RESUMO
An evaluation and review of a structurally related group of fragrance materials.
Assuntos
Acetatos/química , Acetatos/toxicidade , Perfumes/química , Perfumes/toxicidade , Acetatos/farmacocinética , Animais , Humanos , Hidrocarbonetos Cíclicos/química , Hidrocarbonetos Cíclicos/farmacocinética , Hidrocarbonetos Cíclicos/toxicidade , Perfumes/farmacocinéticaRESUMO
An evaluation and review of a structurally related group of fragrance materials.
Assuntos
Cinamatos/toxicidade , Perfumes/toxicidade , Propanóis/toxicidade , Pele/efeitos dos fármacos , Administração Cutânea , Alérgenos/classificação , Alérgenos/farmacocinética , Alérgenos/toxicidade , Animais , Cinamatos/classificação , Cinamatos/farmacocinética , Qualidade de Produtos para o Consumidor , Ésteres , Humanos , Noxas/classificação , Noxas/farmacocinética , Noxas/toxicidade , Perfumes/classificação , Perfumes/farmacocinética , Propanóis/classificação , Propanóis/farmacocinética , Medição de Risco , Pele/metabolismo , Absorção Cutânea , Testes de Irritação da Pele , Testes Cutâneos , Testes de ToxicidadeRESUMO
An evaluation and review of a structurally related group of fragrance materials.
Assuntos
Norisoprenoides/toxicidade , Perfumes/toxicidade , Pele/efeitos dos fármacos , Administração Cutânea , Administração Oral , Alérgenos/classificação , Alérgenos/farmacocinética , Alérgenos/toxicidade , Animais , Qualidade de Produtos para o Consumidor , Relação Dose-Resposta a Droga , Prova Pericial , Feminino , Humanos , Masculino , Norisoprenoides/química , Norisoprenoides/farmacocinética , Noxas/classificação , Noxas/farmacocinética , Noxas/toxicidade , Perfumes/classificação , Perfumes/farmacocinética , Medição de Risco , Pele/metabolismo , Pele/patologia , Absorção Cutânea , Testes de Irritação da Pele , Testes de ToxicidadeRESUMO
An evaluation and review of a structurally related group of fragrance materials.
Assuntos
Inibidores de Ciclo-Oxigenase/toxicidade , Noxas/toxicidade , Perfumes/toxicidade , Salicilatos/toxicidade , Pele/efeitos dos fármacos , Alérgenos/classificação , Alérgenos/farmacocinética , Alérgenos/toxicidade , Animais , Qualidade de Produtos para o Consumidor , Inibidores de Ciclo-Oxigenase/classificação , Inibidores de Ciclo-Oxigenase/farmacocinética , Relação Dose-Resposta a Droga , Prova Pericial , Humanos , Noxas/classificação , Noxas/farmacocinética , Perfumes/farmacocinética , Medição de Risco , Salicilatos/classificação , Salicilatos/farmacocinética , Pele/metabolismo , Absorção Cutânea , Testes de Irritação da Pele , Testes Cutâneos , Testes de ToxicidadeRESUMO
This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Canfanos/análise , Perfumes/análise , Valeratos/análise , Animais , Canfanos/toxicidade , Química/organização & administração , Qualidade de Produtos para o Consumidor , Bases de Dados de Compostos Químicos , Humanos , Perfumes/toxicidade , Sistema de Registros , Testes de Toxicidade , Valeratos/toxicidadeRESUMO
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Ácido Acético/química , Ésteres/química , Perfumes/química , Animais , Química/organização & administração , Qualidade de Produtos para o Consumidor , Bases de Dados de Compostos Químicos , Humanos , Perfumes/toxicidade , Sistema de RegistrosRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog, benzyl acetate (CAS # 140-11-4), show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using benzyl acetate (CAS # 140-11-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Acetatos/toxicidade , Compostos de Benzil/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Acetatos/química , Animais , Compostos de Benzil/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog linalyl phenylacetate (CAS # 7143-69-3) show that this material does not have skin sensitization potential. The repeated dose toxicity endpoint was completed using linalyl cinnamate (CAS # 78-37-5) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using linalool (CAS # 78-70-6), dehydrolinalool (CAS # 29171-20-8), benzoic acid (CAS # 65-85-0) and sodium benzoate (CAS # 532-32-1) as suitable read across analogs, which provided a MOE > 100. The local respiratory toxicity endpoint was completed using linalool (CAS # 78-70-6) and benzoic acid (CAS # 65-85-0) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework along with data from the suitable read across analog linalyl cinnamate (CAS # 78-375).
