RESUMO
The crystal structures of ANb3Br7S (A = Rb and Cs) have been refined by single crystal X-ray diffraction, and are found to form highly anisotropic materials based on chains of the triangular Nb3 cluster core. The Nb3 cluster core contains seven valence electrons, six of them being assigned to Nb-Nb bonds within the Nb3 triangle and one unpaired d electron. The presence of this surplus electron gives rise to the formation of correlated electronic states. The connectivity in the structures is represented by one-dimensional [Nb3Br7S]- chains, containing a sulphur atom capping one face (µ3) of the triangular niobium cluster, which is believed to induce an important electronic feature. Several types of studies are undertaken to obtain deeper insight into the understanding of this unusual material: the crystal structure, morphology and elastic properties are analysed, as well the (photo-)electrical properties and NMR relaxation. Electronic structure (DFT) calculations are performed in order to understand the electronic structure and transport in these compounds, and, based on the experimental and theoretical results, we propose that the electronic interactions along the Nb chains are sufficiently one-dimensional to give rise to Luttinger liquid (rather than Fermi liquid) behaviour of the metallic electrons.
RESUMO
Describing long-range energy transport is a crucial step, both toward deepening our knowledge on natural light-harvesting systems and toward developing novel photoactive materials. Here, we combine experiment and theory to resolve and reproduce energy transport on pico- to nanosecond time scales in single H-type supramolecular nanofibers based on carbonyl-bridged triarylamines (CBT). Each nanofiber shows energy transport dynamics over long distances up to â¼1 µm, despite exciton trapping at specific positions along the nanofibers. Using a minimal Frenkel exciton model including disorder, we demonstrate that spatial correlations in the normally distributed site energies are crucial to reproduce the experimental data. In particular, we can observe the long-range and subdiffusive nature of the exciton dynamics as well as the trapping behavior of excitons in specific locations of the nanofiber. This trapping behavior introduces a net directionality or asymmetry in the exciton dynamics as observed experimentally.
RESUMO
The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples and the technical approach to analyze the immunoglobulin genes was of amplifying rearranged variable region genes with the classical direct sequencing of the PCR products followed by cloning. Here, we studied the B cell Ig heavy-chain repertoires by next-generation sequencing (NGS) in 30 NMZL cases. Most of the cases were mutated (20/28; 71.5%) with homologies to the respective germ line genes ranging from 85 to 97, 83%, whereas 8/28 (28.5%) were unmutated. In addition, our results show that NMZL cases have a biased usage of specific immunoglobulin heavy-chain variable (IGHV) region genes. Moreover, we documented intraclonal diversity in all (100%) of the mutated cases and ongoing somatic hypermutations (SHM) have been confirmed by hundreds of reads. We analyzed the mutational pattern to detect and quantify antigen selection pressure and we found a positive selection in 4 cases, whereas in the remaining cases there was an unspecific stimulation. Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL.
Assuntos
Cadeias Pesadas de Imunoglobulinas/genética , Região Variável de Imunoglobulina/genética , Linfoma de Zona Marginal Tipo Células B/patologia , Mutação/genética , Neoplasias Esplênicas/patologia , Idoso , Idoso de 80 Anos ou mais , Linfócitos B/patologia , Feminino , Sequenciamento de Nucleotídeos em Larga Escala/métodos , Humanos , Linfoma de Zona Marginal Tipo Células B/genética , Masculino , Prognóstico , Neoplasias Esplênicas/genética , Neoplasias Esplênicas/imunologiaRESUMO
This error was caused due to the author's oversight and this does not change the views or the results presented in the manuscript.