Detalhe da pesquisa
1.
Specific Forms of Graphene Quantum Dots Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells.
Int J Mol Sci
; 24(4)2023 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835458
2.
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
Bioorg Chem
; 95: 103135, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31923631
3.
Novel variant Pro143Ala in HTRA2 contributes to Parkinson's disease by inducing hyperphosphorylation of HTRA2 protein in mitochondria.
Hum Genet
; 130(6): 817-27, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21701785
4.
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Bioorg Med Chem
; 19(21): 6316-28, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21958737
5.
Synthesis and structure-activity relationship of 6-arylureido-3-pyrrol-2-ylmethylideneindolin-2-one derivatives as potent receptor tyrosine kinase inhibitors.
Bioorg Med Chem
; 18(13): 4674-86, 2010 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20570526
6.
Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.
ACS Med Chem Lett
; 10(1): 22-26, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655941
7.
A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.
Neuropharmacology
; 92: 146-57, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25596491
8.
Nucleosides. IX. Synthesis of purine N(3),5'-cyclonucleosides and N(3),5'-cyclo-2',3'-seconucleosides via Mitsunobu reaction as TIBO-like derivatives.
Nucleosides Nucleotides Nucleic Acids
; 23(1-2): 347-59, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15043159
9.
Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor.
Eur J Med Chem
; 84: 312-34, 2014 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25036791
10.
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Eur J Med Chem
; 85: 268-88, 2014 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25089810
11.
Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors.
ChemMedChem
; 7(5): 850-60, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22383290
12.
Anticancer activity of a cyclooxygenase inhibitor, CX9051, in human prostate cancer cells: the roles of NF-kappaB and crosstalk between the extrinsic and intrinsic apoptotic pathways.
Naunyn Schmiedebergs Arch Pharmacol
; 382(2): 159-69, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20532752
13.
Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase.
J Med Chem
; 52(9): 2716-23, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19419203
14.
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
Bioorg Med Chem Lett
; 17(6): 1769-72, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17239588
15.
Nonreductive deiodination of ortho-iodo-hydroxylated arenes using tertiary amines.
J Org Chem
; 70(21): 8590-3, 2005 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-16209616
16.
Synthesis of anti-microtubule N-(2-Arylindol-7-yl)benzenesulfonamide derivatives and their antitumor mechanisms.
ChemMedChem
; 5(9): 1489-97, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20672297
17.
Studies on quinazolines. 11. Intramolecular imidate-amide rearrangement of 2-substituted 4-(omega-chloroalkoxy)quinazoline derivatives. 1,3 -O --> N shift of chloroalkyl groups via cyclic 1,3-azaoxonium intermediates.
J Org Chem
; 68(6): 2502-5, 2003 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12636427