[Acute pneumopathy caused by exposure to zinc oxide]. / Pneumopathie aiguë au cours d'une exposition à l'oxyde de zinc.

The authors report the case of an acute lung reaction due to an accidental exposition to zinc oxide. This episode showed features of metal fume fever. The bronchoalveolar lavage showed an increased cellularity (1,300 cells/mm3) with 28% neutrophils and 25% eosinophils. The characteristics of pulmonary disease associated with fever associated to exposure to zinc, as well as its pathogenic mechanism are discussed.

[Pulmonary fibroma]. / Fibrome pulmonaire.

The authors report the case of a pulmonary fibroma in a 66 year-old smoker. Intrapulmonary localization of solitary fibrous tumors is rare; these tumors are more frequently described in pleura. Histologically, the presence of spindle cells without nuclear atypy on a collagen background must evoke the diagnosis made difficult by the unusual localization.

[Diffuse interstitial lung disease without pleural involvement and high-dose bromocriptine]. / Pneumopathie interstitielle diffuse sans atteinte pleurale et prise de bromocriptine à forte dose.

Bromocriptine, used in the treatment of acromegaly, hyperprolactinemia and Parkinson's disease, may be responsible in this last case, for pleuro-pulmonary complications in higher doses. Since 1981 about thirty cases were described. It was mostly pleural effusions, pleural thickening and parenchymal lung fibrosis. The prevalence of pleuro-pulmonary diseases is between 2 to 5% after 5 years with bromocriptine that varied in dosage from 20 to 90 mg daily. The patients developed symptoms from nine months to four years. We report a case of a patient treated for one year for Parkinson's disease with daily dose of 105 mg of bromocriptine in whom bilateral pulmonary infiltrate was discovered with a deterioration in the general physical state and dyspnea. There was a favorable clinical and chest roentgenogram outcome following the cessation of treatment, in six months. The hypotheses to explain the pathogenesis of these disorders were always discussed: a vascular theory, an immunological theory or a toxic fibrogenesis induced by the molecule acting on dopaminergic receptors and serotonergic synapses. Now, in our knowledge, these complications justify a clinical and chest roentgenogram follow up for any patients treated with bromocriptine.

[Bronchial casts associated with pulmonary lymphatic anomalies]. / Moules bronchiques associés à des anomalies lymphatiques pulmonaires.

We report a case of a patient who presented with bronchial moulds. The classic causes, particularly bronchopulmonary aspergillosis could not be found. The pulmonary radiology and CT of thorax revealed an alveolar syndrome. Lymphography and lymphoscintigraphy showed evidence of lymphatic anomalies including the non-visualisation of the thoracic canal. In the absence of evidence for other diseases, we would suggest that these anomalies were responsible for the symptomatology.