Detalhe da pesquisa
1.
Lack of antiviral activity of probenecid in vitro and in Syrian golden hamsters.
J Antimicrob Chemother
; 79(1): 172-178, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37995258
2.
The translational challenge in Chagas disease drug development.
Mem Inst Oswaldo Cruz
; 117: e200501, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35613156
3.
A Multi-Species Phenotypic Screening Assay for Leishmaniasis Drug Discovery Shows That Active Compounds Display a High Degree of Species-Specificity.
Molecules
; 25(11)2020 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32486239
4.
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Bioorg Med Chem Lett
; 28(2): 207-213, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191556
5.
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Bioorg Med Chem Lett
; 27(11): 2583-2589, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462832
6.
Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.
Bioorg Med Chem
; 24(7): 1573-81, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26935942
7.
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
Antimicrob Agents Chemother
; 59(8): 4653-61, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26014936
8.
Enantiomers of nifurtimox do not exhibit stereoselective anti-Trypanosoma cruzi activity, toxicity, or pharmacokinetic properties.
Antimicrob Agents Chemother
; 59(6): 3645-7, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25845874
9.
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Bioorg Med Chem
; 23(19): 6467-76, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26344593
10.
Complexes of Trypanosoma cruzi sterol 14α-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: structural basis for pathogen selectivity.
J Biol Chem
; 288(44): 31602-15, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24047900
11.
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Antimicrob Agents Chemother
; 58(8): 4362-70, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841257
12.
Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment.
BMC Infect Dis
; 14: 302, 2014 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24894358
13.
In Vivo Bioluminescence Imaging Reveals Differences in Leishmania infantum Parasite Killing Kinetics by Antileishmanial Reference Drugs.
ACS Infect Dis
; 2024 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38733389
14.
Further preclinical characterization of molnupiravir against SARS-CoV-2: Antiviral activity determinants and viral genome alteration patterns.
Heliyon
; 10(10): e30862, 2024 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38803975
15.
Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.
iScience
; 27(3): 109049, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38361624
16.
Generation and evaluation of protease inhibitor-resistant SARS-CoV-2 strains.
Antiviral Res
; 222: 105814, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38272321
17.
Serological and parasitological response in chronic Chagas patients 3 years after nifurtimox treatment.
BMC Infect Dis
; 13: 85, 2013 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23406191
18.
Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3-benzothiazoles as antichagasic agents.
Bioorg Med Chem
; 21(21): 6600-7, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012457
19.
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Bioorg Med Chem
; 21(7): 1756-63, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23462713
20.
State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation.
Res Rep Trop Med
; 14: 1-19, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37337597