Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

HIV rapidly targets a diverse pool of CD4⁺ T cells to establish productive and latent infections.

Gantner, Pierre; Buranapraditkun, Supranee; Pagliuzza, Amélie; Dufour, Caroline; Pardons, Marion; Mitchell, Julie L; Kroon, Eugène; Sacdalan, Carlo; Tulmethakaan, Nicha; Pinyakorn, Suteeraporn; Robb, Merlin L; Phanuphak, Nittaya; Ananworanich, Jintanat; Hsu, Denise; Vasan, Sandhya; Trautmann, Lydie; Fromentin, Rémi; Chomont, Nicolas.

Immunity ; 56(3): 653-668.e5, 2023 03 14.

Artigo em Inglês | MEDLINE | ID: mdl-36804957

2.

HIV persistence in subsets of CD4+ T cells: 50 shades of reservoirs.

Fromentin, Rémi; Chomont, Nicolas.

Semin Immunol ; 51: 101438, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33272901

3.

Measuring Human Immunodeficiency Virus Reservoirs: Do We Need to Choose Between Quantity and Quality?

Roux, Hélène; Chomont, Nicolas.

J Infect Dis ; 229(3): 635-643, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-37665978

4.

IL-32 Drives the Differentiation of Cardiotropic CD4+ T Cells Carrying HIV DNA in People With HIV.

Ramani, Hardik; Gosselin, Annie; Bunet, Rémi; Jenabian, Mohammad-Ali; Sylla, Mohamed; Pagliuzza, Amélie; Chartrand-Lefebvre, Carl; Routy, Jean-Pierre; Goulet, Jean-Philippe; Thomas, Réjean; Trottier, Benoit; Martel-Laferrière, Valérie; Fortin, Claude; Chomont, Nicolas; Fromentin, Rémi; Landay, Alan L; Durand, Madeleine; Ancuta, Petronela; El-Far, Mohamed; Tremblay, Cecile.

J Infect Dis ; 229(5): 1277-1289, 2024 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-38113908

5.

Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.

Benlarbi, Mehdi; Richard, Jonathan; Bourassa, Catherine; Tolbert, William D; Chartrand-Lefebvre, Carl; Gendron-Lepage, Gabrielle; Sylla, Mohamed; El-Far, Mohamed; Messier-Peet, Marc; Guertin, Camille; Turcotte, Isabelle; Fromentin, Rémi; Verly, Myriam Maude; Prévost, Jérémie; Clark, Andrew; Mothes, Walther; Kaufmann, Daniel E; Maldarelli, Frank; Chomont, Nicolas; Bégin, Philippe; Tremblay, Cécile; Baril, Jean-Guy; Trottier, Benoit; Trottier, Sylvie; Duerr, Ralf; Pazgier, Marzena; Durand, Madeleine; Finzi, Andrés.

J Infect Dis ; 229(3): 763-774, 2024 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-38035854

6.

DAA-mediated HCV cure reduces HIV DNA levels in HCV/HIV coinfected people.

Gobran, Samaa T; Pagliuzza, Amélie; Khedr, Omar; Fert, Augustine; Chomont, Nicolas; Bruneau, Julie; Klein, Marina B; Ancuta, Petronela; Shoukry, Naglaa H.

J Virol ; 97(12): e0110523, 2023 Dec 21.

Artigo em Inglês | MEDLINE | ID: mdl-38051044

7.

HIV-1 DNA and Immune Activation Levels Differ for Long-Lived T-Cells in Lymph Nodes, Compared with Peripheral Blood, during Antiretroviral Therapy.

Mallarino-Haeger, Christina; Pino, Maria; Viox, Elise G; Pagliuzza, Amélie; King, Colin T; Nguyen, Kevin; Harper, Justin L; Aldrete, Sol Del Mar; Cervasi, Barbara; Delman, Keith A; Lowe, Michael C; Chomont, Nicolas; Marconi, Vincent C; Paiardini, Mirko.

