Thue Walter; Emanuelli, Brice; Bartolomucci, Alessandro; Pfeifer, Alexander; Zechner, Rudolf; Scheele, Camilla; Mandrup, Susanne.

Cell ; 184(13): 3502-3518.e33, 2021 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-34048700

3.

G protein-coupled receptor-G protein interactions: a single-molecule perspective.

Calebiro, Davide; Koszegi, Zsombor; Lanoiselée, Yann; Miljus, Tamara; O'Brien, Shannon.

Physiol Rev ; 101(3): 857-906, 2021 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-33331229

4.

Heterotrimeric G Protein Subunit Gαq Is a Master Switch for GßÎ³-Mediated Calcium Mobilization by Gi-Coupled GPCRs.

Pfeil, Eva Marie; Brands, Julian; Merten, Nicole; Vögtle, Timo; Vescovo, Maddalena; Rick, Ulrike; Albrecht, Ina-Maria; Heycke, Nina; Kawakami, Kouki; Ono, Yuki; Ngako Kadji, Francois Marie; Hiratsuka, Suzune; Aoki, Junken; Häberlein, Felix; Matthey, Michaela; Garg, Jaspal; Hennen, Stephanie; Jobin, Marie-Lise; Seier, Kerstin; Calebiro, Davide; Pfeifer, Alexander; Heinemann, Akos; Wenzel, Daniela; König, Gabriele M; Nieswandt, Bernhard; Fleischmann, Bernd K; Inoue, Asuka; Simon, Katharina; Kostenis, Evi.

Mol Cell ; 80(6): 940-954.e6, 2020 12 17.

Artigo em Inglês | MEDLINE | ID: mdl-33202251

5.

G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level.

Calebiro, Davide; Grimes, Jak.

Annu Rev Pharmacol Toxicol ; 60: 73-87, 2020 01 06.

Artigo em Inglês | MEDLINE | ID: mdl-31539479

6.

Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.

Sungkaworn, Titiwat; Jobin, Marie-Lise; Burnecki, Krzysztof; Weron, Aleksander; Lohse, Martin J; Calebiro, Davide.

Nature ; 550(7677): 543-547, 2017 10 26.

Artigo em Inglês | MEDLINE | ID: mdl-29045395

7.

Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells.

Buenaventura, Teresa; Bitsi, Stavroula; Laughlin, William E; Burgoyne, Thomas; Lyu, Zekun; Oqua, Affiong I; Norman, Hannah; McGlone, Emma R; Klymchenko, Andrey S; Corrêa, Ivan R; Walker, Abigail; Inoue, Asuka; Hanyaloglu, Aylin; Grimes, Jak; Koszegi, Zsombor; Calebiro, Davide; Rutter, Guy A; Bloom, Stephen R; Jones, Ben; Tomas, Alejandra.

PLoS Biol ; 17(8): e3000097, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31430273

8.

Genomic and sequence variants of protein kinase A regulatory subunit type 1ß (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.

Drougat, Ludivine; Settas, Nikolaos; Ronchi, Cristina L; Bathon, Kerstin; Calebiro, Davide; Maria, Andrea Gutierrez; Haydar, Sara; Voutetakis, Antonios; London, Edra; Faucz, Fabio R; Stratakis, Constantine A.

Genet Med ; 23(1): 174-182, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32895490

9.

Detecting Transient Trapping from a Single Trajectory: A Structural Approach.

Lanoiselée, Yann; Grimes, Jak; Koszegi, Zsombor; Calebiro, Davide.

Entropy (Basel) ; 23(8)2021 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-34441183

10.

Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells.

Treppiedi, Donatella; Mangili, Federica; Giardino, Elena; Catalano, Rosa; Locatelli, Marco; Lania, Andrea Gerardo; Spada, Anna; Arosio, Maura; Calebiro, Davide; Mantovani, Giovanna; Peverelli, Erika.

Neuroendocrinology ; 110(7-8): 642-652, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-31574507

11.

Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of µ-Opioid Receptor Dimerization.

Gentzsch, Christian; Seier, Kerstin; Drakopoulos, Antonios; Jobin, Marie-Lise; Lanoiselée, Yann; Koszegi, Zsombor; Maurel, Damien; Sounier, Rémy; Hübner, Harald; Gmeiner, Peter; Granier, Sébastien; Calebiro, Davide; Decker, Michael.

