Detalhe da pesquisa
1.
AI can help to tailor drugs for Africa - but Africans should lead the way.
Nature
; 628(8007): 265-267, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38594395
2.
Integrating Pharmacokinetic-Pharmacodynamic Modeling and Physiologically Based Pharmacokinetic Modeling to Optimize Human Dose Predictions for Plasmodium falciparum Malaria: a Chloroquine Case Study.
Antimicrob Agents Chemother
; 67(5): e0134522, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37010410
3.
Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 65(5)2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33619062
4.
Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones.
Antimicrob Agents Chemother
; 66(4): e0219221, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35266826
5.
Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB.
PLoS Pathog
; 16(6): e1008567, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32574211
6.
Strategies to Combat Multi-Drug Resistance in Tuberculosis.
Acc Chem Res
; 54(10): 2361-2376, 2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33886255
7.
Correction: Antiviral drug discovery: preparing for the next pandemic.
Chem Soc Rev
; 50(16): 9346, 2021 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34346445
8.
Antiviral drug discovery: preparing for the next pandemic.
Chem Soc Rev
; 50(6): 3647-3655, 2021 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524090
9.
Antimalarial Activities of (Z)-2-(Nitroheteroarylmethylene)-3(2H)-Benzofuranone Derivatives: In Vitro and In Vivo Assessment and ß-Hematin Formation Inhibition Activity.
Antimicrob Agents Chemother
; 65(9): e0268320, 2021 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34228544
10.
Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932368
11.
Intrinsic fluorescence properties of antimalarial pyrido[1,2-a]benzimidazoles facilitate subcellular accumulation and mechanistic studies in the human malaria parasite Plasmodium falciparum.
Org Biomol Chem
; 18(42): 8668-8676, 2020 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33078179
12.
Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds.
Bioorg Med Chem
; 28(9): 115442, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32209295
13.
Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity.
Bioorg Med Chem
; 28(13): 115530, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32362386
14.
Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid-pyrimidine conjugates.
Mol Divers
; 24(4): 949-955, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31691051
15.
Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles.
Molecules
; 25(24)2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33333924
16.
Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Antimicrob Agents Chemother
; 62(12)2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30249687
17.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
18.
Potent Plasmodium falciparum gametocytocidal compounds identified by exploring the kinase inhibitor chemical space for dual active antimalarials.
J Antimicrob Chemother
; 73(5): 1279-1290, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29420756
19.
Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery.
Acc Chem Res
; 50(7): 1606-1616, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28636311
20.
Synthesis and biological evaluation of aryl-oxadiazoles as inhibitors of Mycobacterium tuberculosis.
Bioorg Med Chem Lett
; 28(10): 1758-1764, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29680666