Detalhe da pesquisa
1.
Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method.
Xenobiotica
; 54(3): 138-149, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38501457
2.
Synthesis and biological evaluation of N-(benzene sulfonyl)acetamide derivatives as anti-inflammatory and analgesic agents with COX-2/5-LOX/TRPV1 multifunctional inhibitory activity.
Bioorg Med Chem Lett
; 80: 129101, 2023 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36481449
3.
LC-MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first-in-human pharmacokinetic study.
Biomed Chromatogr
; 37(2): e5542, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36330676
4.
Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H1 antagonize activities.
Bioorg Med Chem Lett
; 29(24): 126712, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31679973
5.
Profiling and Preparation of Metabolites from Pyragrel in Human Urine by Online Solid-Phase Extraction Coupled with High Performance Liquid Chromatography Tandem Mass Spectrometry Followed by a Macroporous Resin-Based Purification Approach.
Molecules
; 22(3)2017 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28335566
6.
Li, P HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.
Exp Neurol
; 371: 114583, 2024 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884189
7.
Discovery of the novel and potent histamine H1 receptor antagonists for treatment of allergic diseases.
Eur J Med Chem
; 268: 116197, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38368709
8.
Design, Synthesis, and Biological Evaluation of Pierardine Derivatives as Novel Brain-Penetrant and In Vivo Potent NMDAR-GluN2B Antagonists for Ischemic Stroke Treatment.
J Med Chem
; 67(5): 3358-3384, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38413367
9.
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.
Bioorg Med Chem Lett
; 23(7): 1993-6, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23481647
10.
Liquiritin Attenuates Angiotensin II-Induced Cardiomyocyte Hypertrophy via ATE1/TAK1-JNK1/2 Pathway.
Evid Based Complement Alternat Med
; 2022: 7861338, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35341136
11.
Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.
Eur J Med Chem
; 227: 113876, 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34710748
12.
Discovery of the First Selective IDO2 Inhibitor As Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.
J Med Chem
; 65(21): 14348-14365, 2022 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35952367
13.
Design, synthesis and biological evaluation of novel benzoxaborole derivatives as potent PDE4 inhibitors for topical treatment of atopic dermatitis.
Eur J Med Chem
; 213: 113171, 2021 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33482600
14.
Discovery of the First Potent IDO1/IDO2 Dual Inhibitors: A Promising Strategy for Cancer Immunotherapy.
J Med Chem
; 64(24): 17950-17968, 2021 12 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34854662
15.
Gastroprotective Activity of the Total Flavones from Abelmoschus manihot (L.) Medic Flowers.
Evid Based Complement Alternat Med
; 2020: 6584945, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184895
16.
Semi-Mechanistic Modeling of HY-021068 Based on Irreversible Inhibition of Thromboxane Synthetase.
Front Pharmacol
; 11: 588286, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33390963
17.
Regorafenib-loaded poly (lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma.
Asian J Pharm Sci
; 15(6): 739-751, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-33363629
18.
Discovery of Novel Dual Poly(ADP-ribose)polymerase and Phosphoinositide 3-Kinase Inhibitors as a Promising Strategy for Cancer Therapy.
J Med Chem
; 63(1): 122-139, 2020 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31846325
19.
Phase I Trial of Pyragrel, a Novel Thromboxane Synthetase Inhibitor, to Evaluate the Safety, Tolerability, and Pharmacokinetics in Healthy Volunteers.
Front Pharmacol
; 10: 1231, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31708774
20.
Discovery of novel limonin derivatives as potent anti-inflammatory and analgesic agents.
Chin J Nat Med
; 16(3): 231-240, 2018 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-29576060