Detalhe da pesquisa
1.
Drug Resistance Assessed in a Phase 3 Clinical Trial of Maribavir Therapy for Refractory or Resistant Cytomegalovirus Infection in Transplant Recipients.
J Infect Dis
; 229(2): 413-421, 2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37506264
2.
Use of next-generation sequencing to detect mutations associated with antiviral drug resistance in cytomegalovirus.
J Clin Microbiol
; 61(10): e0042923, 2023 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750719
3.
Drug Resistance Mutations and Associated Phenotypes Detected in Clinical Trials of Maribavir for Treatment of Cytomegalovirus Infection.
J Infect Dis
; 226(4): 576-584, 2022 09 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32726419
4.
Highly Conserved Interaction Profiles between Clinically Relevant Mutants of the Cytomegalovirus CDK-like Kinase pUL97 and Human Cyclins: Functional Significance of Cyclin H.
Int J Mol Sci
; 23(19)2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36233116
5.
Letermovir Resistance Analysis in a Clinical Trial of Cytomegalovirus Prophylaxis for Hematopoietic Stem Cell Transplant Recipients.
J Infect Dis
; 221(7): 1117-1126, 2020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31781762
6.
Definitions of Resistant and Refractory Cytomegalovirus Infection and Disease in Transplant Recipients for Use in Clinical Trials.
Clin Infect Dis
; 68(8): 1420-1426, 2019 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30137245
7.
Emergence of letermovir resistance in a lung transplant recipient with ganciclovir-resistant cytomegalovirus infection.
Am J Transplant
; 18(12): 3060-3064, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30286286
8.
New Locus of Drug Resistance in the Human Cytomegalovirus UL56 Gene Revealed by In Vitro Exposure to Letermovir and Ganciclovir.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29914965
9.
Comparison of Cytomegalovirus Terminase Gene Mutations Selected after Exposure to Three Distinct Inhibitor Compounds.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28827420
10.
Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene.
J Clin Microbiol
; 55(7): 2098-2104, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446569
11.
Analysis of Mutations in the Gene Encoding Cytomegalovirus DNA Polymerase in a Phase 2 Clinical Trial of Brincidofovir Prophylaxis.
J Infect Dis
; 214(1): 32-5, 2016 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26941282
12.
Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.
J Biol Chem
; 290(32): 19666-80, 2015 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26100623
13.
Novel Cytomegalovirus UL54 DNA Polymerase Gene Mutations Selected In Vitro That Confer Brincidofovir Resistance.
Antimicrob Agents Chemother
; 60(6): 3845-8, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044553
14.
Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance.
Antimicrob Agents Chemother
; 59(10): 6588-93, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26259791
15.
Approach to drug-resistant cytomegalovirus in transplant recipients.
Curr Opin Infect Dis
; 28(4): 293-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098499
16.
Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility.
J Virol
; 88(9): 4776-85, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24522923
17.
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.
PLoS Pathog
; 9(4): e1003297, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23637597
18.
Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial.
J Infect Dis
; 209(8): 1219-26, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24273181
19.
Cytomegalovirus mutants resistant to ganciclovir and cidofovir differ in susceptibilities to synguanol and its 6-ether and 6-thioether derivatives.
Antimicrob Agents Chemother
; 58(3): 1809-12, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24379208
20.
Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing.
Antimicrob Agents Chemother
; 58(8): 4697-702, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24890586