Detalhe da pesquisa
1.
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nature
; 538(7625): 344-349, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27602946
2.
Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)-H Arylation.
J Am Chem Soc
; 139(32): 11300-11306, 2017 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28732448
3.
Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.
J Infect Dis
; 211(7): 1097-103, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25336726
4.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
J Am Chem Soc
; 137(24): 7929-34, 2015 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26042473
5.
Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.
Proc Natl Acad Sci U S A
; 108(17): 6751-6, 2011 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21383141
6.
Bicyclic Pyrrolidine Inhibitors of Toxoplasma gondii Phenylalanine t-RNA Synthetase with Antiparasitic Potency In Vitro and Brain Exposure.
ACS Infect Dis
; 2024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38743643
7.
Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure.
bioRxiv
; 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38464220
8.
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development.
Structure
; 30(7): 962-972.e3, 2022 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35460612
9.
Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase.
Nat Commun
; 13(1): 459, 2022 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35075105
10.
Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.
J Org Chem
; 76(19): 8042-8, 2011 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21875084
11.
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.
Nat Commun
; 12(1): 343, 2021 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33436639
12.
An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.
J Am Chem Soc
; 132(47): 16962-76, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21067169
13.
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase.
Sci Transl Med
; 12(563)2020 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32998973
14.
Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.
Cell Chem Biol
; 25(12): 1506-1518.e13, 2018 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30318461
15.
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.
ACS Infect Dis
; 4(10): 1499-1507, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30058798
16.
Novel tricyclic glycal-based TRIB1 inducers that reprogram LDL metabolism in hepatic cells.
Medchemcomm
; 9(11): 1831-1842, 2018 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30542533
17.
An approach to skeletal diversity using functional group pairing of multifunctional scaffolds.
Org Lett
; 9(11): 2123-6, 2007 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17472394
18.
High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.
Cell Host Microbe
; 19(1): 114-26, 2016 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26749441
19.
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria.
ACS Infect Dis
; 2(4): 281-293, 2016 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275010
20.
Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.
PLoS Negl Trop Dis
; 9(9): e0004094, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407168