Detalhe da pesquisa
1.
Detection of isoflavones and phytoestrogen-rich plant extracts binding to estrogen receptor ß using a yeast-based fluorescent assay.
Anal Biochem
; 690: 115529, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38582243
2.
The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function.
FASEB J
; 28(5): 2332-46, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24558196
3.
Synthesis and anticancer cell potential of steroidal 16,17-seco-16,17a-dinitriles: identification of a selective inhibitor of hormone-independent breast cancer cells.
Bioorg Med Chem
; 23(4): 703-11, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25619894
4.
Synthesis, in vitro and in silico anticancer evaluation of novel pyridin-2-yl estra-1,3,5(10)-triene derivatives.
Future Med Chem
; 2024 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38629440
5.
Development of new steroid-based hydrazide and (thio)semicarbazone compounds with anticancer properties.
J Steroid Biochem Mol Biol
; 242: 106545, 2024 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-38762058
6.
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating.
J Biol Chem
; 287(21): 17232-17240, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22474326
7.
17(E)-picolinylidene androstane derivatives as potential inhibitors of prostate cancer cell growth: antiproliferative activity and molecular docking studies.
Bioorg Med Chem
; 21(23): 7257-66, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24148837
8.
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity.
Proc Natl Acad Sci U S A
; 107(20): 9176-81, 2010 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20439752
9.
X-ray structure of human aldo-keto reductase 1C3 in complex with a bile acid fused tetrazole inhibitor: experimental validation, molecular docking and structural analysis.
RSC Med Chem
; 14(2): 341-355, 2023 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36846371
10.
Novel D-modified heterocyclic androstane derivatives as potential anticancer agents: Synthesis, characterization, in vitro and in silico studies.
J Steroid Biochem Mol Biol
; 233: 106362, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37451557
11.
C-terminal domain of chromogranin B regulates intracellular calcium signaling.
J Biol Chem
; 286(52): 44888-96, 2011 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22016391
12.
Hormone receptor binding, selectivity and cytotoxicity of steroid D-homo lactone loaded chitosan nanoparticles for the treatment of breast and prostate cancer cells.
Colloids Surf B Biointerfaces
; 216: 112597, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35636320
13.
Investigation of the Potential of Bile Acid Methyl Esters as Inhibitors of Aldo-keto Reductase 1C2: Insight from Molecular Docking, Virtual Screening, Experimental Assays and Molecular Dynamics.
Mol Inform
; 41(10): e2100256, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393780
14.
Microwave-assisted green synthesis of bile acid derivatives and evaluation of glucocorticoid receptor binding.
RSC Med Chem
; 12(2): 278-287, 2021 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34046616
15.
Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2.
Am J Physiol Renal Physiol
; 297(5): F1310-5, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19726544
16.
Evaluation of A-ring fused pyridine d-modified androstane derivatives for antiproliferative and aldo-keto reductase 1C3 inhibitory activity.
Medchemcomm
; 9(6): 969-981, 2018 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108986
17.
Identification of d-seco modified steroid derivatives with affinity for estrogen receptor α and ß isoforms using a non-transcriptional fluorescent cell assay in yeast.
Steroids
; 130: 22-30, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29224741
18.
Mutagenic mapping of helical structures in the transmembrane segments of the yeast alpha-factor receptor.
J Mol Biol
; 317(5): 765-88, 2002 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11955023
19.
Intensive mutational analysis of G protein-coupled receptors in yeast.
Methods Mol Biol
; 237: 105-20, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-14501043
20.
Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2p.
J Mol Biol
; 418(5): 367-78, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22387470