Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Xist ribonucleoproteins promote female sex-biased autoimmunity.

Dou, Diana R; Zhao, Yanding; Belk, Julia A; Zhao, Yang; Casey, Kerriann M; Chen, Derek C; Li, Rui; Yu, Bingfei; Srinivasan, Suhas; Abe, Brian T; Kraft, Katerina; Hellström, Ceke; Sjöberg, Ronald; Chang, Sarah; Feng, Allan; Goldman, Daniel W; Shah, Ami A; Petri, Michelle; Chung, Lorinda S; Fiorentino, David F; Lundberg, Emma K; Wutz, Anton; Utz, Paul J; Chang, Howard Y.

Cell ; 187(3): 733-749.e16, 2024 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-38306984

2.

Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells.

Tsuchida, Connor A; Brandes, Nadav; Bueno, Raymund; Trinidad, Marena; Mazumder, Thomas; Yu, Bingfei; Hwang, Byungjin; Chang, Christopher; Liu, Jamin; Sun, Yang; Hopkins, Caitlin R; Parker, Kevin R; Qi, Yanyan; Hofman, Laura; Satpathy, Ansuman T; Stadtmauer, Edward A; Cate, Jamie H D; Eyquem, Justin; Fraietta, Joseph A; June, Carl H; Chang, Howard Y; Ye, Chun Jimmie; Doudna, Jennifer A.

Cell ; 186(21): 4567-4582.e20, 2023 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-37794590

3.

Engineered cell entry links receptor biology with single-cell genomics.

Yu, Bingfei; Shi, Quanming; Belk, Julia A; Yost, Kathryn E; Parker, Kevin R; Li, Rui; Liu, Betty B; Huang, Huang; Lingwood, Daniel; Greenleaf, William J; Davis, Mark M; Satpathy, Ansuman T; Chang, Howard Y.

Cell ; 185(26): 4904-4920.e22, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36516854

4.

Enhanced safety and efficacy of protease-regulated CAR-T cell receptors.

Labanieh, Louai; Majzner, Robbie G; Klysz, Dorota; Sotillo, Elena; Fisher, Chris J; Vilches-Moure, José G; Pacheco, Kaithlen Zen B; Malipatlolla, Meena; Xu, Peng; Hui, Jessica H; Murty, Tara; Theruvath, Johanna; Mehta, Nishant; Yamada-Hunter, Sean A; Weber, Evan W; Heitzeneder, Sabine; Parker, Kevin R; Satpathy, Ansuman T; Chang, Howard Y; Lin, Michael Z; Cochran, Jennifer R; Mackall, Crystal L.

Cell ; 185(10): 1745-1763.e22, 2022 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-35483375

5.

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.

Yu, Bingfei; Qi, Yanyan; Li, Rui; Shi, Quanming; Satpathy, Ansuman T; Chang, Howard Y.

Cell ; 184(7): 1790-1803.e17, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33735607

6.

Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution.

Trevino, Alexandro E; Müller, Fabian; Andersen, Jimena; Sundaram, Laksshman; Kathiria, Arwa; Shcherbina, Anna; Farh, Kyle; Chang, Howard Y; PaÈca, Anca M; Kundaje, Anshul; PaÈca, Sergiu P; Greenleaf, William J.

Cell ; 184(19): 5053-5069.e23, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34390642

7.

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.

Flynn, Ryan A; Belk, Julia A; Qi, Yanyan; Yasumoto, Yuki; Wei, Jin; Alfajaro, Mia Madel; Shi, Quanming; Mumbach, Maxwell R; Limaye, Aditi; DeWeirdt, Peter C; Schmitz, Cameron O; Parker, Kevin R; Woo, Elizabeth; Chang, Howard Y; Horvath, Tamas L; Carette, Jan E; Bertozzi, Carolyn R; Wilen, Craig B; Satpathy, Ansuman T.

Cell ; 184(9): 2394-2411.e16, 2021 04 29.

Artigo em Inglês | MEDLINE | ID: mdl-33743211

8.

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.

Nuñez, James K; Chen, Jin; Pommier, Greg C; Cogan, J Zachery; Replogle, Joseph M; Adriaens, Carmen; Ramadoss, Gokul N; Shi, Quanming; Hung, King L; Samelson, Avi J; Pogson, Angela N; Kim, James Y S; Chung, Amanda; Leonetti, Manuel D; Chang, Howard Y; Kampmann, Martin; Bernstein, Bradley E; Hovestadt, Volker; Gilbert, Luke A; Weissman, Jonathan S.

Cell ; 184(9): 2503-2519.e17, 2021 04 29.

Artigo em Inglês | MEDLINE | ID: mdl-33838111

9.

Long Noncoding RNAs: Molecular Modalities to Organismal Functions.

Rinn, John L; Chang, Howard Y.

Annu Rev Biochem ; 89: 283-308, 2020 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-32569523

10.

Long non-coding RNAs: definitions, functions, challenges and recommendations.

Mattick, John S; Amaral, Paulo P; Carninci, Piero; Carpenter, Susan; Chang, Howard Y; Chen, Ling-Ling; Chen, Runsheng; Dean, Caroline; Dinger, Marcel E; Fitzgerald, Katherine A; Gingeras, Thomas R; Guttman, Mitchell; Hirose, Tetsuro; Huarte, Maite; Johnson, Rory; Kanduri, Chandrasekhar; Kapranov, Philipp; Lawrence, Jeanne B; Lee, Jeannie T; Mendell, Joshua T; Mercer, Timothy R; Moore, Kathryn J; Nakagawa, Shinichi; Rinn, John L; Spector, David L; Ulitsky, Igor; Wan, Yue; Wilusz, Jeremy E; Wu, Mian.

