Detalhe da pesquisa
1.
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer's Disease in Rat and Dog.
Pharm Res
; 39(7): 1497-1507, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-35704250
2.
Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aß42 prompted by exogenous fibrillary or soluble Aß25-35 in human cortical astrocytes and neurons-therapeutic relevance to Alzheimer's disease.
Biochim Biophys Acta
; 1832(10): 1634-52, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23628734
3.
Evidence that a synthetic amyloid-ß oligomer-binding peptide (ABP) targets amyloid-ß deposits in transgenic mouse brain and human Alzheimer's disease brain.
Biochem Biophys Res Commun
; 445(3): 656-60, 2014 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24569075
4.
A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds ß-amyloid (Aß1-42 ) oligomers.
J Neurochem
; 126(3): 415-24, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23432034
5.
Alzheimer's Disease and Its Possible Evolutionary Origin: Hypothesis.
Cells
; 12(12)2023 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37371088
6.
Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein.
Biochem Biophys Res Commun
; 424(1): 147-51, 2012 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22732405
7.
Reduction of the immunostainable length of the hippocampal dentate granule cells' primary cilia in 3xAD-transgenic mice producing human Aß(1-42) and tau.
Biochem Biophys Res Commun
; 427(1): 218-22, 2012 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22995307
8.
Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer's disease therapeutic.
J Cereb Blood Flow Metab
; 42(5): 788-801, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34378436
9.
NMR analysis of the correlation of metabolic changes in blood and cerebrospinal fluid in Alzheimer model male and female mice.
PLoS One
; 16(5): e0250568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33970919
10.
The p75 neurotrophin receptor is localized to primary cilia in adult murine hippocampal dentate gyrus granule cells.
Biochem Biophys Res Commun
; 401(3): 458-62, 2010 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20875398
11.
The phosphatase inhibitor, okadaic acid, strongly protects primary rat cortical neurons from lethal oxygen-glucose deprivation.
Biochem Biophys Res Commun
; 378(3): 394-8, 2009 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-19026614
12.
Association of Gap-43 (neuromodulin) with microtubule-associated protein MAP-2 in neuronal cells.
Biochem Biophys Res Commun
; 371(4): 679-83, 2008 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455509
13.
PLA(2) signaling is involved in calpain-mediated degradation of synaptic dihydropyrimidinase-like 3 protein in response to NMDA excitotoxicity.
Neurosci Lett
; 430(3): 197-202, 2008 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-18053648
14.
Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation.
Brain Res
; 1119(1): 40-9, 2006 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-16987501
15.
Relative expression of the p75 neurotrophin receptor, tyrosine receptor kinase A, and insulin receptor in SH-SY5Y neuroblastoma cells and hippocampi from Alzheimer's disease patients.
Neurochem Int
; 101: 22-29, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27693452
16.
The gas7 protein potentiates NGF-mediated differentiation of PC12 cells.
Brain Res
; 1036(1-2): 27-34, 2005 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15725398
17.
Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development.
Brain Res Dev Brain Res
; 160(2): 275-86, 2005 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16271399
18.
The Possible Roles of the Dentate Granule Cell's Leptin and Other Ciliary Receptors in Alzheimer's Neuropathology.
Cells
; 4(3): 253-74, 2015 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26184316
19.
Preventing the spread of Alzheimer's disease neuropathology: a role for calcilytics?
Curr Pharm Biotechnol
; 16(8): 696-706, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25941885
20.
Do astrocytes collaborate with neurons in spreading the "infectious" aß and Tau drivers of Alzheimer's disease?
Neuroscientist
; 21(1): 9-29, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24740577