Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Hallmarks of neurodegenerative diseases.

Wilson, David M; Cookson, Mark R; Van Den Bosch, Ludo; Zetterberg, Henrik; Holtzman, David M; Dewachter, Ilse.

Cell ; 186(4): 693-714, 2023 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-36803602

2.

A feedforward loop links Gaucher and Parkinson's diseases?

Cookson, Mark R.

Cell ; 146(1): 9-11, 2011 Jul 08.

Artigo em Inglês | MEDLINE | ID: mdl-21729776

3.

Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

Mamais, Adamantios; Kluss, Jillian H; Bonet-Ponce, Luis; Landeck, Natalie; Langston, Rebekah G; Smith, Nathan; Beilina, Alexandra; Kaganovich, Alice; Ghosh, Manik C; Pellegrini, Laura; Kumaran, Ravindran; Papazoglou, Ioannis; Heaton, George R; Harvey, Kirsten; Bandopadhyay, Rina; Maio, Nunziata; Kim, Changyoun; LaVoie, Matthew J; Gershlick, David C; Cookson, Mark R.

PLoS Biol ; 20(5): e3001621, 2022 May.

Artigo em Inglês | MEDLINE | ID: mdl-35507910

4.

Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.

Matsuki, Tohru; Matthews, Russell T; Cooper, Jonathan A; van der Brug, Marcel P; Cookson, Mark R; Hardy, John A; Olson, Eric C; Howell, Brian W.

Cell ; 143(5): 826-36, 2010 Nov 24.

Artigo em Inglês | MEDLINE | ID: mdl-21111240

5.

Lysosomal positioning regulates Rab10 phosphorylation at LRRK2⁺ lysosomes.

Kluss, Jillian H; Beilina, Alexandra; Williamson, Chad D; Lewis, Patrick A; Cookson, Mark R; Bonet-Ponce, Luis.

Proc Natl Acad Sci U S A ; 119(43): e2205492119, 2022 10 25.

Artigo em Inglês | MEDLINE | ID: mdl-36256825

6.

Genome-Wide Analysis of Structural Variants in Parkinson Disease.

Billingsley, Kimberley J; Ding, Jinhui; Jerez, Pilar Alvarez; Illarionova, Anastasia; Levine, Kristin; Grenn, Francis P; Makarious, Mary B; Moore, Anni; Vitale, Daniel; Reed, Xylena; Hernandez, Dena; Torkamani, Ali; Ryten, Mina; Hardy, John; Chia, Ruth; Scholz, Sonja W; Traynor, Bryan J; Dalgard, Clifton L; Ehrlich, Debra J; Tanaka, Toshiko; Ferrucci, Luigi; Beach, Thomas G; Serrano, Geidy E; Quinn, John P; Bubb, Vivien J; Collins, Ryan L; Zhao, Xuefang; Walker, Mark; Pierce-Hoffman, Emma; Brand, Harrison; Talkowski, Michael E; Casey, Bradford; Cookson, Mark R; Markham, Androo; Nalls, Mike A; Mahmoud, Medhat; Sedlazeck, Fritz J; Blauwendraat, Cornelis; Gibbs, J Raphael; Singleton, Andrew B.

Ann Neurol ; 93(5): 1012-1022, 2023 05.

Artigo em Inglês | MEDLINE | ID: mdl-36695634

7.

Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia.

Mamais, Adamantios; Kluss, Jillian H; Bonet-Ponce, Luis; Landeck, Natalie; Langston, Rebekah G; Smith, Nathan; Beilina, Alexandra; Kaganovich, Alice; Ghosh, Manik C; Pellegrini, Laura; Kumaran, Ravindran; Papazoglou, Ioannis; Heaton, George R; Bandopadhyay, Rina; Maio, Nunziata; Kim, Changyoun; LaVoie, Matthew J; Gershlick, David C; Cookson, Mark R.

PLoS Biol ; 19(12): e3001480, 2021 12.

Artigo em Inglês | MEDLINE | ID: mdl-34914695

8.

THAP1 modulates oligodendrocyte maturation by regulating ECM degradation in lysosomes.

Yellajoshyula, Dhananjay; Pappas, Samuel S; Rogers, Abigail E; Choudhury, Biswa; Reed, Xylena; Ding, Jinhui; Cookson, Mark R; Shakkottai, Vikram G; Giger, Roman J; Dauer, William T.

Proc Natl Acad Sci U S A ; 118(31)2021 08 03.

Artigo em Inglês | MEDLINE | ID: mdl-34312226

9.

Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.

Soutar, Marc P M; Melandri, Daniela; O'Callaghan, Benjamin; Annuario, Emily; Monaghan, Amy E; Welsh, Natalie J; D'Sa, Karishma; Guelfi, Sebastian; Zhang, David; Pittman, Alan; Trabzuni, Daniah; Verboven, Anouk H A; Pan, Kylie S; Kia, Demis A; Bictash, Magda; Gandhi, Sonia; Houlden, Henry; Cookson, Mark R; Kasri, Nael Nadif; Wood, Nicholas W; Singleton, Andrew B; Hardy, John; Whiting, Paul J; Blauwendraat, Cornelis; Whitworth, Alexander J; Manzoni, Claudia; Ryten, Mina; Lewis, Patrick A; Plun-Favreau, Hélène.

Brain ; 145(12): 4349-4367, 2022 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-36074904

10.

DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.

Mazza, Melissa Conti; Shuck, Sarah C; Lin, Jiusheng; Moxley, Michael A; Termini, John; Cookson, Mark R; Wilson, Mark A.

J Neurochem ; 162(3): 245-261, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35713360

11.

Directing LRRK2 to membranes of the endolysosomal pathway triggers RAB phosphorylation and JIP4 recruitment.

Kluss, Jillian H; Bonet-Ponce, Luis; Lewis, Patrick A; Cookson, Mark R.

Neurobiol Dis ; 170: 105769, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35580815

12.

Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.

Lai, Dongbing; Alipanahi, Babak; Fontanillas, Pierre; Schwantes-An, Tae-Hwi; Aasly, Jan; Alcalay, Roy N; Beecham, Gary W; Berg, Daniela; Bressman, Susan; Brice, Alexis; Brockman, Kathrin; Clark, Lorraine; Cookson, Mark; Das, Sayantan; Van Deerlin, Vivianna; Follett, Jordan; Farrer, Matthew J; Trinh, Joanne; Gasser, Thomas; Goldwurm, Stefano; Gustavsson, Emil; Klein, Christine; Lang, Anthony E; Langston, J William; Latourelle, Jeanne; Lynch, Timothy; Marder, Karen; Marras, Connie; Martin, Eden R; McLean, Cory Y; Mejia-Santana, Helen; Molho, Eric; Myers, Richard H; Nuytemans, Karen; Ozelius, Laurie; Payami, Haydeh; Raymond, Deborah; Rogaeva, Ekaterina; Rogers, Michael P; Ross, Owen A; Samii, Ali; Saunders-Pullman, Rachel; Schüle, Birgitt; Schulte, Claudia; Scott, William K; Tanner, Caroline; Tolosa, Eduardo; Tomkins, James E; Vilas, Dolores; Trojanowski, John Q.

Ann Neurol ; 90(1): 76-88, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-33938021

13.

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk.

Lake, Julie; Reed, Xylena; Langston, Rebekah G; Nalls, Mike A; Gan-Or, Ziv; Cookson, Mark R; Singleton, Andrew B; Blauwendraat, Cornelis; Leonard, Hampton L.

Mov Disord ; 37(1): 95-105, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34542912

14.

Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes.

Filippini, Alice; Mutti, Veronica; Faustini, Gaia; Longhena, Francesca; Ramazzina, Ileana; Rizzi, Federica; Kaganovich, Alice; Roosen, Dorien A; Landeck, Natalie; Duffy, Megan; Tessari, Isabella; Bono, Federica; Fiorentini, Chiara; Greggio, Elisa; Bubacco, Luigi; Bellucci, Arianna; Missale, Mariacristina; Cookson, Mark R; Gennarelli, Massimo; Russo, Isabella.

Glia ; 69(3): 681-696, 2021 03.

Artigo em Inglês | MEDLINE | ID: mdl-33045109

15.

Correction to: Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Rovini, Amandine; Gurnev, Philip A; Beilina, Alexandra; Queralt-Martín, María; Rosencrans, William; Cookson, Mark R; Bezrukov, Sergey M; Rostovtseva, Tatiana K.

Cell Mol Life Sci ; 77(18): 3691-3692, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-31919572

16.

Molecular mechanism of olesoxime-mediated neuroprotection through targeting α-synuclein interaction with mitochondrial VDAC.

Rovini, Amandine; Gurnev, Philip A; Beilina, Alexandra; Queralt-Martín, María; Rosencrans, William; Cookson, Mark R; Bezrukov, Sergey M; Rostovtseva, Tatiana K.

Cell Mol Life Sci ; 77(18): 3611-3626, 2020 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-31760463

17.

Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics.

Wu, Chun-Xiang; Liao, Jingling; Park, Yangshin; Reed, Xylena; Engel, Victoria A; Hoang, Neo C; Takagi, Yuichiro; Johnson, Steven M; Wang, Mu; Federici, Mark; Nichols, R Jeremy; Sanishvili, Ruslan; Cookson, Mark R; Hoang, Quyen Q.

J Biol Chem ; 294(15): 5907-5913, 2019 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-30796162

18.

Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis.

Heaton, George R; Landeck, Natalie; Mamais, Adamantios; Nalls, Mike A; Nixon-Abell, Jonathon; Kumaran, Ravindran; Beilina, Alexandra; Pellegrini, Laura; Li, Yan; Harvey, Kirsten; Cookson, Mark R.

Neurobiol Dis ; 141: 104948, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-32434048

19.

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

Liu, Zhiyong; Bryant, Nicole; Kumaran, Ravindran; Beilina, Alexandra; Abeliovich, Asa; Cookson, Mark R; West, Andrew B.

Hum Mol Genet ; 27(2): 385-395, 2018 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-29177506

20.

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice.

Pellegrini, Laura; Hauser, David N; Li, Yan; Mamais, Adamantios; Beilina, Alexandra; Kumaran, Ravindran; Wetzel, Andrea; Nixon-Abell, Jonathon; Heaton, George; Rudenko, Iakov; Alkaslasi, Mor; Ivanina, Natalie; Melrose, Heather L; Cookson, Mark R; Harvey, Kirsten.

Hum Mol Genet ; 27(18): 3257-3271, 2018 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-29917075

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