Angew Chem Int Ed Engl ; 59(15): 5958-5964, 2020 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-31808251

12.

The Activation Mechanism of Glycoprotein Hormone Receptors with Implications in the Cause and Therapy of Endocrine Diseases.

Brüser, Antje; Schulz, Angela; Rothemund, Sven; Ricken, Albert; Calebiro, Davide; Kleinau, Gunnar; Schöneberg, Torsten.

J Biol Chem ; 291(2): 508-20, 2016 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-26582202

13.

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

Beuschlein, Felix; Fassnacht, Martin; Assié, Guillaume; Calebiro, Davide; Stratakis, Constantine A; Osswald, Andrea; Ronchi, Cristina L; Wieland, Thomas; Sbiera, Silviu; Faucz, Fabio R; Schaak, Katrin; Schmittfull, Anett; Schwarzmayr, Thomas; Barreau, Olivia; Vezzosi, Delphine; Rizk-Rabin, Marthe; Zabel, Ulrike; Szarek, Eva; Salpea, Paraskevi; Forlino, Antonella; Vetro, Annalisa; Zuffardi, Orsetta; Kisker, Caroline; Diener, Susanne; Meitinger, Thomas; Lohse, Martin J; Reincke, Martin; Bertherat, Jérome; Strom, Tim M; Allolio, Bruno.

N Engl J Med ; 370(11): 1019-28, 2014 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-24571724

14.

Correction: Genomic and sequence variants of protein kinase A regulatory subunit type 1ß (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.

Drougat, Ludivine; Settas, Nikolaos; Ronchi, Cristina L; Bathon, Kerstin; Calebiro, Davide; Maria, Andrea Gutierrez; Haydar, Sara; Voutetakis, Antonios; London, Edra; Faucz, Fabio R; Stratakis, Constantine A.

Genet Med ; 23(1): 239, 2021 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-33082560

15.

Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization.

Calebiro, Davide; Rieken, Finn; Wagner, Julia; Sungkaworn, Titiwat; Zabel, Ulrike; Borzi, Alfio; Cocucci, Emanuele; Zürn, Alexander; Lohse, Martin J.

Proc Natl Acad Sci U S A ; 110(2): 743-8, 2013 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-23267088

16.

Cell biology: Receptor signals come in waves.

Lohse, Martin J; Calebiro, Davide.

Nature ; 495(7442): 457-8, 2013 Mar 28.

Artigo em Inglês | MEDLINE | ID: mdl-23515157

17.

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells.

Werthmann, Ruth C; Volpe, Silvia; Lohse, Martin J; Calebiro, Davide.

FASEB J ; 26(5): 2043-8, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22291442

18.

Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling.

Ast, Julia; Nasteska, Daniela; Fine, Nicholas H F; Nieves, Daniel J; Koszegi, Zsombor; Lanoiselée, Yann; Cuozzo, Federica; Viloria, Katrina; Bacon, Andrea; Luu, Nguyet T; Newsome, Philip N; Calebiro, Davide; Owen, Dylan M; Broichhagen, Johannes; Hodson, David J.

Nat Commun ; 14(1): 301, 2023 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-36653347

19.

Filamin A organizes Î³aminobutyric acid type B receptors at the plasma membrane.

Jobin, Marie-Lise; Siddig, Sana; Koszegi, Zsombor; Lanoiselée, Yann; Khayenko, Vladimir; Sungkaworn, Titiwat; Werner, Christian; Seier, Kerstin; Misigaiski, Christin; Mantovani, Giovanna; Sauer, Markus; Maric, Hans M; Calebiro, Davide.

Nat Commun ; 14(1): 34, 2023 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-36596803

20.

TSH Pulses Finely Tune Thyroid Hormone Release and TSH Receptor Transduction.

Guillou, Anne; Kemkem, Yasmine; Lafont, Chrystel; Fontanaud, Pierre; Calebiro, Davide; Campos, Pauline; Bonnefont, Xavier; Fiordelisio-Coll, Tatiana; Wang, Ying; Brûlé, Emilie; Bernard, Daniel J; Le Tissier, Paul; Steyn, Frederik; Mollard, Patrice.

Endocrinology ; 165(1)2023 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-37934802

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