Dental and periodontal dimensions stability after esthetic clinical crown lengthening surgery: a 12-month clinical study.

OBJECTIVES: To evaluate the stability of periodontal tissues 3 (T3), 6 (T6), and 12 (T12) months after esthetic crown lengthening (ACL) and the possible correlations between changes in those structures. MATERIALS AND METHODS: Twenty individuals were evaluated through clinical assessment, photography, and tomography. Measurements included gingival margin (GM), clinical crown length (CCL), interdental papilla height (PH) and width (PW), gingival thickness (GT), bone thickness (BT), probing depth (PD), distance between alveolar crest and GM, distance between alveolar crest and cementoenamel junction. Nonparametric and correlation statistics were performed (p < 0.05). RESULTS: CCL at T0 was 7.42 ± 0.70 mm and increased to 9.48 ± 0.49 mm immediately after ACL, but it decreased to 8.93 ± 0.65 mm at T12. PD decreased 0.60 mm from T0 to T6, and it increased 0.39 mm from T6 to T12. BT decreased 0.20 mm, while GT increased 0.29 mm from T0 to T12. Both PW and PH showed enlargement in T12. A positive moderate correlation was found between CCL/T0 and CCL/T12, GT/T0 and AC-GM/T12, BT/T0 and GT/T12. A few negative moderate correlations were PD/T0 and CCL/T12, PD/T0 and PH/T0, PD/T0 and BT/T12. CONCLUSIONS: ACL procedure was effective. Although some rebound occurred, that was not clinically important. PD tended to reestablish its original length, partially due to a migration of GM during the healing period. Besides, a thickening of supracrestal soft tissues was observed. CLINICAL RELEVANCE: The present study centers on the factors influencing the stability of periodontal tissues after esthetic crown lengthening, underscoring the procedure's influence on esthetics and biology and the need for careful treatment planning.

Expression of inflammatory mediators in periodontitis and T2D patients: a systematic review and meta-analysis.

The high concentration of glucose in the blood in Type 2 diabetes (T2D) may be related to either insulin resistance or insulin deficiency. Moreover, the literature points to periodontitis as the main oral disease caused by glycemia imbalance. The quantification of inflammatory markers in blood or saliva samples of T2D patients may represent a valuable tool in revealing how well an individual's immune system can respond to injuries and periodontal treatment. In addition, an evaluation of the cytokine expression is extremely relevant to help understand the connection between periodontitis and T2D. This systematic review and meta-analysis aimed to evaluate the expression of inflammatory markers in T2D patients with periodontitis, compared with non-diabetic patients with periodontitis. A total of 3,894 studies were retrieved after a systematic literature search, 15 of which were included in the systematic review, and 4 of these 15, in the meta-analysis. The results did not indicate any statistical difference between the groups regarding TNF-α and IL-6 markers. T2D patients with periodontitis had increased levels of IL-10, compared with non-diabetic individuals with periodontitis (p = 0.003). On the other hand, the IL-4 concentration in non-diabetic individuals with periodontitis was high, compared with the T2D group (p< 0.001). Several studies did not include quantitative results and were excluded from the meta-analysis. The high IL-10 expression and low IL-4 expression in the T2D group suggest an association between the level of these markers and the impairment of the immune response in T2D patients with periodontitis.

Expression of inflammatory mediators in periodontitis and T2D patients: a systematic review and meta-analysis

Abstract The high concentration of glucose in the blood in Type 2 diabetes (T2D) may be related to either insulin resistance or insulin deficiency. Moreover, the literature points to periodontitis as the main oral disease caused by glycemia imbalance. The quantification of inflammatory markers in blood or saliva samples of T2D patients may represent a valuable tool in revealing how well an individual's immune system can respond to injuries and periodontal treatment. In addition, an evaluation of the cytokine expression is extremely relevant to help understand the connection between periodontitis and T2D. This systematic review and meta-analysis aimed to evaluate the expression of inflammatory markers in T2D patients with periodontitis, compared with non-diabetic patients with periodontitis. A total of 3,894 studies were retrieved after a systematic literature search, 15 of which were included in the systematic review, and 4 of these 15, in the meta-analysis. The results did not indicate any statistical difference between the groups regarding TNF-α and IL-6 markers. T2D patients with periodontitis had increased levels of IL-10, compared with non-diabetic individuals with periodontitis (p = 0.003). On the other hand, the IL-4 concentration in non-diabetic individuals with periodontitis was high, compared with the T2D group (p< 0.001). Several studies did not include quantitative results and were excluded from the meta-analysis. The high IL-10 expression and low IL-4 expression in the T2D group suggest an association between the level of these markers and the impairment of the immune response in T2D patients with periodontitis.

Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis.