Nat Rev Mol Cell Biol ; 24(6): 430-447, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-36596869

11.

Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies.

Parker, Kevin R; Migliorini, Denis; Perkey, Eric; Yost, Kathryn E; Bhaduri, Aparna; Bagga, Puneet; Haris, Mohammad; Wilson, Neil E; Liu, Fang; Gabunia, Khatuna; Scholler, John; Montine, Thomas J; Bhoj, Vijay G; Reddy, Ravinder; Mohan, Suyash; Maillard, Ivan; Kriegstein, Arnold R; June, Carl H; Chang, Howard Y; Posey, Avery D; Satpathy, Ansuman T.

Cell ; 183(1): 126-142.e17, 2020 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-32961131

12.

Divergent clonal differentiation trajectories of T cell exhaustion.

Daniel, Bence; Yost, Kathryn E; Hsiung, Sunnie; Sandor, Katalin; Xia, Yu; Qi, Yanyan; Hiam-Galvez, Kamir J; Black, Mollie; J Raposo, Colin; Shi, Quanming; Meier, Stefanie L; Belk, Julia A; Giles, Josephine R; Wherry, E John; Chang, Howard Y; Egawa, Takeshi; Satpathy, Ansuman T.

Nat Immunol ; 23(11): 1614-1627, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36289450

13.

Atlas of Subcellular RNA Localization Revealed by APEX-Seq.

Fazal, Furqan M; Han, Shuo; Parker, Kevin R; Kaewsapsak, Pornchai; Xu, Jin; Boettiger, Alistair N; Chang, Howard Y; Ting, Alice Y.

Cell ; 178(2): 473-490.e26, 2019 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-31230715

14.

Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.

Rubin, Adam J; Parker, Kevin R; Satpathy, Ansuman T; Qi, Yanyan; Wu, Beijing; Ong, Alvin J; Mumbach, Maxwell R; Ji, Andrew L; Kim, Daniel S; Cho, Seung Woo; Zarnegar, Brian J; Greenleaf, William J; Chang, Howard Y; Khavari, Paul A.

Cell ; 176(1-2): 361-376.e17, 2019 01 10.

Artigo em Inglês | MEDLINE | ID: mdl-30580963

15.

Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation.

Buenrostro, Jason D; Corces, M Ryan; Lareau, Caleb A; Wu, Beijing; Schep, Alicia N; Aryee, Martin J; Majeti, Ravindra; Chang, Howard Y; Greenleaf, William J.

Cell ; 173(6): 1535-1548.e16, 2018 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-29706549

16.

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1.

Chen, Lu; Roake, Caitlin M; Freund, Adam; Batista, Pedro J; Tian, Siqi; Yin, Yi A; Gajera, Chandresh R; Lin, Shengda; Lee, Byron; Pech, Matthew F; Venteicher, Andrew S; Das, Rhiju; Chang, Howard Y; Artandi, Steven E.

Cell ; 174(1): 218-230.e13, 2018 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-29804836

17.

Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.

Cho, Seung Woo; Xu, Jin; Sun, Ruping; Mumbach, Maxwell R; Carter, Ava C; Chen, Y Grace; Yost, Kathryn E; Kim, Jeewon; He, Jing; Nevins, Stephanie A; Chin, Suet-Feung; Caldas, Carlos; Liu, S John; Horlbeck, Max A; Lim, Daniel A; Weissman, Jonathan S; Curtis, Christina; Chang, Howard Y.

Cell ; 173(6): 1398-1412.e22, 2018 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-29731168

18.

Identification of the Human Skeletal Stem Cell.

Chan, Charles K F; Gulati, Gunsagar S; Sinha, Rahul; Tompkins, Justin Vincent; Lopez, Michael; Carter, Ava C; Ransom, Ryan C; Reinisch, Andreas; Wearda, Taylor; Murphy, Matthew; Brewer, Rachel E; Koepke, Lauren S; Marecic, Owen; Manjunath, Anoop; Seo, Eun Young; Leavitt, Tripp; Lu, Wan-Jin; Nguyen, Allison; Conley, Stephanie D; Salhotra, Ankit; Ambrosi, Thomas H; Borrelli, Mimi R; Siebel, Taylor; Chan, Karen; Schallmoser, Katharina; Seita, Jun; Sahoo, Debashis; Goodnough, Henry; Bishop, Julius; Gardner, Michael; Majeti, Ravindra; Wan, Derrick C; Goodman, Stuart; Weissman, Irving L; Chang, Howard Y; Longaker, Michael T.

Cell ; 175(1): 43-56.e21, 2018 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-30241615

19.

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.

Vardhana, Santosha A; Hwee, Madeline A; Berisa, Mirela; Wells, Daniel K; Yost, Kathryn E; King, Bryan; Smith, Melody; Herrera, Pamela S; Chang, Howard Y; Satpathy, Ansuman T; van den Brink, Marcel R M; Cross, Justin R; Thompson, Craig B.

Nat Immunol ; 21(9): 1022-1033, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32661364

20.

IL-4Rα Inhibitor for Atopic Disease.

Chang, Howard Y; Nadeau, Kari C.

Cell ; 170(2): 222, 2017 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-28708993

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