Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.

Rutz, Sascha; Kayagaki, Nobuhiko; Phung, Qui T; Eidenschenk, Celine; Noubade, Rajkumar; Wang, Xiaoting; Lesch, Justin; Lu, Rongze; Newton, Kim; Huang, Oscar W; Cochran, Andrea G; Vasser, Mark; Fauber, Benjamin P; DeVoss, Jason; Webster, Joshua; Diehl, Lauri; Modrusan, Zora; Kirkpatrick, Donald S; Lill, Jennie R; Ouyang, Wenjun; Dixit, Vishva M.

Nature ; 518(7539): 417-21, 2015 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-25470037

2.

Expansion of the ISWI chromatin remodeler family with new active complexes.

Oppikofer, Mariano; Bai, Tianyi; Gan, Yutian; Haley, Benjamin; Liu, Peter; Sandoval, Wendy; Ciferri, Claudio; Cochran, Andrea G.

EMBO Rep ; 18(10): 1697-1706, 2017 10.

Artigo em Inglês | MEDLINE | ID: mdl-28801535

3.

An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.

Vinogradova, Maia; Gehling, Victor S; Gustafson, Amy; Arora, Shilpi; Tindell, Charles A; Wilson, Catherine; Williamson, Kaylyn E; Guler, Gulfem D; Gangurde, Pranoti; Manieri, Wanda; Busby, Jennifer; Flynn, E Megan; Lan, Fei; Kim, Hyo-Jin; Odate, Shobu; Cochran, Andrea G; Liu, Yichin; Wongchenko, Matthew; Yang, Yibin; Cheung, Tommy K; Maile, Tobias M; Lau, Ted; Costa, Michael; Hegde, Ganapati V; Jackson, Erica; Pitti, Robert; Arnott, David; Bailey, Christopher; Bellon, Steve; Cummings, Richard T; Albrecht, Brian K; Harmange, Jean-Christophe; Kiefer, James R; Trojer, Patrick; Classon, Marie.

Nat Chem Biol ; 12(7): 531-8, 2016 07.

Artigo em Inglês | MEDLINE | ID: mdl-27214401

4.

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.

Ghosh, Srimoyee; Taylor, Alexander; Chin, Melissa; Huang, Hon-Ren; Conery, Andrew R; Mertz, Jennifer A; Salmeron, Andres; Dakle, Pranal J; Mele, Deanna; Cote, Alexandre; Jayaram, Hari; Setser, Jeremy W; Poy, Florence; Hatzivassiliou, Georgia; DeAlmeida-Nagata, Denise; Sandy, Peter; Hatton, Charlie; Romero, F Anthony; Chiang, Eugene; Reimer, Thornik; Crawford, Terry; Pardo, Eneida; Watson, Venita G; Tsui, Vickie; Cochran, Andrea G; Zawadzke, Laura; Harmange, Jean-Christophe; Audia, James E; Bryant, Barbara M; Cummings, Richard T; Magnuson, Steven R; Grogan, Jane L; Bellon, Steve F; Albrecht, Brian K; Sims, Robert J; Lora, Jose M.

J Biol Chem ; 291(25): 13014-27, 2016 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-27056325

5.

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

Crawford, Terry D; Vartanian, Steffan; Côté, Alexandre; Bellon, Steve; Duplessis, Martin; Flynn, E Megan; Hewitt, Michael; Huang, Hon-Ren; Kiefer, James R; Murray, Jeremy; Nasveschuk, Christopher G; Pardo, Eneida; Romero, F Anthony; Sandy, Peter; Tang, Yong; Taylor, Alexander M; Tsui, Vickie; Wang, Jian; Wang, Shumei; Zawadzke, Laura; Albrecht, Brian K; Magnuson, Steven R; Cochran, Andrea G; Stokoe, David.

Bioorg Med Chem Lett ; 27(15): 3534-3541, 2017 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-28606761

6.

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex.

Bentley, Matthew L; Corn, Jacob E; Dong, Ken C; Phung, Qui; Cheung, Tommy K; Cochran, Andrea G.

EMBO J ; 30(16): 3285-97, 2011 Jul 19.

Artigo em Inglês | MEDLINE | ID: mdl-21772249

7.

GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1.

Cochran, Andrea G; Flynn, Megan.

J Med Chem ; 66(18): 13116-13134, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37702400

8.

Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation.

