Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.

Rojas, Tomas; Cheng, Weiwei; Gao, Zhe; Liu, Xiaoqi; Wang, Yakun; Malla, Adarsha P; Chin, Alfred C; Romer, Lewis H; Snyder, Solomon H; Fu, Chenglai.

Proc Natl Acad Sci U S A ; 116(8): 3278-3287, 2019 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-30718399

2.

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Fu, Chenglai; Tyagi, Richa; Chin, Alfred C; Rojas, Tomas; Li, Ruo-Jing; Guha, Prasun; Bernstein, Isaac A; Rao, Feng; Xu, Risheng; Cha, Jiyoung Y; Xu, Jing; Snowman, Adele M; Semenza, Gregg L; Snyder, Solomon H.

Circ Res ; 122(3): 457-472, 2018 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-29279301

3.

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Fu, Chenglai; Xu, Jing; Cheng, Weiwei; Rojas, Tomas; Chin, Alfred C; Snowman, Adele M; Harraz, Maged M; Snyder, Solomon H.

Proc Natl Acad Sci U S A ; 114(8): 2036-2041, 2017 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-28154132

4.

Neuroinflammation and the cGAS-STING pathway.

Chin, Alfred C.

J Neurophysiol ; 121(4): 1087-1091, 2019 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-30673358

5.

PERK-STING Signaling Drives Neuroinflammation in Traumatic Brain Injury.

Chin, Alfred C.

J Neurosci ; 40(12): 2384-2386, 2020 03 18.

Artigo em Inglês | MEDLINE | ID: mdl-32188742

6.

Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability.

Jin, Hongfu; Liu, Aili; Chin, Alfred C; Fu, Chenglai; Shen, Hui; Cheng, Weiwei.

Mol Brain ; 17(1): 8, 2024 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-38350944

7.

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin.

Fu, Lin; Du, Jimin; Furkert, David; Shipton, Megan L; Liu, Xiaoqi; Aguirre, Tim; Chin, Alfred C; Riley, Andrew M; Potter, Barry V L; Fiedler, Dorothea; Zhang, Xu; Zhu, Yi; Fu, Chenglai.

Cardiovasc Res ; 2024 Jan 22.

Artigo em Inglês | MEDLINE | ID: mdl-38252884

8.

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling.

Qi, Ji; Cheng, Weiwei; Gao, Zhe; Chen, Yuanyuan; Shipton, Megan L; Furkert, David; Chin, Alfred C; Riley, Andrew M; Fiedler, Dorothea; Potter, Barry V L; Fu, Chenglai.

Biomed Pharmacother ; 161: 114449, 2023 May.

Artigo em Inglês | MEDLINE | ID: mdl-36857911

9.

Structural biology and thermodynamics of GluD receptors.

Chin, Alfred C; Lau, Albert Y.

Neuropharmacology ; 191: 108542, 2021 06 15.

Artigo em Inglês | MEDLINE | ID: mdl-33845075

10.

D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2.

Chin, Alfred C; Yovanno, Remy A; Wied, Tyler J; Gershman, Ariel; Lau, Albert Y.

Structure ; 28(10): 1168-1178.e2, 2020 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-32735769

11.

The inositol pyrophosphate 5-InsP₇ drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α.

Chin, Alfred C; Gao, Zhe; Riley, Andrew M; Furkert, David; Wittwer, Christopher; Dutta, Amit; Rojas, Tomas; Semenza, Evan R; Felder, Robin A; Pluznick, Jennifer L; Jessen, Henning J; Fiedler, Dorothea; Potter, Barry V L; Snyder, Solomon H; Fu, Chenglai.

Sci Adv ; 6(44)2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33115740

12.

Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study.

Paranjpe, Manish D; Chin, Alfred C; Paranjpe, Ishan; Reid, Nicholas J; Duy, Phan Q; Wang, Jason K; O'Hagan, Ross; Arzani, Artine; Haghdel, Arsalan; Lim, Clarence C; Orhurhu, Vwaire; Urits, Ivan; Ngo, Anh L; Glicksberg, Benjamin S; Hall, Kathryn T; Mehta, Darshan; Cooper, Richard S; Nadkarni, Girish N.

BMJ Open ; 10(11): e039119, 2020 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-33148746

13.

High Conformational Variability in the GluK2 Kainate Receptor Ligand-Binding Domain.

Wied, Tyler J; Chin, Alfred C; Lau, Albert Y.

Structure ; 27(1): 189-195.e2, 2019 01 02.

Artigo em Inglês | MEDLINE | ID: mdl-30482727

14.

Methotrexate for gestational choriocarcinoma: a paradigm shift in oncology.

Chin, Alfred C.

Nat Rev Endocrinol ; 19(9): 501, 2023 09.

Artigo em Inglês | MEDLINE | ID: mdl-37468700

15.

Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.

Fu, Chenglai; Rojas, Tomas; Chin, Alfred C; Cheng, Weiwei; Bernstein, Isaac A; Albacarys, Lauren K; Wright, William W; Snyder, Solomon H.

Sci Rep ; 8(1): 7039, 2018 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-29728588

16.

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.

Dickens, Alex M; Yoo, Seung Wan; Chin, Alfred C; Xu, Jiadi; Johnson, Tory P; Trout, Amanda L; Hauser, Kurt F; Haughey, Norman J.

Sci Rep ; 7(1): 7748, 2017 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-28798382

17.

Theoretical realities.

Chin, Alfred C.

Nat Rev Chem ; 4(5): 225, 2020 May.

Artigo em Inglês | MEDLINE | ID: mdl-37127987

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Inositol hexakisphosphate kinase 3 promotes focal adhesion turnover via interactions with dynein intermediate chain 2.

Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Neuroinflammation and the cGAS-STING pathway.

PERK-STING Signaling Drives Neuroinflammation in Traumatic Brain Injury.

Deleting IP6K1 stabilizes neuronal sodium-potassium pumps and suppresses excitability.

Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischemia-reperfusion injury by elevating plasma adiponectin.

Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling.

Structural biology and thermodynamics of GluD receptors.

D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2.

The inositol pyrophosphate 5-InsP₇ drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α.

Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study.

High Conformational Variability in the GluK2 Kainate Receptor Ligand-Binding Domain.

Methotrexate for gestational choriocarcinoma: a paradigm shift in oncology.

Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1.

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.

Theoretical realities.