RESUMO
Endothelial microparticle (EMP) is a biomarker for endothelial dysfunction. The aim of this study is to investigate the utility of EMP in evaluating coronary intermediate lesions. Participants included 49 patients with coronary intermediate lesions and 24 subjects with normal coronary arteries. Among these subjects, 28 patients accepted fractional flow reserve (FFR). Results showed that level of EMP was significantly higher in the intermediate lesion group. No correlation was found between EMP and FFR value, suggesting that circulating EMP is a systemic marker rather than a focal one.
Assuntos
Micropartículas Derivadas de Células/metabolismo , Doença da Artéria Coronariana/fisiopatologia , Endotelina-1/metabolismo , Reserva Fracionada de Fluxo Miocárdico , Óxido Nítrico Sintase Tipo III/metabolismo , Óxido Nítrico/metabolismo , Idoso , Biomarcadores/sangue , Biomarcadores/metabolismo , Distribuição de Qui-Quadrado , Doença da Artéria Coronariana/diagnóstico , Doença da Artéria Coronariana/metabolismo , Endotelina-1/sangue , Endotélio Vascular/citologia , Endotélio Vascular/metabolismo , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Óxido Nítrico/sangue , Óxido Nítrico Sintase Tipo III/sangueRESUMO
This study was to investigate the utility of platelet-derived microparticles (PMPs) to detect coronary intermediate lesions. Fifty-two patients with coronary intermediate lesions and 24 subjects with normal coronary arteries were enrolled. In the former group, 31 patients accepted both intravenous ultrasound (IVUS) and fractional flow reserve (FFR). Results showed that the level of PMPs was significantly higher in the intermediate lesion group and PMPs titer was positively correlated with thromboxane B2, platelet activating factor, endothelin-1, and neutrophil to lymphocyte ratio. The level of PMPs also increased after IVUS/FFR, suggesting platelet activation and endothelial dysfunction.