1.
J Org Chem
; 84(18): 12058-12070, 2019 09 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31446758
RESUMO
We report the intramolecular Tsuji-Trost reaction of Ugi adducts to give spiro-diketopiperazines in high yield and with high enantioselectivity. This approach allows the catalytic asymmetric construction of a broad range of these medicinally important heterocycles under mild conditions, in two steps from cheap, commercially available starting materials.