Detalhe da pesquisa
1.
An in vitro toolbox to accelerate anti-malarial drug discovery and development.
Malar J
; 19(1): 1, 2020 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31898492
2.
Potential Diagnostic Imaging of Alzheimer's Disease with Copper-64 Complexes That Bind to Amyloid-ß Plaques.
Inorg Chem
; 58(5): 3382-3395, 2019 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30785268
3.
Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds.
Pharm Res
; 35(11): 210, 2018 Sep 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30225649
4.
Evidence for the in vitro bioactivation of aminopyrazole derivatives: trapping reactive aminopyrazole intermediates using glutathione ethyl ester in human liver microsomes.
Chem Res Toxicol
; 28(9): 1747-52, 2015 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26317231
5.
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
Proc Natl Acad Sci U S A
; 108(11): 4400-5, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300861
6.
Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12).
ACS Omega
; 7(14): 12401-12411, 2022 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35449901
7.
CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity.
Nucleic Acids Res
; 37(19): 6355-70, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19720735
8.
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.
ACS Infect Dis
; 7(7): 1885-1893, 2021 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34101429
9.
Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
J Med Chem
; 64(17): 12582-12602, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34437804
10.
The comparative antimalarial properties of weak base and neutral synthetic ozonides.
Bioorg Med Chem Lett
; 20(2): 563-6, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19962893
11.
Identification of an antimalarial synthetic trioxolane drug development candidate.
Nature
; 430(7002): 900-4, 2004 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15318224
12.
Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.
J Med Chem
; 63(7): 3723-3736, 2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32134263
13.
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
J Med Chem
; 63(9): 4929-4956, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32248693
14.
Stability of peroxide antimalarials in the presence of human hemoglobin.
Antimicrob Agents Chemother
; 53(8): 3496-500, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19487440
15.
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
J Med Chem
; 62(5): 2485-2498, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30715882
16.
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
Bioorg Med Chem Lett
; 18(5): 1555-8, 2008 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18262417
17.
Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.
J Pharm Sci
; 96(11): 2945-56, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17549767
18.
Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439).
J Med Chem
; 60(7): 2654-2668, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28052200
19.
Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
; 830(2): 314-21, 2006 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-16310420
20.
Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin.
J Pharm Sci
; 95(2): 256-67, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16374851