Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1.

Lee, JuYeon; Bai, Yugang; Chembazhi, Ullas V; Peng, Shaohong; Yum, Kevin; Luu, Long M; Hagler, Lauren D; Serrano, Julio F; Chan, H Y Edwin; Kalsotra, Auinash; Zimmerman, Steven C.

Proc Natl Acad Sci U S A ; 116(18): 8709-8714, 2019 04 30.

Artigo em Inglês | MEDLINE | ID: mdl-30975744

2.

RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2.

Li, Pan P; Moulick, Roumita; Feng, Hongxuan; Sun, Xin; Arbez, Nicolas; Jin, Jing; Marque, Leonard O; Hedglen, Erin; Chan, H Y Edwin; Ross, Christopher A; Pulst, Stefan M; Margolis, Russell L; Woodson, Sarah; Rudnicki, Dobrila D.

Mov Disord ; 36(11): 2519-2529, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34390268

3.

Integrating Display and Delivery Functionality with a Cell Penetrating Peptide Mimic as a Scaffold for Intracellular Multivalent Multitargeting.

Bai, Yugang; Nguyen, Lien; Song, Ziyuan; Peng, Shaohong; Lee, JuYeon; Zheng, Nan; Kapoor, Iti; Hagler, Lauren D; Cai, Kaimin; Cheng, Jianjun; Chan, H Y Edwin; Zimmerman, Steven C.

J Am Chem Soc ; 138(30): 9498-507, 2016 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-27355522

4.

Rationally designed small molecules that target both the DNA and RNA causing myotonic dystrophy type 1.

Nguyen, Lien; Luu, Long M; Peng, Shaohong; Serrano, Julio F; Chan, H Y Edwin; Zimmerman, Steven C.

J Am Chem Soc ; 137(44): 14180-9, 2015 Nov 11.

Artigo em Inglês | MEDLINE | ID: mdl-26473464

5.

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia.

Tsoi, Ho; Yu, Allen C S; Chen, Zhefan S; Ng, Nelson K N; Chan, Anne Y Y; Yuen, Liz Y P; Abrigo, Jill M; Tsang, Suk Ying; Tsui, Stephen K W; Tong, Tony M F; Lo, Ivan F M; Lam, Stephen T S; Mok, Vincent C T; Wong, Lawrence K S; Ngo, Jacky C K; Lau, Kwok-Fai; Chan, Ting-Fung; Chan, H Y Edwin.

J Med Genet ; 51(9): 590-5, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25062847

6.

Targeting toxic RNAs that cause myotonic dystrophy type 1 (DM1) with a bisamidinium inhibitor.

Wong, Chun-Ho; Nguyen, Lien; Peh, Jessie; Luu, Long M; Sanchez, Jeannette S; Richardson, Stacie L; Tuccinardi, Tiziano; Tsoi, Ho; Chan, Wood Yee; Chan, H Y Edwin; Baranger, Anne M; Hergenrother, Paul J; Zimmerman, Steven C.

J Am Chem Soc ; 136(17): 6355-61, 2014 Apr 30.

Artigo em Inglês | MEDLINE | ID: mdl-24702247

7.

Crystallization and preliminary crystallographic analysis of the central domain of Drosophila Dribble, a protein that is essential for ribosome biogenesis.

Cheng, Tat Cheung; Chen, Yu Wai; Wong, Kam Bo; Ngai, Sai-Ming; Chan, H Y Edwin.

Acta Crystallogr Sect F Struct Biol Cryst Commun ; 66(Pt 5): 546-8, 2010 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-20445256

8.

Exclusion of unsuitable CNS drug candidates based on their physicochemical properties and unbound fractions in biomatrices for brain microdialysis investigations.

Wang, Qianwen; Ren, Tianjing; Zhao, Jiajia; Wong, Chun-Ho; Chan, H Y Edwin; Zuo, Zhong.

J Pharm Biomed Anal ; 178: 112946, 2020 Jan 30.

Artigo em Inglês | MEDLINE | ID: mdl-31727358

9.

A Three-Way Combinatorial CRISPR Screen for Analyzing Interactions among Druggable Targets.