Assuntos
Benzoatos/toxicidade , Monoterpenos/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Benzoatos/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Monoterpenos/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog linalool (CAS # 78-70-6) show that this material is not genotoxic nor does it have skin sensitization potential and also provided a MOE > 100 for the local respiratory endpoint. The repeated dose, developmental and reproductive toxicity endpoints were completed using nerolidol (isomer unspecified, CAS # 7212-44-4) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Álcoois Graxos/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Álcoois Graxos/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Developmental toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 100 mg/kg/day. A gavage developmental toxicity study conducted in rats on a suitable read across analog resulted in aMOE of 3571 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Acetatos/toxicidade , Compostos de Benzil/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Acetatos/química , Animais , Compostos de Benzil/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 37.5 mg/kg/day. A gavage 13-week subchronic toxicity study conducted in mice resulted in a MOE of 5769 while considering 38.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Eugenol/análogos & derivados , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Eugenol/química , Eugenol/toxicidade , Camundongos , Nível de Efeito Adverso não Observado , Perfumes/química , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Inseticidas/toxicidade , Monoterpenos/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Monoterpenos Acíclicos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Inseticidas/química , Monoterpenos/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Reproductive toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 230 mg/kg/day. A gavage multigenerational continuous breeding study conducted in rats on a suitable read across analog resulted in a MOE of 12,105 while considering 22.6% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Anti-Infecciosos/toxicidade , Eugenol/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Anti-Infecciosos/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Eugenol/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 14.5 mg/kg/day. A dietary 2-year chronic toxicity study conducted in rats on a suitable read across analog resulted in a MOE of 1318 while considering 78.7% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Compostos de Benzil/toxicidade , Perfumes/toxicidade , Propionatos/toxicidade , Testes de Toxicidade/métodos , Animais , Compostos de Benzil/química , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Nível de Efeito Adverso não Observado , Perfumes/química , Propionatos/química , Ratos , Medição de RiscoRESUMO
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 10 mg/kg/day. A dietary 90-day subchronic toxicity study conducted in rats resulted in a MOE of 182 while assuming 100% absorption from skin contact and inhalation. A MOE of >100 is deemed acceptable.
Assuntos
Norisoprenoides/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Nível de Efeito Adverso não Observado , Norisoprenoides/química , Perfumes/química , Ratos , Medição de RiscoRESUMO
This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The repeated dose, developmental and reproductive, and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Perfumes/toxicidade , Terpenos/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Monoterpenos Cicloexânicos , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de Risco , Terpenos/químicaRESUMO
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the suitable read across analog 2-ethylhexanol (CAS # 104-76-7) show that this material is not genotoxic. Data from the suitable read across analog isopropyl alcohol (CAS # 67-63-0) show that this material does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using 2-ethylhexanol (CAS # 104-76-7) and 1-heptanol, 2-propyl (CAS # 10042-59-8) as suitable read across analogs, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using 2-ethyl-hexanol (CAS # 104-76-7) and isobutyl alcohol (CAS # 78-83-1) as suitable read across analogs, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.
Assuntos
Hexanóis/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Hexanóis/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
: The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic nor does it have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The repeated dose toxicity endpoint was completed using ethylene dodecanedioate (CAS # 54982-83-1) as a suitable read across analog, which provided a MOE > 100. The developmental and reproductive toxicity endpoint was completed using oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2) as a suitable read across analog, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra along with data on the target material. The environmental endpoint was completed as described in the RIFM Framework along with data on the suitable read across analog oxacyclohexadec-12-en-2-one, (12E)- (CAS # 111879-80-2).
Assuntos
Éteres Cíclicos/toxicidade , Perfumes/toxicidade , Testes de Toxicidade/métodos , Animais , Qualidade de Produtos para o Consumidor , Dano ao DNA/efeitos dos fármacos , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Determinação de Ponto Final , Éteres Cíclicos/química , Nível de Efeito Adverso não Observado , Perfumes/química , Ratos , Medição de RiscoRESUMO
The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog 2-butyloctan-1-ol (CAS # 3913-02-8) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 and 1.4 mg/day, respectively). The developmental and repeat dose toxicity endpoints were completed data on the target material which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.