OBJECTIVE: To investigate the effects of nonsurgical periodontal therapy on levels of high-sensitivity C-reactive protein in the sera and its association with body mass index and high density lipoprotein in subjects with severe periodontitis. METHODS: Sera from 28 subjects (mean age: 34.36±6.24; 32% men) with severe periodontitis and 27 healthy controls (mean age: 33.18±6.42; 33% men) were collected prior to periodontal therapy. Blood samples were obtained from 23 subjects who completed therapy (9-12 months). Oral and systemic parameters such as the number of blood cells, glucose examination, lipid profile, and high-sensitivity C-reactive protein levels accessed by high-sensitivity immunonephelometry assay, were included. RESULTS: Before therapy, in the periodontitis group, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/dL was statistically lower than in the control group (P<0.0216). After therapy, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/dL was significantly higher (65.22%) (P<0.0339). The mean value for body mass index was statistically lower in subjects with high-sensitivity C-reactive protein <0.3 mg/dL (24.63±4.19), compared with those with high-sensitivity C-reactive protein >0.3 mg/dL (28.91±6.03) (P<0.0411). High density lipoprotein presented a mean value statistically higher after therapy (P<0.0027). CONCLUSION: In systemically healthy subjects with periodontitis, periodontal therapy was associated with decreased levels of circulating high-sensitivity C-reactive protein and increase of high density lipoprotein in serum. The clinical trial was registered at http://www.clinicaltrials.gov.br/, No. RBR-24T799.

Abordagem interdisciplinar no tratamento das recessões gengivais: relato de caso / Interdisciplinary approach in the treatment of gingival recessions: case report

Objetivo: o artigo faz uma revisão literária com abordagem interdisciplinar acerca do tratamento das recessões gengivais, por meio de relato de caso, exemplificando características clínicas e protocolo de resolução. Relato de caso: paciente com queixa principal de insatisfação estética na região dos dentes 11 e 21,em que se observou a presença de recessões gengivais rasas associadas à esses, sendo maior a do incisivo central superior esquerdo com a presença de coroas provisórias acrílicas com contornos fisiológicos inadequados e núcleos metálicos fundidos. O plano de tratamento indicado inicialmente foi deslize coronal do retalho com enxerto de tecido conjuntivo na região dos dentes 11 e 21, com objetivo de recobrimento radicular e confecção de novas coroas provisórias. Considerações finais: a técnica cirúrgica do envelope, associada ao enxerto de tecido conjuntivo, promoveu ganho clínico de inserção e recobrimento radicular, representando uma alternativa viável e altamente previsível para o tratamento das recessões gengivais, principalmente aquelas relacionadas aos defeitos classe I e II de Miller. O tratamento interdisciplinar associando cirurgia periodontal e tratamento protético contribuiu para o aumento de espessura da mucosa ceratinizada e a estabilidade da margem gengival respectivamente; coroas provisórias confeccionadas com contornos fisiológicos dão suporte à margem gengival e, consequentemente, favorecem a saúde periodontal.(AU)

Objective: The study presents a literature review with an interdisciplinary approach to the treatment of gingival recessions, by means of a case report, exemplifying their clinical characteristics and resolution protocol. Case report: Patient with the major complaint of aesthetic dissatisfaction in the region of teeth 11 and 21, which showed the presence of shallow gingival recession associated with said teeth. The greatest recession was in the upper left central incisor with the presence of temporary acrylic crowns, inadequate physiological contours, and molten metal nuclei. The initial treatment plan was the coronal slide of the flap with connective tissue graft in the region of teeth 11 and 21 to cover the root and the production of new temporary crowns. Final Considerations: The surgical technique of the envelope associated with the connective tissue graft promoted the clinical gain of insertion and root coverage, representing a viable and highly predictable alternative for the treatment of gingival recessions, especially those related to Miller class I and II defects. The interdisciplinary treatment associating periodontal surgery and prosthetic treatment contributed to increase the thickness of keratinized mucosa and to the stability of the gingival margin, respectively. Temporary crowns produced with physiological contours support the gingival margin and consequently favor periodontal health.(AU)

A influência da doença periodontal e a manipulação dos tecidos periodontais na bacteremia sistêmica: uma revisão de literatura / The influence of periodontal disease and the manipulation of periodontal tissues on systemic bacteremia: a review of the literature

Periodontal disease is the most prevalent oral infection in patients admitted to intensive care units. The periodontium is surrounded by a multitude of lymphatic vessels. Through this path, the lymphatic fluid mixes with the venous blood, resulting in an invasion of bacteria in the circulatory system, even for a short period of time. Periodontal bacteria, in addition to entering the circulatory system, produce inflammatory mediators that are generally not limited to periodontal tissues. Through these and other processes, it is possible to observe the relationship between periodontal diseases and systemic diseases. The objective of this review was to observe the pathways between periodontal disease and systemic events, emphasizing the bacteremia caused by the manipulation of periodontal tissues in patients with periodontitis. A search was performed on the Pubmed, Lilacs and Scielo databases, using the English descriptors "periodontal diseases", "periodontitis", "bacteremia", "bacteraemia" and "periodontal therapy". Studies show that periodontal disease and manipulation of periodontal tissues are capable of promoting bacteremia and of influencing systemic diseases. It was also concluded that the studies present a heterogeneous methodology, which suggests the need for greater standardization to better compare the data (AU)

