Detalhe da pesquisa
1.
Novel KV7 ion channel openers for the treatment of epilepsy and implications for detrusor tissue contraction.
Bioorg Med Chem Lett
; 28(23-24): 3793-3797, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30327146
2.
CardioMotion: identification of functional and structural cardiotoxic liabilities in small molecules through brightfield kinetic imaging.
Toxicol Sci
; 195(1): 61-70, 2023 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462734
3.
Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications.
Clin Transl Sci
; 15(8): 1978-1989, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35579204
4.
Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off-label in the first wave of COVID-19.
Clin Transl Sci
; 14(3): 1133-1146, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620150
5.
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective.
Clin Pharmacol Ther
; 109(2): 310-318, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32866317
6.
Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Sci Rep
; 10(1): 11884, 2020 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32665705
7.
Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
Sci Rep
; 10(1): 5627, 2020 03 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32221320
8.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551024
9.
Engineered Cardiac Tissues Generated in the Biowire II: A Platform for Human-Based Drug Discovery.
Toxicol Sci
; 172(1): 89-97, 2019 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31385592
10.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Front Pharmacol
; 10: 884, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31447679
11.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Front Pharmacol
; 10: 934, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31555128
12.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344914
13.
Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.
Assay Drug Dev Technol
; 4(1): 73-82, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16506891
14.
Embryonic stem cells in predictive cardiotoxicity: laser capture microscopy enables assay development.
Toxicol Sci
; 90(1): 149-58, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16357009
15.
Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging.
J Pharmacol Toxicol Methods
; 81: 240-50, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27184445
16.
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.
J Biomol Screen
; 21(1): 1-11, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26170255
17.
Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart.
J Am Coll Cardiol
; 44(4): 837-45, 2004 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15312868
18.
Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium.
J Mol Cell Cardiol
; 36(1): 33-42, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14734045