Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer.

Bowling, Elizabeth A; Wang, Jarey H; Gong, Fade; Wu, William; Neill, Nicholas J; Kim, Ik Sun; Tyagi, Siddhartha; Orellana, Mayra; Kurley, Sarah J; Dominguez-Vidaña, Rocio; Chung, Hsiang-Ching; Hsu, Tiffany Y-T; Dubrulle, Julien; Saltzman, Alexander B; Li, Heyuan; Meena, Jitendra K; Canlas, Gino M; Chamakuri, Srinivas; Singh, Swarnima; Simon, Lukas M; Olson, Calla M; Dobrolecki, Lacey E; Lewis, Michael T; Zhang, Bing; Golding, Ido; Rosen, Jeffrey M; Young, Damian W; Malovannaya, Anna; Stossi, Fabio; Miles, George; Ellis, Matthew J; Yu, Lihua; Buonamici, Silvia; Lin, Charles Y; Karlin, Kristen L; Zhang, Xiang H-F; Westbrook, Thomas F.

Cell ; 184(2): 384-403.e21, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33450205

2.

Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.

Kandel, Prasanna; Semerci, Fatih; Mishra, Rachana; Choi, William; Bajic, Aleksandar; Baluya, Dodge; Ma, LiHua; Chen, Kevin; Cao, Austin C; Phongmekhin, Tipwarin; Matinyan, Nick; Jiménez-Panizo, Alba; Chamakuri, Srinivas; Raji, Idris O; Chang, Lyra; Fuentes-Prior, Pablo; MacKenzie, Kevin R; Benn, Caroline L; Estébanez-Perpiñá, Eva; Venken, Koen; Moore, David D; Young, Damian W; Maletic-Savatic, Mirjana.

Proc Natl Acad Sci U S A ; 119(13): e2023784119, 2022 03 29.

Artigo em Inglês | MEDLINE | ID: mdl-35333654

3.

DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 M^pro inhibitors.

Chamakuri, Srinivas; Lu, Shuo; Ucisik, Melek Nihan; Bohren, Kurt M; Chen, Ying-Chu; Du, Huang-Chi; Faver, John C; Jimmidi, Ravikumar; Li, Feng; Li, Jian-Yuan; Nyshadham, Pranavanand; Palmer, Stephen S; Pollet, Jeroen; Qin, Xuan; Ronca, Shannon E; Sankaran, Banumathi; Sharma, Kiran L; Tan, Zhi; Versteeg, Leroy; Yu, Zhifeng; Matzuk, Martin M; Palzkill, Timothy; Young, Damian W.

Proc Natl Acad Sci U S A ; 118(36)2021 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-34426525

4.

Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles.

Viveki, Amol B; Mansfield, Timothy M; Tran, Kevin A; Lenkeit, Evan; MacKenzie, Kevin R; Young, Damian W; Chamakuri, Srinivas.

Chemistry ; 29(55): e202301888, 2023 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-37462979

5.

A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines.

Chamakuri, Srinivas; Tang, Sunny Ann; Tran, Kevin A; Guduru, Shiva Krishna Reddy; Bolin, Peter K; MacKenzie, Kevin R; Young, Damian W.

Molecules ; 27(11)2022 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-35684357

6.

Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library.

Chamakuri, Srinivas; Chung, Mee-Kyung; Samuel, Errol L G; Tran, Kevin A; Chen, Ying-Chu; Nyshadham, Pranavanand; Santini, Conrad; Matzuk, Martin M; Young, Damian W.

Bioorg Med Chem ; 48: 116387, 2021 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-34571488

7.

Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines.

Chamakuri, Srinivas; Shah, Manuj M; Yang, David C H; Santini, Conrad; Young, Damian W.

Org Biomol Chem ; 18(43): 8844-8849, 2020 11 12.

Artigo em Inglês | MEDLINE | ID: mdl-33118584

8.

Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.

Jain, Prashi; Raji, Idris O; Chamakuri, Srinivas; MacKenzie, Kevin R; Ebright, Brandon T; Santini, Conrad; Young, Damian W.

J Org Chem ; 84(10): 6040-6064, 2019 05 17.

Artigo em Inglês | MEDLINE | ID: mdl-30848904

9.

Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production.

Reddy Guduru, Shiva Krishna; Chamakuri, Srinivas; Raji, Idris O; MacKenzie, Kevin R; Santini, Conrad; Young, Damian W.

J Org Chem ; 83(19): 11777-11793, 2018 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-30180575

10.

Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.

Chamakuri, Srinivas; Jain, Prashi; Reddy Guduru, Shiva Krishna; Arney, J Winston; MacKenzie, Kevin R; Santini, Conrad; Young, Damian W.

J Org Chem ; 83(12): 6541-6555, 2018 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-29751727

11.

Correction to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production.

Chamakuri, Srinivas; Jain, Prashi; Guduru, Shiva Reddy Krishna; Arney, J Winston; MacKenzie, Kevin R; Santini, Conrad; Young, Damian W.