Miller, Gregory M; Flynn, E Megan; Tom, Jeffrey; Song, Aimin; Cochran, Andrea G.

ACS Chem Biol ; 17(5): 1022-1029, 2022 05 20.

Artigo em Inglês | MEDLINE | ID: mdl-35467836

9.

GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1.

Taylor, Alexander M; Bailey, Chris; Belmont, Lisa D; Campbell, Robert; Cantone, Nico; Côté, Alexandre; Crawford, Terry D; Cummings, Richard; DeMent, Kevin; Duplessis, Martin; Flynn, Megan; Good, Andrew C; Huang, Hon-Ren; Joshi, Shivangi; Leblanc, Yves; Murray, Jeremy; Nasveschuk, Christopher G; Neiss, Adrianne; Poy, Florence; Romero, F Anthony; Sandy, Peter; Tang, Yong; Tsui, Vickie; Zawadzke, Laura; Sims, Robert J; Audia, James E; Bellon, Steven F; Magnuson, Steven R; Albrecht, Brian K; Cochran, Andrea G.

J Med Chem ; 65(16): 11177-11186, 2022 08 25.

Artigo em Inglês | MEDLINE | ID: mdl-35930799

10.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis, Eric; Tam, Christine; Franke, Yvonne; Bazan, J Fernando; Ernst, James; Hwang, Jiyoung; Costa, Mike; Cochran, Andrea G; Hannoush, Rami N.

J Biol Chem ; 285(12): 9172-9, 2010 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-20093360

11.

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.

Bourhis, Eric; Lingel, Andreas; Phung, Qui; Fairbrother, Wayne J; Cochran, Andrea G.

Biochemistry ; 48(29): 6783-93, 2009 Jul 28.

Artigo em Inglês | MEDLINE | ID: mdl-19530738

12.

Aurora A: target invalidated?

Cochran, Andrea G.

Chem Biol ; 15(6): 525-6, 2008 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18559262

13.

Bromodomains: a new target class for drug development.

Cochran, Andrea G; Conery, Andrew R; Sims, Robert J.

Nat Rev Drug Discov ; 18(8): 609-628, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31273347

14.

GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like.

Wang, Shumei; Tsui, Vickie; Crawford, Terry D; Audia, James E; Burdick, Daniel J; Beresini, Maureen H; Côté, Alexandre; Cummings, Richard; Duplessis, Martin; Flynn, E Megan; Hewitt, Michael C; Huang, Hon-Ren; Jayaram, Hariharan; Jiang, Ying; Joshi, Shivangi; Murray, Jeremy; Nasveschuk, Christopher G; Pardo, Eneida; Poy, Florence; Romero, F Anthony; Tang, Yong; Taylor, Alexander M; Wang, Jian; Xu, Zhaowu; Zawadzke, Laura E; Zhu, Xiaoyu; Albrecht, Brian K; Magnuson, Steven R; Bellon, Steve; Cochran, Andrea G.

J Med Chem ; 61(20): 9301-9315, 2018 10 25.

Artigo em Inglês | MEDLINE | ID: mdl-30289257

15.

Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists.

Li, Bing; Russell, Stephen J; Compaan, Deanne M; Totpal, Klara; Marsters, Scot A; Ashkenazi, Avi; Cochran, Andrea G; Hymowitz, Sarah G; Sidhu, Sachdev S.

J Mol Biol ; 361(3): 522-36, 2006 Aug 18.

Artigo em Inglês | MEDLINE | ID: mdl-16859704

16.

Non-canonical reader modules of BAZ1A promote recovery from DNA damage.

Oppikofer, Mariano; Sagolla, Meredith; Haley, Benjamin; Zhang, Hui-Min; Kummerfeld, Sarah K; Sudhamsu, Jawahar; Flynn, E Megan; Bai, Tianyi; Zhang, Jennifer; Ciferri, Claudio; Cochran, Andrea G.

Nat Commun ; 8(1): 862, 2017 10 11.

Artigo em Inglês | MEDLINE | ID: mdl-29021563

17.

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).