A doença periodontal é a infecção bucal de maior prevalência em pacientes internados em unidades de terapia intensiva. O periodonto é cercado por uma infinidade de vasos linfáticos. Por este trajeto, o fluido linfático se mistura ao sangue venoso, resultando numa invasão de bactérias no sistema circulatório, ainda que por curto período de tempo. As bactérias periodontais, além de adentrarem no sistema circulatório, produzem mediadores inflamatórios que, geralmente, não se limitam aos tecidos periodontais. Por meio desses e outros processos, é possível observar a relação das doenças periodontais com as doenças sistêmicas. O objetivo desta revisão foi observar as vias de ligação entre a doença periodontal e os eventos sistêmicos, salientando a bacteremia originada da manipulação dos tecidos periodontais em pacientes com periodontite. Foi realizada uma busca nas bases de dados Pubmed, Lilacs e Scielo, utilizando os descritores em inglês "periodontal diseases", "periodontitis", "bacteremia", "bacteraemia", "periodontal therapy". Estudos mostram que a doença periodontal e a manipulação dos tecidos periodontais são capazes de promover a bacteremia e de influenciar doenças sistêmicas. Concluiu-se ainda, que os estudos apresentam uma metodologia heterogênea, o que sugere a necessidade de maior padronização para melhor comparação dos dados (AU)

Effects of periodontal therapy on C-reactive protein and HDL in serum of subjects with periodontitis / Efeitos da terapia periodontal sobre proteína C-reativa e HDL no soro de indivíduos com periodontite

Objective: To investigate the effects of nonsurgical periodontal therapy on levels of high-sensitivity C-reactive protein in the sera and its association with body mass index and high density lipoprotein in subjects with severe periodontitis. Methods: Sera from 28 subjects (mean age: 34.36±6.24; 32% men) with severe periodontitis and 27 healthy controls (mean age: 33.18±6.42; 33% men) were collected prior to periodontal therapy. Blood samples were obtained from 23 subjects who completed therapy (9-12 months). Oral and systemic parameters such as the number of blood cells, glucose examination, lipid profile, and high-sensitivity C-reactive protein levels accessed by high-sensitivity immunonephelometry assay, were included. Results: Before therapy, in the periodontitis group, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/dL was statistically lower than in the control group (P<0.0216). After therapy, the ratio of subjects with high-sensitivity C-reactive protein <0.3 mg/dL was significantly higher (65.22%) (P<0.0339). The mean value for body mass index was statistically lower in subjects with high-sensitivity C-reactive protein <0.3 mg/dL (24.63±4.19), compared with those with high-sensitivity C-reactive protein >0.3 mg/dL (28.91±6.03) (P<0.0411). High density lipoprotein presented a mean value statistically higher after therapy (P<0.0027). Conclusion: In systemically healthy subjects with periodontitis, periodontal therapy was associated with decreased levels of circulating high-sensitivity C-reactive protein and increase of high density lipoprotein in serum. The clinical trial was registered at http://www.clinicaltrials.gov.br/, No. RBR-24T799. .

Objetivo: Investigar os efeitos da terapia periodontal não cirúrgica sobre níveis de proteína C-reativa ultrassensível no soro e associação dessa com o índice de massa corporal e lipoproteína de alta densidade em indivíduos com periodontite grave. Métodos: O soro de 28 indivíduos (idade média: 34,36±6,24; 32% homens) com periodontite grave e 27 controles saudáveis (idade média: 33,18±6,42; 33% homens) foi coletado antes da terapia periodontal. Novas amostras de sangue foram obtidas dos 23 indivíduos que completaram o tratamento periodontal (entre 9-12 meses após). Parâmetros bucais e sistêmicos, tais como contagem do número de células do sangue, exame complementar de glicose, lipidograma e níveis de proteína C-reativa ultrassensível, acessados pelo método de nefelometria (imunonefelometria ultrassensível) foram incluídos. Resultados: Antes da terapia, a proporção de indivíduos com proteína C-reativa ultrassensível <0,3 mg/dL no grupo periodontite foi estatisticamente menor que a proporção de indivíduos com proteína C-reativa ultrassensível <0,3 mg/ dL nos controles (P<0,0216). Após a terapia, a proporção de indivíduos com proteína C-reativa ultrassensível <0,3 mg/dL foi estatisticamente maior (65,22%) (P<0,0339). O valor médio para índice de massa corporal foi estatisticamente menor nos indivíduos com proteína C-reativa ultrassensível <0,3 mg/dL (24,63±4,19), comparados àqueles com proteína C-reativa ultrassensível ≥0,3 mg/dL (28,91±6,03) (P<0,0411). O colesterol lipoproteína de alta densidade pós-terapia apresentou valor médio estatisticamente maior (P<0,0027). Conclusão: Em indivíduos com periodontite ...