J Virol ; 97(4): e0167022, 2023 04 27.

Artigo em Inglês | MEDLINE | ID: mdl-36971588

8.

The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription.

Okoye, Afam A; Fromentin, Rémi; Takata, Hiroshi; Brehm, Jessica H; Fukazawa, Yoshinori; Randall, Bryan; Pardons, Marion; Tai, Vincent; Tang, Jun; Smedley, Jeremy; Axthelm, Michael; Lifson, Jeffrey D; Picker, Louis J; Favre, David; Trautmann, Lydie; Chomont, Nicolas.

PLoS Pathog ; 18(1): e1010245, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-35041707

9.

Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy.

Chiu, Chris Y; Chang, Judy J; Dantanarayana, Ashanti I; Solomon, Ajantha; Evans, Vanessa A; Pascoe, Rachel; Gubser, Céline; Trautman, Lydie; Fromentin, Rémi; Chomont, Nicolas; McMahon, James H; Cameron, Paul U; Rasmussen, Thomas A; Lewin, Sharon R.

J Immunol ; 208(1): 54-62, 2022 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-34853078

10.

Silence, escape and survival drive the persistence of HIV.

Chomont, Nicolas.

Nature ; 614(7947): 236-237, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36599993

11.

Preferential and persistent impact of acute HIV-1 infection on CD4⁺ iNKT cells in colonic mucosa.

Paquin-Proulx, Dominic; Lal, Kerri G; Phuang-Ngern, Yuwadee; Creegan, Matthew; Tokarev, Andrey; Suhkumvittaya, Suchada; Alrubayyi, Aljawharah; Kroon, Eugène; Pinyakorn, Suteeraporn; Slike, Bonnie M; Bolton, Diane L; Krebs, Shelly J; Eller, Leigh Anne; Sajjaweerawan, Chayada; Pagliuzza, Amélie; Chomont, Nicolas; Rerknimitr, Rungsun; Chomchey, Nitiya; Phanuphak, Nittaya; de Souza, Mark S; Michael, Nelson L; Robb, Merlin L; Ananworanich, Jintanat; Sandberg, Johan K; Eller, Michael A; Schuetz, Alexandra.

Proc Natl Acad Sci U S A ; 118(46)2021 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-34753817

12.

Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy.

Turcotte, Isabelle; El-Far, Mohamed; Sadouni, Manel; Chartrand-Lefebvre, Carl; Filali-Mouhim, Ali; Fromentin, Rémi; Chamberland, Annie; Jenabian, Mohammad-Ali; Baril, Jean-Guy; Trottier, Benoit; Thomas, Réjean; Tremblay, Cécile L; Durand, Madeleine; Chomont, Nicolas.

Clin Infect Dis ; 76(7): 1318-1321, 2023 04 03.

Artigo em Inglês | MEDLINE | ID: mdl-36346439

13.

Detecting Sources of Immune Activation and Viral Rebound in HIV Infection.

Wietgrefe, Stephen W; Duan, Lijie; Anderson, Jodi; Marqués, Guillermo; Sanders, Mark; Cummins, Nathan W; Badley, Andrew D; Dobrowolski, Curtis; Karn, Jonathan; Pagliuzza, Amélie; Chomont, Nicolas; Sannier, Gérémy; Dubé, Mathieu; Kaufmann, Daniel E; Zuck, Paul; Wu, Guoxin; Howell, Bonnie J; Reilly, Cavan; Herschhorn, Alon; Schacker, Timothy W; Haase, Ashley T.

J Virol ; 96(15): e0088522, 2022 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-35856674

14.

Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.

Pino, Maria; Pereira Ribeiro, Susan; Pagliuzza, Amélie; Ghneim, Khader; Khan, Anum; Ryan, Emily; Harper, Justin L; King, Colin T; Welbourn, Sarah; Micci, Luca; Aldrete, Sol; Delman, Keith A; Stuart, Theron; Lowe, Michael; Brenchley, Jason M; Derdeyn, Cynthia A; Easley, Kirk; Sekaly, Rafick P; Chomont, Nicolas; Paiardini, Mirko; Marconi, Vincent C.

