"Smart markets": harnessing the potential of new technologies for endemic and emerging infectious disease surveillance in traditional food markets.

Emerging and endemic zoonotic diseases continue to threaten human and animal health, our social fabric, and the global economy. Zoonoses frequently emerge from congregate interfaces where multiple animal species and humans coexist, including farms and markets. Traditional food markets are widespread across the globe and create an interface where domestic and wild animals interact among themselves and with humans, increasing the risk of pathogen spillover. Despite decades of evidence linking markets to disease outbreaks across the world, there remains a striking lack of pathogen surveillance programs that can relay timely, cost-effective, and actionable information to decision-makers to protect human and animal health. However, the strategic incorporation of environmental surveillance systems in markets coupled with novel pathogen detection strategies can create an early warning system capable of alerting us to the risk of outbreaks before they happen. Here, we explore the concept of "smart" markets that utilize continuous surveillance systems to monitor the emergence of zoonotic pathogens with spillover potential.IMPORTANCEFast detection and rapid intervention are crucial to mitigate risks of pathogen emergence, spillover and spread-every second counts. However, comprehensive, active, longitudinal surveillance systems at high-risk interfaces that provide real-time data for action remain lacking. This paper proposes "smart market" systems harnessing cutting-edge tools and a range of sampling techniques, including wastewater and air collection, multiplex assays, and metagenomic sequencing. Coupled with robust response pathways, these systems could better enable Early Warning and bolster prevention efforts.

Ingrained: Rice farming and the risk of zoonotic spillover, examples from Cambodia.

Rice cultivation in Southeast Asia is a One Health interface intersecting human, animal, and environmental health. This complexity creates a potential for zoonotic transmission between diverse reservoirs. Bats harbor viruses like Nipah; mosquitoes transmit arboviruses; rodents spread hantaviruses. Domestic animals- including pigs with influenza and dogs with rabies and aquatic animals can also transmit pathogens. Climate change and urbanization may further disrupt rice agro-ecologies. This paper explores animal viral reservoirs, vectors, and historical practices associated with risk in rice farming. Climate and land use changes could enhance spillover. Solutions are proposed, including surveillance of animals, vectors, water, and air to detect threats before major outbreaks, such as improved biosecurity, hygiene, and livestock vaccinations. Ecological viral surveillance and agricultural interventions together can reduce zoonotic transmission from rice farming.