Detalhe da pesquisa
1.
Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures.
Proc Natl Acad Sci U S A
; 117(8): 4142-4151, 2020 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047034
2.
Rational Control of Off-State Heterogeneity in a Photoswitchable Fluorescent Protein Provides Switching Contrast Enhancement.
Chemphyschem
; 23(19): e202200192, 2022 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35959919
3.
De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure.
Nature
; 539(7627): 43-47, 2016 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27680699
4.
Biochemical, structural and dynamical studies reveal strong differences in the thermal-dependent allosteric behavior of two extremophilic lactate dehydrogenases.
J Struct Biol
; 213(3): 107769, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34229075
5.
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes.
J Enzyme Inhib Med Chem
; 35(1): 498-505, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31914836
6.
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
Molecules
; 23(3)2018 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29534488
7.
An ER-peroxisome tether exerts peroxisome population control in yeast.
EMBO J
; 32(18): 2439-53, 2013 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23900285
8.
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Bioorg Med Chem
; 25(2): 633-645, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908752
9.
BRCA1 Circos: a visualisation resource for functional analysis of missense variants.
J Med Genet
; 52(4): 224-30, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25643705
10.
Raster-scanning serial protein crystallography using micro- and nano-focused synchrotron beams.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 5): 1184-96, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25945583
11.
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.
Bioorg Med Chem
; 23(15): 4442-4452, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116179
12.
Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc Natl Acad Sci U S A
; 108(52): 21022-7, 2011 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22171004
13.
Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions.
Mol Biol Evol
; 29(6): 1683-94, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22319152
14.
Xtrapol8 enables automatic elucidation of low-occupancy intermediate-states in crystallographic studies.
Commun Biol
; 5(1): 640, 2022 06 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-35768542
15.
Time-resolved serial femtosecond crystallography on fatty-acid photodecarboxylase: lessons learned.
Acta Crystallogr D Struct Biol
; 78(Pt 9): 1131-1142, 2022 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36048153
16.
An Nâ¯Hâ¯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.
Chem Sci
; 13(34): 10057-10065, 2022 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36128223
17.
De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals.
Nat Commun
; 13(1): 4376, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35902572
18.
Impact of BRCA1 BRCT domain missense substitutions on phosphopeptide recognition.
Biochemistry
; 50(21): 4579-89, 2011 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-21473589
19.
Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps.
IUCrJ
; 8(Pt 4): 633-643, 2021 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34258011
20.
Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.
IUCrJ
; 8(Pt 1): 46-59, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33520242