Zhou, Peng; Chan, Becky K C; Wan, Yuk Kei; Yuen, Chaya T L; Choi, Gigi C G; Li, Xinran; Tong, Cindy S W; Zhong, Sophia S W; Sun, Jieran; Bao, Yufan; Mak, Silvia Y L; Chow, Maggie Z Y; Khaw, Jien Vei; Leung, Suet Yi; Zheng, Zongli; Cheung, Lydia W T; Tan, Kaeling; Wong, Koon Ho; Chan, H Y Edwin; Wong, Alan S L.

Cell Rep ; 32(6): 108020, 2020 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-32783942

10.

A mannose/glucose-specific lectin from Chinese evergreen chinkapin (Castanopsis chinensis).

Wong, Jack H; Chan, H Y Edwin; Ng, T B.

Biochim Biophys Acta ; 1780(9): 1017-22, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18570898

11.

The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

Lee, Francesca K M; Wong, Azaria K Y; Lee, Yuk Wa; Wan, Oi Wan; Chan, H Y Edwin; Chung, Kenny K K.

J Neurochem ; 110(1): 208-19, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19457126

12.

Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration.

Wong, S L Alan; Chan, Wing Man; Chan, H Y Edwin.

FASEB J ; 22(9): 3348-57, 2008 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-18559990

13.

Efficient brain uptake and distribution of an expanded CAG RNA inhibitor DB213 via intranasal administration.

Wang, Qianwen; Peng, Shaohong; Hu, Yue; Wong, Chun-Ho; Kwan, Kin Ming; Chan, H Y Edwin; Zuo, Zhong.

Eur J Pharm Sci ; 127: 240-251, 2019 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-30391403

14.

Maternal oxytocin responsiveness improves specificity of positive social memory recall.

Tse, Wai S; Siu, Angela F Y; Zhang, Qian; Chan, H Y Edwin.

Psychoneuroendocrinology ; 98: 148-152, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30149269

15.

Statistical Design of Experiment (DoE) based development and optimization of DB213 in situ thermosensitive gel for intranasal delivery.

Wang, Qianwen; Wong, Chun-Ho; Chan, H Y Edwin; Lee, Wai-Yip; Zuo, Zhong.

Int J Pharm ; 539(1-2): 50-57, 2018 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-29366939

16.

Pharmacokinetics and brain uptake of HIV-1 replication inhibitor DB213 in Sprague-Dawley rats.

Wang, Qianwen; Zhang, Yufeng; Qian, Shuai; Peng, Shaohong; Zhang, Qian; Wong, Chun-Ho; Chan, H Y Edwin; Zuo, Zhong.

J Pharm Biomed Anal ; 125: 41-7, 2016 Jun 05.

Artigo em Inglês | MEDLINE | ID: mdl-26999321

17.

A Potent Inhibitor of Protein Sequestration by Expanded Triplet (CUG) Repeats that Shows Phenotypic Improvements in a Drosophila Model of Myotonic Dystrophy.

Luu, Long M; Nguyen, Lien; Peng, Shaohong; Lee, JuYeon; Lee, Hyang Yeon; Wong, Chun-Ho; Hergenrother, Paul J; Chan, H Y Edwin; Zimmerman, Steven C.

ChemMedChem ; 11(13): 1428-35, 2016 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-27245480

18.

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

Lu, Jia-Hong; Tan, Jie-Qiong; Durairajan, Siva Sundara Kumar; Liu, Liang-Feng; Zhang, Zhuo-Hua; Ma, Long; Shen, Han-Ming; Chan, H Y Edwin; Li, Min.

Autophagy ; 8(1): 98-108, 2012 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-22113202

19.

Fly-ing from genes to drugs.

Chan, H Y Edwin.

Trends Mol Med ; 8(3): 99-101, 2002 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-11879764

20.

Drosophila models of polyglutamine diseases.

Chan, H Y Edwin; Bonini, Nancy M.

Methods Mol Biol ; 217: 241-51, 2003.

Artigo em Inglês | MEDLINE | ID: mdl-12491937

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