J Org Chem ; 84(7): 4575, 2019 Apr 05.

Artigo em Inglês | MEDLINE | ID: mdl-30855144

12.

Expanding Complex Morpholines Using Systematic Chemical Diversity.

Tang, Sunny Ann; Fults, Afton; Boyd, Shelton R; Gattu, Nikhil; Tran, Kevin A; Fan, Jiayi; MacKenzie, Kevin R; Palzkill, Timothy; Young, Damian W; Chamakuri, Srinivas.

Org Lett ; 26(17): 3493-3497, 2024 May 03.

Artigo em Inglês | MEDLINE | ID: mdl-38506470

13.

Exploiting the Carboxylate-Binding Pocket of ß-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library.

Park, Suhyeorn; Fan, Jiayi; Chamakuri, Srinivas; Palaniappan, Murugesan; Sharma, Kiran; Qin, Xuan; Wang, Jian; Tan, Zhi; Judge, Allison; Hu, Liya; Sankaran, Banumathi; Li, Feng; Prasad, B V Venkataram; Matzuk, Martin M; Palzkill, Timothy.

J Med Chem ; 67(1): 620-642, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-38117688

14.

Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1.

Holmes, Secondra; Jain, Prashi; Rodriguez, Kenneth Guzman; Williams, Jade; Yu, Zhifeng; Cerda-Smith, Christian; Samuel, Errol L G; Campbell, James; Hakenjos, John Michael; Monsivais, Diana; Li, Feng; Chamakuri, Srinivas; Matzuk, Martin M; Santini, Conrad; MacKenzie, Kevin R; Young, Damian W.

ACS Med Chem Lett ; 15(1): 107-115, 2024 Jan 11.

Artigo em Inglês | MEDLINE | ID: mdl-38229743

15.

Reversible male contraception by targeted inhibition of serine/threonine kinase 33.

Ku, Angela F; Sharma, Kiran L; Ta, Hai Minh; Sutton, Courtney M; Bohren, Kurt M; Wang, Yong; Chamakuri, Srinivas; Chen, Ruihong; Hakenjos, John M; Jimmidi, Ravikumar; Kent, Katarzyna; Li, Feng; Li, Jian-Yuan; Ma, Lang; Madasu, Chandrashekhar; Palaniappan, Murugesan; Palmer, Stephen S; Qin, Xuan; Robers, Matthew B; Sankaran, Banumathi; Tan, Zhi; Vasquez, Yasmin M; Wang, Jian; Wilkinson, Jennifer; Yu, Zhifeng; Ye, Qiuji; Young, Damian W; Teng, Mingxing; Kim, Choel; Matzuk, Martin M.

Science ; 384(6698): 885-890, 2024 May 24.

Artigo em Inglês | MEDLINE | ID: mdl-38781365

16.

DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors.

Jimmidi, Ravikumar; Chamakuri, Srinivas; Lu, Shuo; Ucisik, Melek Nihan; Chen, Peng-Jen; Bohren, Kurt M; Moghadasi, Seyed Arad; Versteeg, Leroy; Nnabuife, Christina; Li, Jian-Yuan; Qin, Xuan; Chen, Ying-Chu; Faver, John C; Nyshadham, Pranavanand; Sharma, Kiran L; Sankaran, Banumathi; Judge, Allison; Yu, Zhifeng; Li, Feng; Pollet, Jeroen; Harris, Reuben S; Matzuk, Martin M; Palzkill, Timothy; Young, Damian W.

Commun Chem ; 6(1): 164, 2023 Aug 04.

Artigo em Inglês | MEDLINE | ID: mdl-37542196

17.

Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M^pro/3CL^pro in Living Cells.

Moghadasi, Seyed Arad; Esler, Morgan A; Otsuka, Yuka; Becker, Jordan T; Moraes, Sofia N; Anderson, Constance B; Chamakuri, Srinivas; Belica, Christopher; Wick, Chloe; Harki, Daniel A; Young, Damian W; Scampavia, Louis; Spicer, Timothy P; Shi, Ke; Aihara, Hideki; Brown, William L; Harris, Reuben S.

mBio ; 13(3): e0078422, 2022 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-35471084

18.

Small molecule modulators of protein-protein interactions: selected case studies.

Aeluri, Madhu; Chamakuri, Srinivas; Dasari, Bhanudas; Guduru, Shiva Krishna Reddy; Jimmidi, Ravikumar; Jogula, Srinivas; Arya, Prabhat.

Chem Rev ; 114(9): 4640-94, 2014 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-24673632

19.

Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls.

Monty, Olivier B C; Simmons, Nicholas; Chamakuri, Srinivas; Matzuk, Martin M; Young, Damian W.

ACS Comb Sci ; 22(12): 833-843, 2020 12 14.

Artigo em Inglês | MEDLINE | ID: mdl-33074645

20.

Trisubstituted triumph.

Young, Damian W; Chamakuri, Srinivas.

Nat Chem ; 14(6): 595-597, 2022 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-35668207

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