Detalhe da pesquisa
1.
Antibody-Proteolysis Targeting Chimera Conjugate Enables Selective Degradation of Receptor-Interacting Serine/Threonine-Protein Kinase 2 in HER2+ Cell Lines.
Bioconjug Chem
; 34(11): 2049-2054, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37917829
2.
Electrochemical Synthesis of Isoxazolines: Method and Mechanism.
Chemistry
; 28(13): e202103728, 2022 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35076117
3.
Hi-JAK-ing the ubiquitin system: The design and physicochemical optimisation of JAK PROTACs.
Bioorg Med Chem
; 28(5): 115326, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32001089
4.
Synthesis of α-substituted vinylsulfonium salts and their application as annulation reagents in the formation of epoxide- and cyclopropane-fused heterocycles.
J Org Chem
; 79(21): 10226-39, 2014 Nov 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25310872
5.
A 3,4-trans-fused cyclic protecting group facilitates α-selective catalytic synthesis of 2-deoxyglycosides.
Angew Chem Int Ed Engl
; 53(31): 8190-4, 2014 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24953049
6.
Synthesis and Evaluation of Small Molecule Inhibitors of the Androgen Receptor N-Terminal Domain.
ACS Med Chem Lett
; 14(12): 1800-1806, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116409
7.
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Proc Natl Acad Sci U S A
; 106(43): 18114-9, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19822747
8.
α-Selective organocatalytic synthesis of 2-deoxygalactosides.
Angew Chem Int Ed Engl
; 51(36): 9152-5, 2012 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22887611
9.
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem
; 65(1): 633-664, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928601
10.
Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity.
Bioorg Med Chem Lett
; 21(4): 1126-33, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21257309
11.
Reaction of 1,1'-divinyl ferrocene with one-electron oxidants: entry into functionalised [4]ferrocenophanes and observation of an isotope-dependent chemoselectivity effect.
Chemistry
; 16(19): 5769-77, 2010 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-20391576
12.
Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.
Bioorg Med Chem Lett
; 20(19): 5803-6, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20732811
13.
Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 19(16): 4846-50, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19592247
14.
Aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 19(1): 158-62, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19019676
15.
Nonsteroidal glucocorticoid agonists: tetrahydronaphthalenes with alternative steroidal A-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity.
J Med Chem
; 50(26): 6519-34, 2007 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-18038970
16.
Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst.
Org Lett
; 18(17): 4222-5, 2016 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27529800
17.
Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma.
J Med Chem
; 59(5): 1711-26, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26861551
18.
Plasmachemical surface functionalised beads: versatile tailored supports for polymer assisted organic synthesis.
Chem Commun (Camb)
; (12): 1402-3, 2004 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-15179485
19.
Synthesis of Phosphoramides for the Lewis Base-Catalyzed Allylation and Aldol Addition Reactions.
J Org Chem
; 64(6): 1958-1967, 1999 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674289
20.
A practical drug discovery project at the undergraduate level.
Drug Discov Today
; 18(23-24): 1158-72, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24051399