Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients.

Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain- (DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF-α in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72 h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8. In recipients with PGD the donor's plasma levels of TNF-α were higher. The post-operative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF-α plasma levels in donors are associated with a higher incidence of PGD.

[Sexuality in older women]. / Sexualidad en las mujeres mayores.

OBJECTIVES: To determine the prevalence of sexual relations in women >or=65 years. To determine factors that affect their activity and interest in sex. To evaluate the impact on their quality of life. DESIGN. Descriptive, cross-sectional study by means of survey. SETTING: Palacio de Segovia Health Centre, Madrid, Spain. Primary care. PARTICIPANTS: Women >or=65 years old. Criteria of exclusion: bed-ridden women, with psychiatric disease and/or moderate-severe cognitive deterioration. Sequential selection from 10 medical lists. MAIN MEASUREMENTS: Social and demographic, medical, geriatric (Katz and Lawton-Brody index), quality of life (WONCA sheets), variables on sexuality. RESULTS: One hundred and sixty two women. Mean age, 74.7 (7.8). Sixty one women with a stable partner (37.7%). Thirty four maintained sexual relations (20.98%), 61.8% (21) of them with coitus: these were satisfactory for 29 women (85.3%). For 50 (30.8%), communication was the most important aspect of sexuality. The lower their age, the more sexual relations they had (P<.022; odds ratio [OR]=0.85; 0.74-0.97). Of 115 women satisfied with the relations of their youth, 28.7% maintained sexual relations now (P<.003; OR=17; 1.7-178.8). The 23.9% maintained their sexual desire, though their partners had more interest in sex (50.9%). Women with stable partners and high self-esteem had more sexual relations than those who had neither, with a significant difference in both cases (P<.001). Maintaining sexual relations is a dependent factor on the Katz index (P<.007). The 32.2% of women thought that their sex life had changed for the worse, while 30.12% (20.54+19.17) thought their sex life had not changed or had improved. CONCLUSIONS: One of every 4 women >64 years old maintain sexual relations. Factors that determine sexual activity are: self-esteem, having a partner, sexual desire, previous sexual history, and the Katz index. Sexual relations are independent of quality of life.

[Variable measurement in urologic clinical research]. / La medición de las variables en la investigación clínica urológica.

Epidemiology develops measurements that allow to quantify the occurrence of disease within the population. There are three types of measurements: frequency measurements, explained in this article; association measurements, between the occurrence of disease and some characteristics, the effect of which on the disease is what they intend to measure; and measurements of the potential impact that modification or disappearance of some risk factors would have on the occurrence of disease in the population. The first objective of epidemiological studies is the knowledge of the frequency of disease. There are three basic measurements of frequency of a disease. Prevalence measures the proportion of people that has it in a given moment. Cumulative incidence measures the proportion of people that convert from non-sick individual to sick individual during a specified period of time. Incidence rate is a measure of the instantaneous strength of occurrence of the disease.

[Statistics as support tool and not as a decision tool]. / La estadística como una herramienta de apoyo y no como una herramienta de decisión.

The use of statistics in medical articles has risen a lot during the last decades, however it is used in a thoughtless manner in many instances. Today, Statistics is the only tool that allows the medical researcher to obtain results and benefits from those studies the relationships of which can not be interpreted from a determinist perspective, because it is a branch of applied mathematics objective of which is to manage and quantify the uncertainty of the available information, to support decision taking. The objective of this article is to review the basic statistical concepts that every doctor should know to be able to perform and/or detect quality research, as well as to underline the most frequent errors committed when interpreting statistical results. We review the general concepts about data synthesis and differentiation of the different types of measurements, hypothesis testing and errors that can be committed doing it, the real meaning of the "p" value, differentiation between statistically significant and clinically relevant results, the importance of confidence intervals as a measure of significance and clinical relevance, the confusion generated between two concepts that are different as standard deviation and standard error, and the criteria that govern the selection of the adequate statistical tests to evaluate relationships between variables.

[Writing an original research article]. / Elaboración de un artículo original de investigación.

Publication of a scientific work is the final and obligatory stage of any research. Among the various existing types of medical publications, the research original article is the prototype of scientific article. Its finality is to communicate the investigation undertaken to the reader in a coherent, clear and precise manner. With that purpose, the discoveries found by the authors as an answer to a hypothesis are presented and discussed. To send the original article to a biomedical journal, the manuscript should present some adequate formal characteristics, in addition to contain scientifically valid information. That can be achieved by complying with the rules past by the International Committee of Biomedical Journal Editors which have been adopted by a great number of scientific journals as publication requisites. The objective of this article is to describe the structure of the various parts (first page, abstract, introduction, material and methods, results, discussion, and bibliographic references) that constitute the format of the research original article, exposing the main adverse to be avoided during its preparation.