Detalhe da pesquisa
1.
Human Absorption, Distribution, Metabolism, and Excretion Studies: Origins, Innovations, and Importance.
Drug Metab Dispos
; 51(6): 647-656, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36973000
2.
Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides.
Mol Pharm
; 20(6): 3020-3032, 2023 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37134201
3.
Transporter-Enzyme Interplay in the Pharmacokinetics of PF-06835919, A First-in-class Ketohexokinase Inhibitor for Metabolic Disorders and Non-alcoholic Fatty Liver Disease.
Drug Metab Dispos
; 2022 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35779864
4.
Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes.
Drug Metab Dispos
; 49(10): 947-960, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326140
5.
Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants.
Drug Metab Dispos
; 49(6): 442-450, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811106
6.
Identification and Characterization of a Selective Human Carbonyl Reductase 1 Substrate.
Drug Metab Dispos
; 46(10): 1434-1440, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30068520
7.
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Bioorg Med Chem Lett
; 28(5): 979-984, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29254646
8.
Leveraging of Rifampicin-Dosed Cynomolgus Monkeys to Identify Bile Acid 3-O-Sulfate Conjugates as Potential Novel Biomarkers for Organic Anion-Transporting Polypeptides.
Drug Metab Dispos
; 45(7): 721-733, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28396527
9.
Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates.
J Pharmacol Exp Ther
; 359(1): 142-50, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27481775
10.
Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.
Drug Metab Dispos
; 44(8): 1246-52, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27084892
11.
Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation.
Drug Metab Dispos
; 44(4): 570-5, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26758853
12.
G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.
J Pharmacol Exp Ther
; 348(3): 421-31, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24399854
13.
Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.
Drug Metab Dispos
; 42(10): 1751-60, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25035284
14.
High-throughput cytochrome P450 loss and metabolic intermediate complex assays to aid in designing out of CYP3A inactivation.
Methods Enzymol
; 690: 341-368, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37858534
15.
Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.
Drug Metab Dispos
; 40(4): 772-8, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22259019
16.
Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers.
Clin Pharmacol Ther
; 109(3): 646-657, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32961594
17.
Effective Application of Metabolite Profiling in Drug Design and Discovery.
J Med Chem
; 63(12): 6387-6406, 2020 06 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32097005
18.
Attempting to Unmask the Inhibition of Sulfotransferase 1E1 in 17α-Ethinyl Estradiol Drug Interactions.
J Clin Pharmacol
; 63(8): 875-879, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36919596
19.
Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.
J Med Chem
; 49(24): 6987-7001, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125252
20.
Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
J Steroid Biochem Mol Biol
; 154: 197-205, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303746