Detalhe da pesquisa
1.
Discovery of a novel series of selective macrocyclic PKCTheta inhibitors.
Bioorg Med Chem Lett
; 100: 129630, 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38307441
2.
Author Correction: MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
Nat Chem Biol
; 15(12): 1249, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31645751
3.
Covalent Small Molecules as Enabling Platforms for Drug Discovery.
Chembiochem
; 21(8): 1080-1100, 2020 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31833626
4.
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
Nat Chem Biol
; 14(11): 1032-1042, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297875
5.
Dual Roles for Potassium Hydride in Haloarene Reduction: CSNAr and Single Electron Transfer Reduction via Organic Electron Donors Formed in Benzene.
J Am Chem Soc
; 140(36): 11510-11518, 2018 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30119605
6.
Selectively Targeting the Kinome-Conserved Lysine of PI3Kδ as a General Approach to Covalent Kinase Inhibition.
J Am Chem Soc
; 140(3): 932-939, 2018 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232121
7.
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Nat Chem Biol
; 11(8): 611-7, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26075522
8.
Reductive conjugate addition nitro-Mannich route for the stereoselective synthesis of 1,2,3,4-tetrahydroquinoxalines.
Org Biomol Chem
; 14(35): 8270-7, 2016 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527672
9.
Hydrogen isotope exchange with highly active iridium(I) NHC/phosphine complexes: a comparative counterion study.
J Labelled Comp Radiopharm
; 59(14): 601-603, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27460856
10.
Stereoselective synthesis of 1,2-diamine containing indolines by a conjugate addition nitro-Mannich reaction.
Org Biomol Chem
; 13(1): 170-7, 2015 Jan 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25351774
11.
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
J Biol Chem
; 288(39): 28195-206, 2013 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23935099
12.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett
; 22(16): 5222-6, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22801646
13.
MOG analogues to explore the MCT2 pharmacophore, α-ketoglutarate biology and cellular effects of N-oxalylglycine.
Commun Biol
; 5(1): 877, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028752
14.
Acetylation of the Catalytic Lysine Inhibits Kinase Activity in PI3Kδ.
ACS Chem Biol
; 16(9): 1644-1653, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34397208
15.
Discovery of GSK251: A Highly Potent, Highly Selective, Orally Bioavailable Inhibitor of PI3Kδ with a Novel Binding Mode.
J Med Chem
; 64(18): 13780-13792, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34510892
16.
A Turing Test for Molecular Generators.
J Med Chem
; 63(20): 11964-11971, 2020 10 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32955254
17.
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Bioorg Med Chem Lett
; 19(9): 2504-8, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19349179
18.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
J Med Chem
; 62(19): 8796-8808, 2019 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31497959
19.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
20.
Base-Controlled Diastereoselective Synthesis of Either anti- or syn-ß-Aminonitriles.
Org Lett
; 19(7): 1918-1921, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322059