Detalhe da pesquisa
1.
Preclinical profile of BI 224436, a novel HIV-1 non-catalytic-site integrase inhibitor.
Antimicrob Agents Chemother
; 58(6): 3233-44, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24663024
2.
Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.
J Med Chem
; 67(1): 774-781, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38156904
3.
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein.
J Virol
; 86(12): 6643-55, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22496222
4.
N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.
Bioorg Med Chem Lett
; 23(16): 4663-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23809849
5.
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Bioorg Med Chem Lett
; 23(14): 4132-40, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23768906
6.
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2585-9, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23545108
7.
Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Bioorg Med Chem Lett
; 23(24): 6879-85, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24176401
8.
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
Bioorg Med Chem Lett
; 21(1): 398-404, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21087861
9.
Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
J Am Chem Soc
; 132(43): 15204-12, 2010 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20942454
10.
N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Bioorg Med Chem Lett
; 20(3): 857-61, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20074949
11.
Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.
Bioorg Med Chem Lett
; 19(4): 1199-205, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19138518
12.
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.
ACS Med Chem Lett
; 7(8): 797-801, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27563405
13.
Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
J Med Chem
; 57(5): 1845-54, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24159919
14.
Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.
J Med Chem
; 57(5): 1944-51, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24024973
15.
Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.
J Med Chem
; 57(5): 2074-90, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24467709
16.
Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
J Med Chem
; 57(5): 1932-43, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773186
17.
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
ACS Med Chem Lett
; 5(6): 711-6, 2014 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24944749
18.
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
ACS Med Chem Lett
; 5(4): 422-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900852
19.
Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.
J Med Chem
; 56(17): 7073-83, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23919803
20.
Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.
J Med Chem
; 56(12): 5142-50, 2013 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-23730910