Crawford, Terry D; Audia, James E; Bellon, Steve; Burdick, Daniel J; Bommi-Reddy, Archana; Côté, Alexandre; Cummings, Richard T; Duplessis, Martin; Flynn, E Megan; Hewitt, Michael; Huang, Hon-Ren; Jayaram, Hariharan; Jiang, Ying; Joshi, Shivangi; Kiefer, James R; Murray, Jeremy; Nasveschuk, Christopher G; Neiss, Arianne; Pardo, Eneida; Romero, F Anthony; Sandy, Peter; Sims, Robert J; Tang, Yong; Taylor, Alexander M; Tsui, Vickie; Wang, Jian; Wang, Shumei; Wang, Yongyun; Xu, Zhaowu; Zawadzke, Laura; Zhu, Xiaoqin; Albrecht, Brian K; Magnuson, Steven R; Cochran, Andrea G.

ACS Med Chem Lett ; 8(7): 737-741, 2017 Jul 13.

Artigo em Inglês | MEDLINE | ID: mdl-28740608

18.

Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300.

Crawford, Terry D; Romero, F Anthony; Lai, Kwong Wah; Tsui, Vickie; Taylor, Alexander M; de Leon Boenig, Gladys; Noland, Cameron L; Murray, Jeremy; Ly, Justin; Choo, Edna F; Hunsaker, Thomas L; Chan, Emily W; Merchant, Mark; Kharbanda, Samir; Gascoigne, Karen E; Kaufman, Susan; Beresini, Maureen H; Liao, Jiangpeng; Liu, Wenfeng; Chen, Kevin X; Chen, Zhongguo; Conery, Andrew R; Côté, Alexandre; Jayaram, Hariharan; Jiang, Ying; Kiefer, James R; Kleinheinz, Tracy; Li, Yingjie; Maher, Jonathan; Pardo, Eneida; Poy, Florence; Spillane, Kerry L; Wang, Fei; Wang, Jian; Wei, Xiaocang; Xu, Zhaowu; Xu, Zhongya; Yen, Ivana; Zawadzke, Laura; Zhu, Xiaoyu; Bellon, Steven; Cummings, Richard; Cochran, Andrea G; Albrecht, Brian K; Magnuson, Steven.

J Med Chem ; 59(23): 10549-10563, 2016 12 08.

Artigo em Inglês | MEDLINE | ID: mdl-27682507

19.

Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.

Crawford, Terry D; Tsui, Vickie; Flynn, E Megan; Wang, Shumei; Taylor, Alexander M; Côté, Alexandre; Audia, James E; Beresini, Maureen H; Burdick, Daniel J; Cummings, Richard; Dakin, Les A; Duplessis, Martin; Good, Andrew C; Hewitt, Michael C; Huang, Hon-Ren; Jayaram, Hariharan; Kiefer, James R; Jiang, Ying; Murray, Jeremy; Nasveschuk, Christopher G; Pardo, Eneida; Poy, Florence; Romero, F Anthony; Tang, Yong; Wang, Jian; Xu, Zhaowu; Zawadzke, Laura E; Zhu, Xiaoyu; Albrecht, Brian K; Magnuson, Steven R; Bellon, Steve; Cochran, Andrea G.

J Med Chem ; 59(11): 5391-402, 2016 06 09.

Artigo em Inglês | MEDLINE | ID: mdl-27219867

20.

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

Taylor, Alexander M; Côté, Alexandre; Hewitt, Michael C; Pastor, Richard; Leblanc, Yves; Nasveschuk, Christopher G; Romero, F Anthony; Crawford, Terry D; Cantone, Nico; Jayaram, Hariharan; Setser, Jeremy; Murray, Jeremy; Beresini, Maureen H; de Leon Boenig, Gladys; Chen, Zhongguo; Conery, Andrew R; Cummings, Richard T; Dakin, Leslie A; Flynn, E Megan; Huang, Oscar W; Kaufman, Susan; Keller, Patricia J; Kiefer, James R; Lai, Tommy; Li, Yingjie; Liao, Jiangpeng; Liu, Wenfeng; Lu, Henry; Pardo, Eneida; Tsui, Vickie; Wang, Jian; Wang, Yongyun; Xu, Zhaowu; Yan, Fen; Yu, Dong; Zawadzke, Laura; Zhu, Xiaoqin; Zhu, Xiaoyu; Sims, Robert J; Cochran, Andrea G; Bellon, Steve; Audia, James E; Magnuson, Steven; Albrecht, Brian K.

ACS Med Chem Lett ; 7(5): 531-6, 2016 May 12.

Artigo em Inglês | MEDLINE | ID: mdl-27190605

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