Detalhe da pesquisa
1.
Combination Therapy with Gallium Protoporphyrin and Gallium Nitrate Exhibits Enhanced Antimicrobial Activity In Vitro and In Vivo against Methicillin-Resistant Staphylococcus aureus.
Mol Pharm
; 20(8): 4058-4070, 2023 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37471668
2.
Synthesis and in vitro analysis of novel gallium tetrakis(4-methoxyphenyl)porphyrin and its long-acting nanoparticle as a potent antimycobacterial agent.
Bioorg Med Chem Lett
; 62: 128645, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219822
3.
Synthesis, optimization, in vitro and in vivo study of bicyclic substituted amine as MenA inhibitor.
Bioorg Med Chem Lett
; 47: 128203, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34139327
4.
Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor.
Biol Pharm Bull
; 44(9): 1230-1238, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34471051
5.
Iron/Heme Metabolism-Targeted Gallium(III) Nanoparticles Are Active against Extracellular and Intracellular Pseudomonas aeruginosa and Acinetobacter baumannii.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30782994
6.
Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors.
Antimicrob Agents Chemother
; 63(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962346
7.
In Vitro Efficacy of Free and Nanoparticle Formulations of Gallium(III) meso-Tetraphenylporphyrine against Mycobacterium avium and Mycobacterium abscessus and Gallium Biodistribution in Mice.
Mol Pharm
; 15(3): 1215-1225, 2018 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29421865
8.
Ga(III) Nanoparticles Inhibit Growth of both Mycobacterium tuberculosis and HIV and Release of Interleukin-6 (IL-6) and IL-8 in Coinfected Macrophages.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28167548
9.
Development of potential broad spectrum antimicrobials using C2-symmetric 9-fluorenone alkyl amine.
Bioorg Med Chem Lett
; 26(8): 1997-9, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965856
10.
Regio- and chemoselective immobilization of proteins on gold surfaces.
Bioconjug Chem
; 25(2): 269-75, 2014 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24437976
11.
δ-Deuterium isotope effects as probes for transition-state structures of isoprenoid substrates.
J Org Chem
; 79(8): 3572-80, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24665882
12.
Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.
Bioorg Med Chem
; 21(1): 348-58, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23182215
13.
In Vitro and In Vivo Antimicrobial Activity of an Oxidative Stress-Mediated Bicyclic Menaquinone Biosynthesis Inhibitor against MRSA.
ACS Infect Dis
; 9(10): 2016-2024, 2023 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37655755
14.
Investigating Novel IspE Inhibitors of the MEP Pathway in Mycobacterium.
Microorganisms
; 12(1)2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38276186
15.
Development of Gallium(III) as an Antimicrobial Drug Targeting Pathophysiologic Iron Metabolism of Human Pathogens.
ACS Infect Dis
; 9(4): 716-738, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36995299
16.
Combining Gallium Protoporphyrin and Gallium Nitrate Enhances In Vitro and In Vivo Efficacy against Pseudomonas aeruginosa: Role of Inhibition of Bacterial Antioxidant Enzymes and Resultant Increase in Cytotoxic Reactive Oxygen Species.
ACS Infect Dis
; 8(10): 2096-2105, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36049087
17.
Nanoparticulate ß-Cyclodextrin with Gallium Tetraphenylporphyrin Demonstrates in Vitro and in Vivo Antimicrobial Efficacy against Mycobacteroides abscessus and Mycobacterium avium.
ACS Infect Dis
; 7(8): 2299-2309, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314150
18.
Neural Glyoxalase Pathway Enhancement by Morin Derivatives in an Alzheimer's Disease Model.
ACS Chem Neurosci
; 11(3): 356-366, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31909963
19.
Gallium Porphyrin and Gallium Nitrate Synergistically Inhibit Mycobacterial Species by Targeting Different Aspects of Iron/Heme Metabolism.
ACS Infect Dis
; 6(10): 2582-2591, 2020 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32845117
20.
Treatment of Virulent Mycobacterium tuberculosis and HIV Coinfected Macrophages with Gallium Nanoparticles Inhibits Pathogen Growth and Modulates Macrophage Cytokine Production.
mSphere
; 4(4)2019 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31341073