1.
Org Biomol Chem
; 21(46): 9236-9241, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37966029
RESUMO
We herein propose a HFIP-promoted tandem cyclization reaction for the synthesis of difluoro/trifluoromethyl carbinol-containing chromones from o-hydroxyphenyl enaminones at room temperature. This protocol provides a facile and efficient approach to access diverse difluoro/trifluoromethylated carbinols in good to excellent yields. In addition, gram-scale and synthetic derivatization experiments have also been performed.