PLoS Pathog ; 17(8): e1009825, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34449812

15.

RALDH Activity Induced by Bacterial/Fungal Pathogens in CD16⁺ Monocyte-Derived Dendritic Cells Boosts HIV Infection and Outgrowth in CD4⁺ T Cells.

Cattin, Amélie; Wacleche, Vanessa Sue; Fonseca Do Rosario, Natalia; Marchand, Laurence Raymond; Dias, Jonathan; Gosselin, Annie; Cohen, Eric A; Estaquier, Jérôme; Chomont, Nicolas; Routy, Jean-Pierre; Ancuta, Petronela.

J Immunol ; 206(11): 2638-2651, 2021 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-34031148

16.

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy.

Meziane, Oussama; Alexandrova, Yulia; Olivenstein, Ronald; Dupuy, Franck P; Salahuddin, Syim; Thomson, Elaine; Orlova, Marianna; Schurr, Erwin; Ancuta, Petronela; Durand, Madeleine; Chomont, Nicolas; Estaquier, Jérôme; Bernard, Nicole F; Costiniuk, Cecilia T; Jenabian, Mohammad-Ali.

J Immunol ; 206(3): 641-651, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33318292

17.

Cellular Activation, Differentiation, and Proliferation Influence the Dynamics of Genetically Intact Proviruses Over Time.

Horsburgh, Bethany A; Hiener, Bonnie; Fisher, Katie; Lee, Eunok; Morgan, Hannah; Eden, John-Sebastian; von Stockenstrom, Susanne; Odevall, Lina; Milush, Jeffrey M; Hoh, Rebecca; Fromentin, Rémi; Chomont, Nicolas; Hecht, Frederick M; Schlub, Timothy E; Deeks, Steven G; Palmer, Sarah.

J Infect Dis ; 225(7): 1168-1178, 2022 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-34037766

18.

Impact of Tamoxifen on Vorinostat-Induced Human Immunodeficiency Virus Expression in Women on Antiretroviral Therapy: AIDS Clinical Trials Group A5366, The MOXIE Trial.

Scully, Eileen P; Aga, Evgenia; Tsibris, Athe; Archin, Nancie; Starr, Kate; Ma, Qing; Morse, Gene D; Squires, Kathleen E; Howell, Bonnie J; Wu, Guoxin; Hosey, Lara; Sieg, Scott F; Ehui, Lynsay; Giguel, Francoise; Coxen, Kendyll; Dobrowolski, Curtis; Gandhi, Monica; Deeks, Steve; Chomont, Nicolas; Connick, Elizabeth; Godfrey, Catherine; Karn, Jonathan; Kuritzkes, Daniel R; Bosch, Ronald J; Gandhi, Rajesh T.

Clin Infect Dis ; 75(8): 1389-1396, 2022 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-35176755

19.

Fingolimod inhibits multiple stages of the HIV-1 life cycle.

Resop, Rachel S; Fromentin, Rémi; Newman, Daniel; Rigsby, Hawley; Dubrovsky, Larisa; Bukrinsky, Michael; Chomont, Nicolas; Bosque, Alberto.

PLoS Pathog ; 16(8): e1008679, 2020 08.

Artigo em Inglês | MEDLINE | ID: mdl-32790802

20.

Combination Immune Checkpoint Blockade to Reverse HIV Latency.

Van der Sluis, Renée M; Kumar, Nitasha A; Pascoe, Rachel D; Zerbato, Jennifer M; Evans, Vanessa A; Dantanarayana, Ashanti I; Anderson, Jenny L; Sékaly, Rafick P; Fromentin, Rémi; Chomont, Nicolas; Cameron, Paul U; Lewin, Sharon R.

J Immunol ; 204(5): 1242-1254, 2020 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-31988180

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